Chiefs vs Cardinals Prediction: Week 1 Picks, Live Odds & Start Time – September 11, 2022

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State Farm Stadium is where the Arizona Cardinals (0-0) will square off against the Kansas City Chiefs (0-0) on Sunday, September 11, 2022.

Chiefs vs. Cardinals Odds

Point Spread

The spread for this matchup is set at 6.5 points, with bookmakers listing the Chiefs as the favorites.


As for the moneyline, the Chiefs have -265 odds to pick up the win, while the Cardinals are listed at +225 to claim victory.


Finally, the over/under for the game is set at 54 points.

Game Info

How to Watch Chiefs vs. Cardinals Live?

  • Game Day: Sunday, September 11, 2022
  • Game Time: 4:25 PM ET
  • TV Channel: CBS
  • Location: Glendale, Arizona
  • Stadium: State Farm Stadium

Betting Preview


  • The Chiefs, on average, scored 6.7 more points per game last year (28.2) than the Cardinals allowed (21.5).
  • Kansas City was 7-5 against the spread and 9-3 overall last season when the team put up over 21.5 points.
  • The Cardinals’ defense surrendered 329.2 yards per game last year, 67.6 less than the 396.8-yard average from the Chiefs’ offense. The Chiefs picked up 5.9 yards per play and the Cardinals gave up 5.4.
  • In games that Kansas City totaled over 329.2 yards last year, the team was 7-8 against the spread and 10-5 overall.
  • The Chiefs averaged 115.0 yards on the ground last season, just 0.2 yards more than the Cardinals allowed to opposing rushing attacks (114.8).
  • Last year Kansas City had a 4-4 ATS record and a 5-3 overall record in games the team ran for more than 114.8 yards.


  • The Cardinals scored 26.4 points per game last season, 5.0 more than the Chiefs gave up.
  • Arizona was 9-3 against the spread and 10-2 overall in games when it put up more than 21.4 points last year.
  • The Cardinals’ offense gained 373.6 yards per game last year, within 4.7 yards of the 368.9 the Chiefs’ defense conceded. The Cardinals picked up 5.6 yards per play and the Chiefs gave up 5.9.
  • In games that Arizona piled up more than 368.9 yards last season, the team was 7-4 against the spread and 8-3 overall.
  • The Chiefs allowed opposing rushing attacks to average 117.6 yards per game last year, compared to the 122.1 yards the Cardinals picked up on the ground.
  • When Arizona rushed for more than 117.6 yards last year it had a 7-2 ATS record and a 7-2 overall record.

Chiefs vs. Cardinals Injury Report


Chiefs: No Injuries Listed


Cardinals: No Injuries Listed

Chiefs vs. Cardinals Betting Analysis

Chiefs Betting Insights

  • The Chiefs had eight wins in 17 games against the spread last year.
  • The Chiefs’ ATS record as 6.5-point favorites or more was 5-4 last year.
  • Kansas City won 12 of the 17 games it was the moneyline favorite last season (70.6%).
  • Kansas City had an 8-1 record last year (winning 88.9% of its games) when it played as a moneyline favorite of -265 or shorter.
  • The Chiefs had 10 of its 17 games go over the point total last season.

Cardinals Betting Insights

  • Against the spread, the Cardinals were 10-7-0 last year.
  • The Cardinals went unbeaten ATS (1-0) as underdogs of 6.5 points or more last season.
  • Arizona was an underdog six times last season and won six of those games.
  • Arizona was not a bigger underdog last season than the +225 moneyline set for this game.
  • In 17 Cardinals games last year, eight of them went over the total.

