Rams vs 49ers Prediction: Odds, Picks & Betting Preview Week 18 – January 7, 2024

httpscdn.dataskrive.comapiasset4I0C9lk Betsperts Media & Technology

bet365 Sportsbook Promo
$1,000 First Bet Safety Net or Bet $5, Get $150
FanDuel Promo Code
Bet $5, Get $200 in bonus bets if your bet WINS!
Caesars Sportsbook Promo Code
Claim a First Bet on Caesars up to $1,000!
DraftKings Promo Code
Up to $300 in bonus bets!
BetMGM Sportsbook Promo
$1,500 First Bet Offer

As they look to continue a three-game winning streak, the Los Angeles Rams (9-7) visit the San Francisco 49ers (12-4) at Levi’s Stadium on Sunday, January 7, 2024.

49ers vs. Rams Odds

Point Spread

The spread for this matchup is set at 5.5 points, with oddsmakers listing the 49ers as the favorites.


As for the moneyline, the 49ers have -238 odds to pick up the win, while the Rams are listed at +195 to claim victory.


Finally, the over/under for the game is set at 40 points.

Game Info

How to Watch 49ers vs. Rams Live?

  • Game Day: Sunday, January 7, 2024
  • Game Time: 4:25 PM ET
  • TV Channel: FOX
  • Location: Santa Clara, California
  • Stadium: Levi’s Stadium

Betting Preview


Offensively, the 49ers have been a top-five unit, ranking second-best in the NFL by totaling 404.6 yards per game. They rank seventh on defense (306.8 yards allowed per game). The 49ers have been shining on both offense and defense, ranking second-best in scoring offense (29.4 points per game) and second-best in scoring defense (17.3 points allowed per game).

The 49ers have the 15th-ranked defense this season in terms of passing yards (218.3 allowed per game), and they’ve been more effective offensively, ranking second-best with 263.1 passing yards per game. The 49ers have been finding success on both offense and defense in the running game, ranking third-best in rushing offense (141.5 rushing yards per game) and third-best in rushing defense (88.5 rushing yards allowed per game).

The 49ers rank 22nd in third-down defense this year (39.5% third-down conversion rate allowed), but they’ve been shining on offense, ranking fourth-best in the NFL with a 47.3% third-down conversion rate. On the offensive side of the ball, the 49ers have been a top-five unit in terms of yards per play, ranking best in the NFL by compiling 6.7 yards per play. They rank seventh on defense (5 yards per play allowed). With 27 forced turnovers (third in NFL) against 17 turnovers committed (fifth in NFL), the 49ers’ +10 turnover margin is the third-best in the league.


From an offensive angle, the Rams are putting up 365.6 total yards per game (seventh-ranked). They rank 19th in the NFL on defense (340.3 total yards allowed per game). In terms of points scored the Rams rank eighth in the NFL (23.9 points per game), and they are 19th on the other side of the ball (22.3 points allowed per contest).

From an offensive standpoint, the Rams are generating 244.6 passing yards per contest (eighth-ranked). They rank 25th in the NFL defensively (234.6 passing yards surrendered per game). The Rams rank 11th in the NFL with 121 rushing yards per contest on offense, and they rank 12th with 105.7 rushing yards given up per game on the defensive side of the ball.

The Rams rank 12th in the NFL with a 40.8% third-down conversion percentage on offense, and 15th with a 38.1% third-down percentage allowed on defense. The Rams’ offense has been excelling in terms of yards per play, accumulating 5.7 (fifth-best) this season. Defensively, they rank 19th by allowing 5.3 yards per play. After forcing 14 turnovers (30th in NFL) and turning the ball over 17 times (fifth in NFL) this season, the Rams sport the 21st-ranked turnover margin of -3.

49ers vs. Rams Injury Report


Player Pos. Injury Status
Christian McCaffrey RB Calf Out
Kyle Juszczyk FB Illness Probable
Brock Purdy QB Coach’s decision Out
Ambry Thomas CB Hand Out
Jauan Jennings WR Concussion Out
Ross Dwelley TE Ankle Out


Player Pos. Injury Status
Kyren Williams RB Nir (coaching) Out
Cooper Kupp WR Nir (coaching) Out
Matthew Stafford QB Nir (coaching) Out
Aaron Donald DT Nir (coaching) Out
Tyler Higbee TE Shoulder Out
Shaun Jolly DB Undisclosed Out
Ernest Jones LB Nir (coaching) Out
Duke Shelley DB Hamstring Questionable

49ers vs. Rams Betting Analysis

49ers Betting Insights

The 49ers have registered a 9-7-0 record against the spread this season. In games they have played as 5.5-point favorites or more, the 49ers have an ATS record of 5-6.

This season, 49ers games have hit the over eight times.

Rams Betting Insights

The Rams have put together a 9-6-1 record against the spread this year. The Rams are 2-1 ATS when playing as at least 5.5-point underdogs.

