49ers vs. Commanders Prediction: Week 16 Odds, Picks & Moneyline – December 24, 2022

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The red-hot San Francisco 49ers (10-4) carry a seven-game winning streak into a home game against the Washington Commanders (7-6-1) on Saturday, December 24, 2022 at Levi’s Stadium.

49ers vs. Commanders Odds

Point Spread

The spread for this matchup is set at 7 points, with bookmakers listing the 49ers as the favorites.


As for the moneyline, the 49ers have -320 odds to pick up the win, while the Commanders are listed at +265 to claim victory.


Finally, the over/under for the game is set at 38 points.

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Game Info

How to Watch 49ers vs. Commanders Live?

  • Game Day: Saturday, December 24, 2022
  • Game Time: 4:05 PM ET
  • TV Channel: CBS
  • Location: Santa Clara, California
  • Stadium: Levi’s Stadium

Betting Preview


The 49ers rank seventh in total offense this season (362.9 yards per game), but they’ve been thriving on the other side of the ball, ranking best in the NFL with 286.1 yards allowed per game. The 49ers rank 10th in points scored this season (24.1 points per game), but they’ve been thriving on defense, ranking best in the NFL with 15.0 points allowed per game.

Offensively, the 49ers rank 14th in the NFL with 229.4 passing yards per game. Meanwhile, they rank 13th in passing yards allowed per contest (211.4). Defensively, the 49ers have been a top-five unit in terms of rushing yards, ranking best by giving up only 74.7 per game. They rank ninth on offense (133.4 rushing yards per game).

The 49ers rank sixth in third-down efficiency (45.3%) on offense and 11th in third-down conversion rate allowed (37.8%) on defense this year. This season, the 49ers are gaining 5.8 yards per play on offense (sixth in the league), while sporting the second-best yards per play on defense in the NFL (4.8). The 49ers have forced 22 total turnovers (fourth in NFL) this season and have turned it over 15 times (sixth in NFL) for a turnover margin of +7, the third-best in the league.

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The Commanders’ defense has been paving the way for the team, as they rank fourth-best in the NFL with 308.9 total yards ceded per game. In terms of offense, they are posting 335.5 total yards per game, which ranks 20th. In terms of points scored the Commanders rank 25th in the NFL (18.9 points per game), and they are ninth defensively (19.7 points allowed per game).

From an offensive perspective, the Commanders are posting 208.6 passing yards per contest (21st-ranked). They rank eighth in the NFL on the other side of the ball (197.2 passing yards allowed per game). From an offensive angle, the Commanders are putting up 126.9 rushing yards per game (11th-ranked). They rank 12th in the NFL on the other side of the ball (111.7 rushing yards surrendered per game).

On offense, the Commanders are a bottom-five unit on third down, posting a 34.2% third-down conversion rate (fifth-worst). Fortunately, they are excelling on defense, surrendering a 32.4% third-down rate (fourth-best). The Commanders are putting up 5.0 yards per play on offense this season (25th-ranked). Meanwhile, they are allowing 5.2 yards per play (10th-ranked) on defense. After forcing 15 turnovers (22nd in NFL) and turning the ball over 17 times (13th in NFL) this season, the Commanders own the 19th-ranked turnover margin of -2.

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49ers vs. Commanders Injury Report


Player Pos. Injury Status
Christian McCaffrey RB Knee Questionable
Brock Purdy QB Oblique Questionable
Ambry Thomas CB Ankle Questionable
Charvarius Ward CB Concussion Questionable
Tarvarius Moore DB Knee Questionable
Javon Kinlaw DT Knee Questionable


Player Pos. Injury Status
Antonio Gibson RB Foot Questionable
Benjamin St-Juste CB Ankle Questionable
Saahdiq Charles OT Concussion Questionable
Andrew Norwell OG Shoulder Questionable
Curtis Hodges TE Thigh Questionable
Chase Young DE Acl Questionable

49ers vs. Commanders Betting Analysis

49ers Betting Insights

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The 49ers have put together a 9-5-0 record against the spread this season. In games they have played as 7-point favorites or more, the 49ers have an ATS record of 3-1.

49ers games have finished with a final combined score above the over/under six times this season. The 49ers were favored on the moneyline 14 total times last season. They went 8-6 in those games.

The 49ers won all three games they played as a moneyline favorite with odds of -320 or shorter.

Commanders Betting Insights

The Commanders are 8-6-0 against the spread this season. The Commanders are a perfect 1-0 ATS when playing as at least 7-point underdogs.