Chiefs vs. Cardinals Against The Spread & Betting Records


Overall Home Away
Point Total AVG 51.9 51.2 52.7
Implied Total AVG 29.2 29.3 29.1
ATS Record 8-9-0 4-5-0 4-4-0
Over/Under Record 10-7-0 4-5-0 6-2-0
Moneyline Favorite Record 12-5 7-2 5-3
Moneyline Underdog Record 0-0 0-0 0-0


Overall Home Away
Point Total AVG 48.7 48.3 49.1
Implied Total AVG 27.6 27.5 27.8
ATS Record 10-7-0 2-6-0 8-1-0
Over/Under Record 8-9-0 4-4-0 4-5-0
Moneyline Favorite Record 5-6 3-5 2-1
Moneyline Underdog Record 6-0 0-0 6-0

Players to Watch


  • Patrick Mahomes II averaged 7.4 passing yards per attempt (14th in the NFL) and 284.6 yards per game last year, completing 66.3% of his passes on the way to 4,839 total yards (fourth in the NFL), 37 touchdowns (fourth in the NFL) and 13 interceptions in 17 games.
  • He added 381 yards on the ground, while scoring two rushing touchdowns. He averaged 22.4 yards per game and 5.8 per attempt.
  • Travis Kelce put together a 2021 stat sheet that included 92 catches for 1,125 yards and nine receiving touchdowns (ninth in the NFL) over 16 games played. He was on the receiving end of 134 targets and averaged 5.8 receptions per game.
  • Clyde Edwards-Helaire averaged 51.7 rushing yards per game last season (517 total yards), while scoring four rushing touchdowns.
  • Edwards-Helaire’s stat sheet included 19 receptions (1.9 per game) on 23 targets for 129 yards (12.9 per game) and two receiving touchdowns.
  • Mecole Hardman was targeted 83 times, resulting in 59 catches for 693 yards .
  • Nick Bolton had 11.0 TFL and 112 tackles over 16 games in 2021.
  • L’Jarius Sneed had 76 tackles, 7.0 TFL, 1.0 sack, and two interceptions.
  • Carlos Dunlap had 34 tackles, 8.0 TFL, and 8.5 sacks in 2021 for the Seahawks.
  • Chris Jones had 9.0 sacks as well as 8.0 TFL and 27 tackles.


  • Kyler Murray last season registered 3,787 passing yards with 24 passing touchdowns, 10 interceptions and a 69.2% completion percentage.
  • Murray was a factor with his legs, too, running for 423 yards and five TDs.
  • As a runner, James Conner compiled 752 rushing yards with 15 touchdowns.
  • As a receiver, Conner totaled 37 catches (on 39 targets) for 375 yards and three touchdowns.
  • Darrel Williams scampered for 558 rushing yards (32.8 yards per game) and six touchdowns with the Chiefs last season, averaging 3.9 yards per carry.
  • Williams totaled 47 receptions (on 57 targets) for 452 yards and two touchdowns in addition to the numbers he produced in the ground attack.
  • Marquise Brown was targeted 145 times with the Ravens last season, leading to 91 catches, 1,008 yards and six touchdowns in 16 games.
  • On defense Jalen Thompson, who was on the field for 17 games, amassed 121 tackles, 3.0 TFL, and three interceptions.
  • With one interception to go with 106 tackles, 4.0 TFL, 1.5 sacks, and seven passes defended in 17 games, Isaiah Simmons was an important contributor on defense last season.
  • Budda Baker played in 17 games and delivered three interceptions to go along with 97 tackles, 6.0 TFL, 2.0 sacks, and seven passes defended.
  • Markus Golden totaled 11.0 sacks to go with 10.0 TFL and 48 tackles in 16 games.

Chiefs vs. Cardinals Predictions and Pick

Our prediction to win this contest is the Cardinals, and we expect that Cardinals will cover the spread (Chiefs -6.5). Finally, we see the scoring in this one going under the posted total of 54 points.

How to Bet on Chiefs vs. Cardinals

You can bet on Chiefs vs. Cardinals at every legal online sportsbook. For more NFL odds, including moneylines, spreads, over/under totals as well as NFL prop odds, check out the latest NFL lines as well as our guide to the best NFL betting sites.

And if you wanted to check out how much you could win on a $10 bet if you parlayed today’s Chiefs vs. Cardinals picks, don’t forget to check out our free parlay calculator.

Not sure what a parlay is? Or even how to bet on football? Check out our complete guide to sports betting.


Brian Twining

Sports, of all kind, have been a huge part of my life and daily routine for as long as I can remember. My favorite sports to watch are College Basketball, College Football, the NFL, MLB, Nascar, & the FIFA World Cup. My favorite sports to bet on are the NFL, Nascar, College Hoops, and College Football.

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