Louisville vs. South Florida Prediction: Picks & Start Time – September 2022

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The Louisville Cardinals (1-2) and South Florida Bulls (1-2) will battle at Cardinal Stadium in Louisville, Kentucky.

Louisville vs. South Florida Odds

Point Spread

The spread for this matchup is set at 14.5 points, with sportsbooks listing Louisville as the favorites.


As for the moneyline, Louisville has -666 odds to pick up the win, while South Florida is listed at +435 to claim victory.


Finally, the over/under for the game is set at 63 points.


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Game Info

How to Watch Louisville vs. South Florida Live?

  • Game Day: Saturday, September 24, 2022
  • Game Time: 12:00 PM ET
  • TV Channel: RSN
  • Location: Louisville, Kentucky
  • Stadium: Cardinal Stadium

Betting Preview


Louisville is putting up 416.7 yards per game on offense this year (68th in the FBS), and are allowing 414.3 yards per game (100th) on defense. Louisville ranks 19th-worst in scoring offense (19.3 points per game), but has been slightly better on defense, ranking 77th with 26.7 points allowed per contest. Louisville is compiling 211.7 passing yards per game on offense (98th in the FBS), and ranks 66th on defense with 213.0 passing yards allowed per game. Despite sporting a bottom-25 run defense that ranks 15th-worst in the FBS (201.3 rushing yards allowed per game), Louisville has put up better results offensively, ranking 37th in the FBS by totaling 205.0 rushing yards per game. Louisville is averaging a 35.9% third-down conversion rate on offense, which ranks them 91st in the FBS. On the other side of the ball, the defense ranks 79th, surrendering a 39.0% third-down conversion rate. With three forced turnovers (93rd in the FBS) against seven turnovers committed (103rd in the FBS), Louisville (-4) has the 100th-ranked turnover margin in college football.

South Florida

South Florida’s defense has been bottom-25 in total defense this season, allowing 440.7 total yards per game, which ranks 19th-worst. On offense, it ranks 89th with 373.0 total yards per contest. South Florida ranks 79th in points per game (30.3), but it has been less productive on the other side of the ball, ranking 25th-worst in the FBS with 33.7 points surrendered per contest. South Florida’s passing game has not been getting things done, ranking 20th-worst in the FBS with 169.0 passing yards per game. It has been more productive on defense, allowing 207.7 passing yards per contest (61st-ranked). South Florida’s defense has been bottom-25 in run defense this season, surrendering 233.0 rushing yards per game, which ranks ninth-worst in the FBS. Offensively, it ranks 41st with 204.0 rushing yards per contest. South Florida’s defense has been bottom-25 on third down this season, allowing a 50.0% third-down conversion rate, which ranks 13th-worst in the FBS. On the offensive side of the ball, it ranks 87th with a 50.0% third-down rate. After forcing six turnovers (25th in the FBS) and turning the ball over five times (72nd in the FBS) this season, South Florida sports the 45th-ranked turnover margin of +1.

Louisville vs. South Florida Betting Analysis

Louisville Betting Insights

Louisville has covered the spread one time this season (1-2-0). This season, Louisville games have hit the over once. The Cardinals have been listed as the moneyline favorite only one other time so far this season, a game they lost. The Cardinals have yet to play as a moneyline favorite of -666 or shorter.

Bulls Betting Insights

South Florida has gone 1-2-0 against the spread this season. South Florida has a perfect 1-0 ATS record when playing as at least 14.5-point underdogs. This season, each South Florida game has hit the over. The Bulls have lost both games they’ve played as underdogs this season. The Bulls have a record of 0-0 when they’re set as an underdog of +435 or more by oddsmakers this season.


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Louisville vs. South Florida Against The Spread & Betting Records


Overall Home Away
Point Total AVG 58.3 57.0 59.0
Implied Total AVG 31.7 30.0 32.5
ATS Record 1-2-0 0-1-0 1-1-0
Over/Under Record 1-2-0 1-0-0 0-2-0
Moneyline Favorite Record 0-1 0-0 0-1
Moneyline Underdog Record 1-1 0-1 1-0


Overall Home Away
Point Total AVG 58.8 59.0 58.5
Implied Total AVG 41.7 42.0 41.0
ATS Record 1-2-0 0-2-0 1-0-0
Over/Under Record 3-0-0 2-0-0 1-0-0
Moneyline Favorite Record 0-0 0-0 0-0
Moneyline Underdog Record 0-2 0-1 0-1

Players to Watch


  • The Cardinals’ defense has been helped by the contributions of YaYa Diaby, who has played three games and totaled 13 tackles, 3.0 TFL, and three sacks.
  • Kenderick Duncan Jr. has helped carry the Cardinals’ defense with 24 tackles in three games.
  • The Cardinals’ defense has been helped by Benjamin Perry, who has suited up for three games and recorded 19 tackles and 1.0 TFL.
  • MoMo Sanogo has been a key part of the Cardinals’ defensive unit in 2022, with 19 tackles, 1.0 TFL, and 0.5 sacks in three games.


  • Jatorian Hansford has been causing chaos on defense, delivering seven tackles, 2.0 TFL, and one sack for the Bulls.
  • In three games for the Bulls, Mekhi LaPointe has amassed one interception to go with 10 tackles, 1.0 TFL, one sack, and one pass defended.
  • The Bulls’ Dwayne Boyles has delivered one interception to go with nine tackles, 2.0 TFL, and one pass defended in three games.
  • On defense, Jayden Curry has chipped in with five tackles and one interception in three games.

Louisville vs. South Florida Predictions and Pick

Louisville vs. South Florida betting card

    Pick ATS:

    Cardinals (-14.5)

    Pick OU:

    Under (63)


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How to Bet on Louisville vs. South Florida

You can bet on Louisville vs. South Florida at every legal online sportsbook. For more college football odds, including moneylines, spreads, over/under totals as well as college football prop odds, check out the latest college football lines as well as our guide to the best college football betting sites.

And if you wanted to check out how much you could win on a $10 bet if you parlayed today’s Louisville vs. South Florida picks, don’t forget to check out our free parlay calculator.

Not sure what a parlay is? Or even how to bet on college football? Check out our complete guide to sports betting.

Our pick to win this game is Louisville, and we predict that Louisville will cover the spread (Louisville -14.5). Finally, we see the scoring in this one going under the posted total of 63 points.


Dan Weiner

Hailing from Atlanta and attending college at the University of Texas, Dan is passionate about sports, particularly college football and soccer. He's a diehard Atlanta pro sports and Texas Longhorns fan. He likes every sport and will watch anything and everything the weirder the better. He joined Betsperts after an 11 year career in television production at ESPN.

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