Rams games have finished with a final combined score above the over/under eight times this season. The Rams have won one of the seven games they’ve played as underdogs this season.

This season, the Rams have been at least a +195 underdog on the moneyline three times, losing each of those contests.

49ers vs. Rams Against The Spread & Betting Records


Overall Home Away
Point Total AVG 44.3 44.4 44.1
Implied Team Total AVG 26.4 27.3 25.8
ATS Record 9-7-0 3-4-0 6-3-0
Over/Under Record 8-7-1 4-3-0 4-4-1
Moneyline Favorite Record 12-4 5-2 7-2
Moneyline Underdog Record 0-0 0-0 0-0


Overall Home Away
Point Total AVG 44.6 45.8 43.4
Implied Team Total AVG 24.8 25.5 24.1
ATS Record 9-6-1 5-3-0 4-3-1
Over/Under Record 8-8-0 3-5-0 5-3-0
Moneyline Favorite Record 8-1 5-1 3-0
Moneyline Underdog Record 1-6 0-2 1-4

Players to Watch


  • Deebo Samuel’s 871 receiving yards this season have come from 58 receptions on 87 targets. He’s averaging 4.1 catches and 62.2 yards per game, with seven receiving touchdowns.
  • Brandon Aiyuk’s 1,317 receiving yards this season (sixth in the NFL) have come from 101 targets and 72 receptions. He’s averaging 87.8 receiving yards and 4.8 catches per game, with seven receiving touchdowns.
  • In the passing attack, George Kittle, has racked up 1,020 receiving yards and six touchdowns after grabbing 65 balls on 90 targets. Per game, he’s averaging 63.8 yards and 4.1 receptions in 16 games.
  • In the running game, Jordan Mason averages 5 yards per attempt and 10.6 yards per game for 170 total rushing yards. He has scored three rushing touchdowns this season.
  • Over on the defensive side, Fred Warner has four interceptions (seventh in the NFL) to go with 133 tackles, six TFL, three sacks, and 11 passes defended in 2023.
  • Nick Bosa has 52 tackles, 16 TFL, and 10 sacks this season.
  • Dre Greenlaw has recorded 120 tackles, five TFL, and 1.5 sacks this year.
  • So far this season, Charvarius Ward has 68 tackles, two TFL, and five interceptions.


  • Matthew Stafford is averaging 7.6 passing yards per attempt (fifth in the NFL) and 264.3 yards per game this year, completing 62.6% of his passes on the way to 3,965 total yards (seventh in the NFL), 24 touchdowns (10th in the NFL) and 11 interceptions through 15 games.
  • Kyren Williams has scored 12 rushing touchdowns, while totaling 1,144 rushing yards (5 per carry and 95.3 per game).
  • Williams has also picked up 206 receiving yards (17.2 per game) on 32 catches (2.7 per game). He’s been targeted 48 times and has caught three touchdown passes.
  • In 16 games played this season, Puka Nacua has 101 catches (6.3 receptions per game on 9.6 targets per game) for 1,445 yards (fourth in the NFL) and five receiving touchdowns.
  • Cooper Kupp has 59 catches for 737 yards and five receiving touchdowns. He averages 4.9 yards per game in 12 games and has been targeted 95 times.
  • Ernest Jones has 145 tackles, 14 TFL, 4.5 sacks, and six passes defended in 2023.
  • Jordan Fuller has registered one TFL, 92 tackles, and three interceptions over 16 games.
  • Aaron Donald has eight sacks (second on the Rams) as well as 16 TFL and 53 tackles in the 2023 season.
  • Byron Young’s stats include 60 tackles, seven TFL, and seven sacks in 16 games

49ers vs. Rams Predictions and Pick

Our pick to win this matchup is the 49ers, and we expect that 49ers will cover the spread (49ers -5.5). Finally, we see the scoring in this one going over the posted total of 40 points.

How to Bet on 49ers vs. Rams

You can bet this 49ers vs. Rams pick at every legal online sportsbook

You can check our live NFL lines for the latest NFL odds, including money lines, spreads, and over/under totals.

Tip: If you want to check out how much you could win on a $10 bet if you parlayed today’s 49ers vs. Rams picks, don’t forget to check out our free parlay calculator.

What is a parlay? Or even how to bet on football? Check out our complete guide to the best NFL betting sites.

bet365 Sportsbook Promo
$1,000 First Bet Safety Net or Bet $5, Get $150
FanDuel Promo Code
Bet $5, Get $200 in bonus bets if your bet WINS!
Caesars Sportsbook Promo Code
Claim a First Bet on Caesars up to $1,000!
DraftKings Promo Code
Up to $300 in bonus bets!
BetMGM Sportsbook Promo
$1,500 First Bet Offer


Matt Rooney

Matt comes from Chicago and has lived in the area his whole life. Graduated from and played football at Illinois Wesleyan University in Bloomington, IL while also serving as the director of student sports broadcasting. He writes for Betsperts as well as appears on several shows across the network.

Deals of the Day

See All