Titans vs Bills Prediction: Odds, Picks & Betting Preview Week 2 – September 19, 2022

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Highmark Stadium is where the Tennessee Titans (0-1) will do battle with the Buffalo Bills (1-0) on Monday, September 19, 2022.

Bills vs. Titans Odds

Point Spread

The spread for this matchup is set at 10 points, with sportsbooks listing the Bills as the favorites.


As for the moneyline, the Bills have -450 odds to pick up the win, while the Titans are listed at +360 to claim victory.


Finally, the over/under for the game is set at 48 points.

Game Info

How to Watch Bills vs. Titans Live?

  • Game Day: Monday, September 19, 2022
  • Game Time: 7:15 PM ET
  • TV Channel: ESPN
  • Location: Orchard Park, New York
  • Stadium: Highmark Stadium

Betting Preview


  • The Bills scored 28.4 points per game last year, 7.6 more than the Titans gave up.
  • Buffalo was 9-3 against the spread and 11-2 overall in games when it scored more than 20.8 points last year.
  • The Bills had a 52.1-yard advantage in yards gained versus yards allowed last season compared to the Titans (381.9 to 329.8). The Bills averaged 5.7 yards per play, while the Titans gave up 5.4 per play.
  • Buffalo was 7-4 against the spread and 9-3 overall when the team picked up more than 329.8 yards last year.
  • The Titans gave up 84.6 rushing yards per game last year. That was 45.3 fewer than the Bills gained per game (129.9).
  • Buffalo had a 9-5 ATS record and an 11-4 overall record when the team rushed for more than 84.6 yards last year.


  • The Titans averaged 7.6 more points scored last year (24.6) than the Bills gave up (17.0).
  • Tennessee was 10-3 against the spread and 12-1 overall in games when it scored more than 17.0 points last season.
  • The Bills surrendered 272.8 yards per game last year, 69.7 fewer yards than the Titans generated (342.5). The Titans gained 5.1 yards per play, while the Bills allowed 4.6.
  • When Tennessee amassed over 272.8 yards last year, the team was 8-5 against the spread and 9-4 overall.
  • The Bills’ defense gave up an average of 109.8 yards to opposing running games last season. That is 31.6 fewer yards than the Titans averaged running the football (141.4).
  • Tennessee had a 5-4 ATS record and a 6-3 overall record when the team rushed for more than 109.8 yards last season.

Bills vs. Titans Injury Report


Bills: CB Dane Jackson: Questionable (Knee), DT Ed Oliver: Out (Ankle), DT Tim Settle: Doubtful (Calf), WR Gabriel Davis: Questionable (Ankle)


Titans: WR Kyle Philips: Questionable (Shoulder), LB Monty Rice: Out (Achilles), TE Tommy Hudson: Out (Undisclosed), DE Da’Shawn Hand: Out (Quad), FB A.J. Moore: Out (Ankle), CB Kristian Fulton: Out (Hamstring), FB Jamarco Jones: Out (Tricep), RB Dontrell Hilliard: Out (Hamstring)

Bills vs. Titans Betting Analysis

Bills Betting Insights

  • Against the spread, the Bills were 9-7-1 last season.
  • As 10-point favorites or more, the Bills went 5-1-1 against the spread last season.
  • Buffalo was the moneyline favorite 14 total times last season. They finished 9-5 in those games.
  • Buffalo went 6-1 when playing as a moneyline favorite with odds of -450 or shorter (85.7%).
  • Last season, eight of the Bills’ 17 games hit the over.

Titans Betting Insights

  • The Titans covered the spread 10 times in 17 games last year.
  • Tennessee was an underdog eight times last season and won six of those games.
  • Tennessee was not a bigger underdog last season than the +360 moneyline set for this game.
  • Last season, eight of the Titans’ 17 games hit the over.

