49ers vs Cowboys Prediction: NFC Divisional Picks, Live Odds & Start Time

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The Dallas Cowboys (12-5) go on the road in the playoffs against the San Francisco 49ers (13-4) in the NFC Divisional round on Sunday, January 22, 2023 at Levi’s Stadium.

49ers vs. Cowboys Odds

Point Spread

The spread for this matchup is set at 3.5 points, with sportsbooks listing the 49ers as the favorites.


As for the moneyline, the 49ers have -195 odds to pick up the win, while the Cowboys are listed at +165 to claim victory.


Finally, the total for the game is set at 46.5 points.

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Game Info

How to Watch 49ers vs. Cowboys Live?

  • Game Day: Sunday, January 22, 2023
  • Game Time: 6:30 PM ET
  • TV Channel: FOX
  • Location: Santa Clara, California
  • Stadium: Levi’s Stadium

Betting Preview


The 49ers have been making things happen on both sides of the ball this season, as they rank fifth-best in total offense (365.6 yards per game) and best in total defense (300.6 yards allowed per game). The 49ers sport the sixth-ranked offense this year (26.5 points per game), and they’ve been better on defense, ranking best with just 16.3 points allowed per game.

The 49ers are totaling 226.8 passing yards per game on offense, which ranks them 13th in the NFL. Defensively, they rank 20th, giving up 222.9 passing yards per contest. Defensively, the 49ers have been a top-five unit in terms of rushing yards, ranking second-best by giving up just 77.7 per game. They rank eighth on offense (138.8 rushing yards per game).

The 49ers are averaging a 45.0% third-down percentage offensively this year (sixth in NFL), and they are surrendering a 39.0% third-down percentage (16th) on the defensive side of the ball. The 49ers have been clicking on all fronts in terms of yards per play this year, as they rank fourth-best in offensive yards per play (5.9) and third-best in yards per play allowed on defense (5.0). The 49ers have forced 30 total turnovers (second in NFL) this season and have turned it over 17 times (third in NFL) for a turnover margin of +13, the best in the NFL.

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From an offensive standpoint, the Cowboys are posting 354.9 total yards per contest (11th-ranked). They rank 12th in the NFL on the other side of the ball (330.2 total yards given up per game). Things have been positive for the Cowboys on both sides of the ball, as they are averaging 27.5 points per game (fourth-best) and surrendering just 20.1 points per game (fifth-best).

With 219.8 passing yards per game on offense, the Cowboys rank 14th in the NFL. On defense, they rank eighth, giving up 200.9 passing yards per contest. The Cowboys are accumulating 135.2 rushing yards per game on offense this season (ninth-ranked). Meanwhile, they are allowing 129.3 rushing yards per game (22nd-ranked) on defense.

The Cowboys’ third-down offense has been consistently moving the chains, producing a 45.5% third-down conversion rate (fifth-best) this season. On defense, they rank ninth by allowing a 37.7% third-down rate. From an offensive angle, the Cowboys are generating 5.4 yards per play (15th-ranked). They rank seventh in the NFL on the other side of the ball (5.1 yards surrendered per play). The Cowboys sport a top-five turnover margin this season, ranking second-best at +10.

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49ers vs. Cowboys Injury Report


Player Pos. Injury Status
Jimmy Garoppolo QB Foot Out
Ambry Thomas CB Ankle Out


Player Pos. Injury Status
Peyton Hendershot TE Hamstring Questionable
Jason Peters OT Hip Out
Devin Harper LB Achilles Questionable
Simi Fehoko WR Shoulder Questionable
Jason Peters OT Hip Out
Peyton Hendershot TE Hamstring Questionable

49ers vs. Cowboys Betting Analysis

49ers Betting Insights

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The 49ers covered the spread 11 times in 17 games during the regular season. In the postseason, they carry a record of 1-0-0 versus the spread. As 3.5-point favorites or more, the 49ers are 8-4 against the spread (in the regular season and playoffs).

In 17 49ers games in the regular season, nine went over the total. Meanwhile, they have exceeded the point total in one of one game in the postseason. The 49ers won 12 of the 15 games they were listed as the moneyline favorite during the regular season (80%). They are 1-0 as the moneyline favorite in the postseason.

When they have played as a moneyline favorite with odds of -195 or shorter in the regular season and playoffs, the 49ers have a record of 9-2 (81.8%).

Cowboys Betting Insights

The Cowboys beat the spread 10 times in 17 games during the regular season, and are 1-0-0 ATS in the postseason. The Cowboys have two wins ATS (2-1) as 3.5-point underdogs or more in the regular season and playoffs.

There were nine Cowboys games (out of 17) that hit the over in the regular season, and zero (of one) in the playoffs. During the regular season, the Cowboys won three out of five games in which they were the underdogs. They are 0-0 in the playoffs.

The Cowboys have a record of 2-1 when they’ve been underdogs of +165 or more, including the regular season and postseason.

