Purdue vs. Indiana Prediction: Picks & Start Time – November 26, 2022

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Big Ten opponents will meet when the Purdue Boilermakers (7-4) meet the Indiana Hoosiers (4-7).

Purdue vs. Indiana Odds

Point Spread

The spread for this matchup is set at 10.5 points, with bookmakers listing Purdue as the favorites.


As for the moneyline, Purdue has -405 odds to pick up the win, while Indiana is listed at +305 to claim victory.


Finally, the over/under for the game is set at 53.5 points.

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Game Info

How to Watch Purdue vs. Indiana Live?

  • Game Day: Saturday, November 26, 2022
  • Game Time: 3:30 PM ET
  • TV Channel: BTN
  • Location: Bloomington, Indiana
  • Stadium: Memorial Stadium (Bloomington, IN)

Betting Preview


On offense, Purdue ranks 53rd in the FBS with 408.2 yards per game. Meanwhile, its defense ranks 35th in total defense (340.3 yards allowed per contest). Purdue is putting up 28.5 points per game offensively this year (68th in the FBS), and is allowing 23.7 points per game (43rd) on defense. Purdue ranks 61st in pass defense this year (219.4 passing yards allowed per game), but has been playing really well on the offensive side of the ball, ranking 23rd-best in the FBS with 279.0 passing yards per game. Purdue is putting up 129.2 rushing yards per game offensively this season (97th in the FBS), and is surrendering 120.9 rushing yards per game (27th) on the defensive side of the ball. On the defensive side of the ball, Purdue has been a top-25 unit in terms of third-down efficiency, ranking 17th-best by surrendering a 31.5% third-down percentage. The team’s offense ranks 61st (39.6% third-down percentage). With 17 forced turnovers (47th in the FBS) against 18 turnovers committed (90th in the FBS), Purdue (-1) has the 100th-ranked turnover margin in college football.

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Indiana has plenty of room to improve, as it ranks 17th-worst in total yards per game (319.8) and ninth-worst in total yards surrendered per game (454.8). Indiana’s defense has been a bottom-25 unit in scoring defense this season, conceding 34.3 points per game, which ranks 12th-worst in the FBS. On offense, it ranks 93rd with 23.9 points per contest. Indiana has been struggling to stop the pass, ranking 17th-worst with 272.7 passing yards surrendered per game. It has been more productive on offense, generating 218.5 passing yards per contest (83rd-ranked). Indiana’s running game has not been getting things done, ranking 13th-worst in the FBS with 101.4 rushing yards per game. It has been more effective on the defensive side of the ball, allowing 182.1 rushing yards per contest (102nd-ranked). In terms of third-down efficiency, this season has been rough for Indiana on both offense and defense, as it is putting up a 33.5% third-down conversion percentage (20th-worst) and allowing a 43.2% conversion rate (22nd-worst). At -5, Indiana owns the 100th-ranked turnover margin in the FBS, with 12 forced turnovers (105th in the FBS) and 17 turnovers committed (74th in the FBS).

Purdue vs. Indiana Betting Analysis

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Purdue Betting Insights

Purdue is 4-7-0 against the spread this season. In games it has played as 10.5-point favorites or more, Purdue has an ATS record of 1-3. This season, seven Purdue games have gone over the point total. The Boilermakers are 3-1 in games they were favored on the moneyline (winning 75% of those games). The Boilermakers have played in three games as a moneyline favorite with odds of -405 or shorter and won every time.

Hoosiers Betting Insights

Indiana have compiled a 4-7-0 record against the spread this year. In games as an underdog by 10.5 points or more so far this season, the Hoosiers have gone 3-3 against the spread. Indiana’s games have finished with a final combined score above the over/under seven times this year. The Hoosiers have entered the game as underdogs seven times this season and won once. The Hoosiers are 1-4 this season when entering a game as the underdog by +305 or more on the moneyline.

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Purdue vs. Indiana Against The Spread & Betting Records


Overall Home Away
Point Total AVG 51.9 50.6 53.4
Implied Total AVG 31.2 33.0 29.0
ATS Record 4-7-0 1-5-0 3-2-0
Over/Under Record 7-4-0 3-3-0 4-1-0
Moneyline Favorite Record 3-1 3-1 0-0
Moneyline Underdog Record 3-3 0-1 3-2


Overall Home Away
Point Total AVG 54.9 54.7 55.1
Implied Total AVG 34.8 34.2 35.6
ATS Record 4-7-0 3-3-0 1-4-0
Over/Under Record 7-4-0 4-2-0 3-2-0
Moneyline Favorite Record 3-0 3-0 0-0
Moneyline Underdog Record 1-6 0-3 1-3

Players to Watch


  • The Boilermakers’ defense has been helped by the play of Jalen Graham, who has suited up for 11 games and amassed 37 tackles, 3.0 TFL, one sack, and one interception.
  • Sanoussi Kane has played 11 games, amassing 36 tackles, 1.0 TFL, and one sack for the Boilermakers.
  • Jack Sullivan has helped spur the Boilermakers’ defense with 20 tackles, 4.0 TFL, and five sacks in 11 games.
  • An important piece of the Boilermakers’ defense, Cam Allen has three interceptions to go with 26 tackles and three passes defended in 11 games.


  • Aaron Casey has been causing chaos on defense, registering 64 tackles, 3.0 TFL, and 1.5 sacks for the Hoosiers.
  • In 11 games for the Hoosiers, Bryant Fitzgerald has collected one interception to go with 50 tackles, 1.0 TFL, 0.5 sacks, and one pass defended.
  • Dasan McCullough has totaled 4.0 sacks to go with 4.0 TFL and 32 tackles in 11 games for the Hoosiers.
  • With 49 tackles, 5.0 TFL, and one sack in 11 games, Bradley Jennings Jr. has been wreaking havoc on defense for the Hoosiers.

Purdue vs. Indiana Predictions and Pick

Purdue vs. Indiana betting card

    Pick ATS:

    Hoosiers (+10.5)

    Pick OU:

    Over (53.5)

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How to Bet on Purdue vs. Indiana

You can bet on Purdue vs. Indiana at every legal online sportsbook. For more college football odds, including moneylines, spreads, over/under totals as well as college football prop odds, check out the latest college football lines as well as our guide to the best college football betting sites.

And if you wanted to check out how much you could win on a $10 bet if you parlayed today’s Purdue vs. Indiana picks, don’t forget to check out our free parlay calculator.

Not sure what a parlay is? Or even how to bet on college football? Check out our complete guide to sports betting.

Our pick to win this matchup is Purdue, and we project that Indiana will cover the spread (Purdue -10.5). Finally, we see the scoring in this one going over the posted total of 53.5 points.


Matt Rooney

Matt comes from Chicago and has lived in the area his whole life. Graduated from and played football at Illinois Wesleyan University in Bloomington, IL while also serving as the director of student sports broadcasting. He writes for Betsperts as well as appears on several shows across the network.

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