Games involving Commanders have hit the over four times this year. The Commanders have won three of the six games they’ve played as underdogs this season.

The Commanders have played as an underdog of +265 or more once this season and won that game.

49ers vs. Commanders Against The Spread & Betting Records


Overall Home Away
Point Total AVG 42.9 43.4 42.4
Implied Total AVG 23.6 24.1 23.1
ATS Record 9-5-0 5-2-0 4-3-0
Over/Under Record 6-8-0 3-4-0 3-4-0
Moneyline Favorite Record 9-3 6-0 3-3
Moneyline Underdog Record 1-1 0-1 1-0


Overall Home Away
Point Total AVG 42.3 42.8 41.7
Implied Total AVG 22.9 23.1 22.7
ATS Record 8-6-0 4-3-0 4-3-0
Over/Under Record 4-9-1 2-5-0 2-4-1
Moneyline Favorite Record 4-2-1 2-1 2-1-1
Moneyline Underdog Record 3-3 1-2 2-1

Players to Watch


  • Brandon Aiyuk has brought down 60 passes on 89 targets for 774 total yards and seven touchdowns. He is averaging 4.3 catches and 55.3 yards per game over 14 games played.
  • George Kittle has 46 receptions for 593 yards and six TDs. Through 12 games, he is averaging 3.8 catches and 49.4 yards per game.
  • In the passing attack, Jauan Jennings, has racked up 339 receiving yards and one touchdown after hauling in 30 balls on 48 targets. Per game, he’s averaging 26.1 yards and 2.3 receptions over 13 games.
  • Kyle Juszczyk has rushed for 14 yards with one touchdown (1.1 yards per game in 13 games).
  • Juszczyk’s 22 receiving targets have led to 18 receptions (1.4 per game) for 174 yards (13.4 per game) and one TD.
  • On defense for the 49ers, Nick Bosa has powered the unit with 40 tackles, 15.0 TFL, and 15.0 sacks in 2022.
  • Fred Warner has 101 tackles, 5.0 TFL, 3.0 sacks, and one interception this season.
  • This season, Dre Greenlaw has put up 2.0 TFL, 109 tackles, and one interception.
  • Talanoa Hufanga has 2.0 sacks in addition to his 3.0 TFL, 74 tackles, and four interceptions this year.


  • Terry McLaurin has recorded 1,015 receiving yards (ninth in the NFL) and three touchdowns on 68 receptions, while being targeted 104 times this season.
  • In eight games, Taylor Heinicke has 1,693 passing yards, while throwing 10 touchdowns against five interceptions and completing 61.4% of his attempts.
  • He has added 100 rushing yards (fourth on the Commanders), while scoring one touchdown on the ground (averaging 12.5 yards per game and 3.8 per carry).
  • Curtis Samuel has totaled 600 receiving yards and three touchdowns on 57 receptions, while being targeted 84 times on the season.
  • In six games, Carson Wentz has 1,489 passing yards, with 10 touchdowns against six interceptions and completing 62.1% of his passes.
  • He has also added 79 rushing yards (sixth on the Commanders), with zero touchdowns on the ground (averaging 13.2 yards per game and 4.2 per carry).
  • Jonathan Allen has intercepted one pass in addition to 57 tackles, 14.0 TFL, 6.5 sacks, and three passes defended in 2022.
  • Da’Ron Payne has 53 tackles, 14.0 TFL, 8.5 sacks, and five passes defended.
  • During the 2022 season, Jamin Davis has 86 tackles, 7.0 TFL, and 3.0 sacks through 14 games.
  • Montez Sweat’s season stats include 39 tackles, 12.0 TFL, and 7.0 sacks through 14 games.

49ers vs. Commanders Predictions and Pick

Our pick to win this game is the 49ers, and we predict that 49ers will cover the spread (49ers -7). Finally, we see the scoring in this one going over the posted total of 38 points.

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How to Bet on 49ers vs. Commanders

You can bet on 49ers vs. Commanders at every legal online sportsbook. For more NFL odds, including moneylines, spreads, over/under totals as well as NFL prop odds, check out the latest NFL lines as well as our guide to the best NFL betting sites.

And if you wanted to check out how much you could win on a $10 bet if you parlayed today’s 49ers vs. Commanders picks, don’t forget to check out our free parlay calculator.

Not sure what a parlay is? Or even how to bet on football? Check out our complete guide to sports betting.


Andy Molitor

Andy has been involved in sports betting on and off his entire adult life and has been creating content surrounding it for the past five years. While the NFL is his first love, he also bets hundreds of college basketball games every winter and loves sweating golf DFS during the football offseason.

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