Duke vs Louisville Prediction: Odds, Picks, Best Bets – Monday, February 20, 2023

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The Duke Blue Devils (19-8, 10-6 ACC) aim to build on a 14-game home winning stretch when hosting the Louisville Cardinals (4-23, 2-14 ACC) on Monday, February 20, 2023 at 7:00 PM ET.

Monday’s matchup between the Blue Devils and the Cardinals features the Blue Devils as mammoth 18-point favorites. The over/under for the game is set at 137.5.

Duke vs. Louisville Odds

Point Spread for Duke vs. Louisville

The spread for this matchup is set at 18 points, with sportsbooks listing Duke as the favorite.

Duke vs. Louisville Moneyline

As for the moneyline, Duke has -2687 odds to pick up the win, while Louisville is listed at +1192 to claim victory.


Finally, the total for the game is set at 137.5 points.

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Game Time and How to Watch

  • Game Day: Monday, February 20, 2023
  • Game Time: 7:00 PM ET
  • TV Channel: ESPN
  • Location: Durham, North Carolina
  • Arena: Cameron Indoor Stadium

Duke vs. Louisville Betting Trends

Duke is 10-17-0 against the spread this year. The Blue Devils have been victorious in 18, or 78.3%, of the 23 contests they have been chosen as favorites in this season. Duke’s games this year have gone over the total in 10 out of 27 opportunities (37%).

Louisville is 11-16-0 against the spread this season. The Cardinals have won three of the 22 games they were listed as the moneyline underdog this season (13.6%). Louisville’s games this season have hit the over on 12 of 27 set point totals (44.4%).

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Duke vs. Louisville Key Players to Watch


Kyle Filipowski leads the Blue Devils with 15.1 points per contest and 9.2 rebounds, while also posting 1.4 assists. Ryan Young puts up 7.7 points, 6.3 rebounds and 1.3 assists per game, shooting 71.7% from the floor. Jeremy Roach leads the Blue Devils at 3.0 assists per contest, while also averaging 2.4 rebounds and 12.7 points. Tyrese Proctor is tops on the Blue Devils at 3.0 assists per contest, while also putting up 3.2 rebounds and 8.8 points.


Jae’Lyn Withers is the Cardinals’ top rebounder (5.3 per game), and he produces 9.6 points and 0.7 assists. The Cardinals get 9.5 points, 3.2 rebounds and 1.1 assists per game from Mike James. JJ Traynor gets the Cardinals 6.1 points, 3.6 rebounds and 0.7 assists per contest. He also puts up 0.4 steals and 0.4 blocked shots.

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What you need to know about the Duke Blue Devils

Duke and its ACC opponents have combined to go over the point total seven out of 16 times this season. With 71.6 points per game on offense, the Blue Devils rank 176th in the nation. Defensively, they cede 64.0 points per contest, which ranks 35th in college basketball. Duke ranks 15th-best in the country by grabbing 36.2 rebounds per game. In terms of rebounds allowed, it ranks 26th in college basketball (27.9 allowed per contest).

The Blue Devils are putting up 76.6 points per game this season when playing at home, which is 7.9 more points than they’re averaging in road games (68.7). Duke is draining 7.0 three-pointers per game (226th-ranked in college basketball) this season, while owning a 33.2% three-point percentage (239th-ranked). This season, the Blue Devils are allowing 6.1 treys per game (47th-ranked in college basketball) and are allowing opponents to shoot 30.4% (28th-ranked) from beyond the arc.

The Blue Devils are 3-7 against the spread and 6-4 overall in their past 10 contests. Duke has gone over the total in three of its past 10 outings. On the offensive side of the ball, Duke has had a hard time putting the ball in the basket over its last 10 games, scoring 69.7 points per contest over that stretch compared to the 71.6 it has put up over the course of this year. Duke’s defense has been less stingy as of late, as the team has given up 65.8 points per game during its last 10 compared to the 64.0 points per game its opponents are averaging this season.

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What you need to know about the Louisville Cardinals

Louisville and its opponents have combined to hit the over eight out of 16 times this year in ACC play. Offensively, the Cardinals are the 23rd-worst squad in the country (64.5 points per game). Defensively, they are 326th (75.4 points allowed per game). Louisville is 272nd in the nation in rebounds per game (30.1) and 188th in rebounds allowed (31.1).

In 2022-23 the Cardinals are averaging 1.9 more points per game at home (66.8) than on the road (64.9). In 2022-23, Louisville is 261st in college basketball in 3-point makes (6.6 per game) and 210th in 3-point percentage (33.7%). In 2022-23, the Cardinals are 285th in the nation in 3-pointers conceded (8.1 per game) and 264th in defensive 3-point percentage (35.0%).

The Cardinals have gone 2-8 over their last 10 contests, with a 5-5 record against the spread in that span. Five of Louisville’s past 10 outings have gone over the total. While Louisville is averaging 64.5 points per game in 2022-23, it has improved that mark in its previous 10 games, amassing 66.9 a contest. While the Cardinals are giving up 75.4 points per game in 2022-23, they have been worse over their past 10 games, allowing 76.3 points per contest.

Duke vs. Louisville Prediction & Pick

Our pick to win this matchup is Duke, and we project that Duke will cover the spread (Duke -18). Finally, we see the scoring in this one going over the posted total of 137.5 points.

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How to bet Duke vs. Louisville

You can bet on Duke vs. Louisville at every legal online sportsbook. For more college basketball odds, including moneylines, spreads, over/under totals, check out the latest NCAA lines as well as our guide to the best college basketball betting sites.

And if you wanted to check out how much you could win on a $10 bet if you parlayed today’s Duke vs. Louisville picks, don’t forget to check out our free parlay calculator.

Not sure what a parlay is? Or even how to bet on college basketball? Check out our complete guide to sports betting.


Dan Weiner

Hailing from Atlanta and attending college at the University of Texas, Dan is passionate about sports, particularly college football and soccer. He's a diehard Atlanta pro sports and Texas Longhorns fan. He likes every sport and will watch anything and everything the weirder the better. He joined Betsperts after an 11 year career in television production at ESPN.

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