Bills vs. Titans Against The Spread & Betting Records


Overall Home Away
Point Total AVG 47.5 45.6 49.6
Implied Total AVG 28.2 28.4 28.0
ATS Record 9-7-1 4-4-1 5-3-0
Over/Under Record 8-9-0 3-6-0 5-3-0
Moneyline Favorite Record 9-5 6-3 3-2
Moneyline Underdog Record 2-1 0-0 2-1


Overall Home Away
Point Total AVG 47.8 47.9 47.6
Implied Total AVG 26.8 26.7 26.9
ATS Record 10-7-0 6-3-0 4-4-0
Over/Under Record 8-9-0 2-7-0 6-2-0
Moneyline Favorite Record 6-3 4-2 2-1
Moneyline Underdog Record 6-2 3-0 3-2

Players to Watch


  • Josh Allen threw for 4,407 yards last year (to rank eighth in the NFL), with 36 touchdowns (seventh in the NFL) and 15 interceptions. He completed 63.3% of his attempts while averaging 259.2 yards per game and 6.8 per attempt.
  • Allen also rushed for six touchdowns and 763 yards.
  • Stefon Diggs put together a 2021 campaign that included 103 catches (ninth in the NFL) for 1,225 yards (eighth in the NFL) and 10 receiving touchdowns (sixth in the NFL) over 17 games played. He was on the receiving end of 164 targets and averaged 6.1 receptions per game.
  • Devin Singletary averaged 51.2 rushing yards per game last season (870 total yards), while scoring seven rushing touchdowns.
  • In addition to his ground game, Singletary pulled down 40 passes (on 50 targets) for 228 yards with one receiving touchdown. He averaged 13.4 yards per game.
  • Dawson Knox had 49 catches for 587 yards and nine receiving touchdowns (ninth in the NFL). He averaged 3.3 yards per game over 15 games and was targeted 71 times.
  • In 2021, Jordan Poyer had 93 tackles, 8.0 TFL, 3.0 sacks, and five interceptions over 16 games.
  • Micah Hyde had 74 tackles, 4.0 TFL, 1.0 sack, and five interceptions.
  • Matt Milano had 3.0 sacks in addition to his 14.0 TFL and 86 tackles.
  • Tremaine Edmunds’ stats included one interception as well as 108 tackles, 7.0 TFL, and four passes defended in 15 games


  • In addition to his 3,734 passing yards and 67.2% completion percentage last season, Ryan Tannehill tallied 21 touchdowns against 14 interceptions.
  • Tannehill also helped the offense with his legs, running for 270 yards (4.9 YPC) and seven touchdowns.
  • As a runner, Derrick Henry compiled 937 rushing yards with 10 touchdowns.
  • As a pass-catcher, Henry compiled 18 receptions (on 20 targets) for 154 yards and zero touchdowns.
  • In nine games with the Rams last season, Robert Woods turned 69 targets into 45 catches, 556 yards and four touchdowns.
  • As an important contributor in the passing game, Nick Westbrook-Ikhine tallied 476 receiving yards and four touchdowns on 38 catches.
  • On defense Kevin Byard, who played in 17 games, posted 88 tackles, 1.0 TFL, 1.0 sack, and five interceptions.
  • With 54 tackles, 12.0 TFL, 8.5 sacks, and six passes defended in 17 games, Jeffery Simmons was a significant player on defense last season.
  • Denico Autry was on the field for 17 games and posted 31 tackles, 10.0 TFL, 9.0 sacks, and six passes defended.
  • With 7.0 TFL and 93 tackles, Zach Cunningham made a big difference on D.

Bills vs. Titans Predictions and Pick

Our prediction to win this matchup is the Bills, and we project that Titans will cover the spread (Bills -10). Finally, we see the scoring in this one going under the posted total of 48 points.

How to Bet on Bills vs. Titans

You can bet on Bills vs. Titans at every legal online sportsbook. For more NFL odds, including moneylines, spreads, over/under totals as well as NFL prop odds, check out the latest NFL lines as well as our guide to the best NFL betting sites.

And if you wanted to check out how much you could win on a $10 bet if you parlayed today’s Bills vs. Titans picks, don’t forget to check out our free parlay calculator.

Not sure what a parlay is? Or even how to bet on football? Check out our complete guide to sports betting.


Luis Escalante

Luis has been a regular contributor to 4for4 since 2014 and is currently the Director of Strategy at Betsperts Group. Luis comes from an analytics background, leveraging his data skills with multiple years of experience in NFL, fantasy football, daily fantasy sports, and betting.

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