49ers vs. Cowboys Against The Spread & Betting Records


Overall Home Away Playoffs
Point Total AVG 42.2 42.3 42.2 42.0
Implied Total AVG 23.9 24.2 23.5 26.0
ATS Record 11-6-0 7-2-0 4-4-0 1-0-0
Over/Under Record 9-8-0 5-4-0 4-4-0 1-0-0
Moneyline Favorite Record 12-3 8-0 4-3 1-0
Moneyline Underdog Record 1-1 0-1 1-0 0-0


Overall Home Away Playoffs
Point Total AVG 44.3 45.4 43.1 45.5
Implied Total AVG 25.4 26.7 24.0 24.0
ATS Record 10-7-0 6-3-0 4-4-0 1-0-0
Over/Under Record 9-8-0 5-4-0 4-4-0 0-1-0
Moneyline Favorite Record 9-3 7-0 2-3 1-0
Moneyline Underdog Record 3-2 1-1 2-1 0-0

Players to Watch


  • On the ground, Christian McCaffrey averages 4.7 yards per attempt (18th in the NFL) and 67.0 yards per game for 1,139 total rushing yards (eighth in the NFL). He has recorded eight rushing touchdowns this season.
  • He has hauled in 85 passes (on 107 targets) for 741 receiving yards with five touchdowns. He’s averaging 43.6 receving yards and 5.0 catches per game.
  • Brandon Aiyuk has caught 78 passes on 113 targets for 1,015 total yards and eight touchdowns. He is averaging 4.6 catches and 59.7 yards per game in 17 games.
  • In 15 games played, George Kittle is averaging 51.0 yards and 4.0 receptions per game on the way to 765 receiving yards and 60 catches. He’s been targeted 86 times, and has 11 receiving touchdowns (third in the NFL).
  • Deebo Samuel has put up 632 receiving yards and two touchdowns with 56 catches on 95 targets. He’s averaging 4.3 receptions and 48.6 yards per game.
  • Over on the defensive side, Nick Bosa has 49 tackles, 18.0 TFL, and 18.0 sacks in 2022.
  • Fred Warner has picked off one pass and has added 134 tackles, 5.0 TFL, 3.0 sacks, and 10 passes defended.
  • Dre Greenlaw has recorded 124 tackles, 2.0 TFL, and one interception this year.
  • Talanoa Hufanga has four interceptions while also adding 94 tackles, 3.0 TFL, 2.0 sacks, and nine passes defended.


  • Tony Pollard averages 62.9 rushing yards per game this year (1,007 total yards), while scoring nine rushing touchdowns.
  • Pollard’s contributions include 39 receptions (2.4 per game) on 55 targets for 371 yards (23.2 per game) and three receiving touchdowns.
  • In 12 games, Dak Prescott has 2,860 passing yards, with 23 touchdowns against 15 interceptions and completing 66.2% of his attempts.
  • He has added 182 rushing yards (third on the Cowboys), while scoring one touchdown on the ground (averaging 15.2 yards per game and 4.0 per carry).
  • Through 17 games played this season, CeeDee Lamb has 107 catches (6.3 receptions per game on 9.2 targets per game) for 1,359 yards (sixth in the NFL) and nine receiving touchdowns (sixth in the NFL).
  • Ezekiel Elliott averages 58.4 rushing yards per game over 15 games (876 total yards), with 12 rushing touchdowns.
  • Micah Parsons has 64 tackles, 10.0 TFL, 12.5 sacks, and three passes defended in 2022.
  • Donovan Wilson has 97 tackles, 7.0 TFL, 5.0 sacks, and one interception. He leads the Cowboys in tackles.
  • Demarcus Lawrence has 6.0 sacks (third on the Cowboys) in addition to his 8.0 TFL and 64 tackles.
  • Jayron Kearse has intercepted one pass and also has 77 tackles, 7.0 TFL, 2.0 sacks, and five passes defended.

49ers vs. Cowboys Predictions and Pick

Our pick to win this contest is the 49ers, and we project that Cowboys will cover the spread (49ers -3.5). Finally, we see the scoring in this one going under the posted total of 46.5 points.

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How to Bet on 49ers vs. Cowboys

You can bet on 49ers vs. Cowboys at every legal online sportsbook. For more NFL odds, including moneylines, spreads, over/under totals as well as NFL prop odds, check out the latest NFL lines as well as our guide to the best NFL betting sites.

And if you wanted to check out how much you could win on a $10 bet if you parlayed today’s 49ers vs. Cowboys picks, don’t forget to check out our free parlay calculator.

Not sure what a parlay is? Or even how to bet on football? Check out our complete guide to sports betting.


Andy Molitor

Andy has been involved in sports betting on and off his entire adult life and has been creating content surrounding it for the past five years. While the NFL is his first love, he also bets hundreds of college basketball games every winter and loves sweating golf DFS during the football offseason.

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