Ohio State vs. Iowa Prediction: Picks & Start Time – October 2022

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The No. 2 Ohio State Buckeyes (6-0) face a Big Ten matchup versus the Iowa Hawkeyes (3-3).

Ohio State vs. Iowa Odds

Point Spread

The spread for this matchup is set at 29.5 points, with bookmakers listing Ohio State as the favorites.


As for the moneyline, Ohio State has -11666 odds to pick up the win, while Iowa is listed at +2066 to claim victory.


Finally, the over/under for the game is set at 50 points.

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Game Info

How to Watch Ohio State vs. Iowa Live?

  • Game Day: Saturday, October 22, 2022
  • Game Time: 12:00 PM ET
  • TV Channel: FOX
  • Location: Columbus, Ohio
  • Stadium: Ohio Stadium

Betting Preview

Ohio State

Ohio State has been a handful for opposing teams, ranking top-25 in both total offense (second-best with 543.7 yards per game) and total defense (fifth-best with 253.5 yards allowed per game) this year. Ohio State has been a difficult matchup for opposing teams, as they rank top-25 in both scoring offense (best with 48.8 points per game) and scoring defense (10th-best with 15.7 points allowed per game) this season. Ohio State has been making things happen on both sides of the ball in the passing game this season, ranking 15th-best in passing (315.7 passing yards per game) and seventh-best in passing defense (160.3 passing yards allowed per game). Ohio State has been firing on all cylinders in the running game this year, ranking 15th-best in rushing offense (228.0 rushing yards per game) and ninth-best in rushing defense (93.2 rushing yards allowed per game). Ohio State has been a tough matchup for opposing teams on third down, ranking top-25 in both third-down offense (second-best with a 58.0% third-down conversion rate) and third-down defense (fifth-best with a 27.2% third-down percentage allowed) this year. Ohio State ranks 60th in college football with a +1 turnover margin after forcing 6 turnovers (108th in the FBS) while committing five (11th in the FBS).


Offensively, Iowa is bottom-25, accumulating only 238.8 total yards per game (worst). Fortunately, it is excelling on the defensive side of the ball, surrendering 264.7 total yards per contest (seventh-best). Iowa ranks fifth-worst in points per game on offense (14.7), but at least it has been shutting down opposing offenses on defense, ranking third-best in points allowed per game (9.8). Iowa ranks 12th-worst in passing yards per game on offense (156.7), but at least it has been dominating on the defensive side of the ball, ranking third-best in passing yards allowed per contest (154.0). Iowa ranks fifth-worst in rushing yards per game on offense (82.2), but at least it has been shutting down opposing offenses on the other side of the ball, ranking 25th-best in rushing yards allowed per contest (110.7). Iowa ranks eighth-worst in third-down conversion rate (29.6%), but it has been better defensively, ranking 30th in the FBS with a 32.7% third-down rate allowed. After forcing 10 turnovers (55th in the FBS) and turning the ball over six times (19th in the FBS) this season, Iowa owns the 28th-ranked turnover margin of +4.

Ohio State vs. Iowa Betting Analysis

Ohio State Betting Insights

Ohio State has covered the spread in a matchup three times this season (3-3-0). Ohio State has an ATS record of 1-2 when playing as at least 29.5-point favorites. This season, Ohio State games have hit the over four times. The Buckeyes have not yet lost as the moneyline favorite this season, going 4-0. The Buckeyes have not yet played a game with moneyline odds of -11666 or shorter.

Hawkeyes Betting Insights

Iowa has gone 3-3-0 against the spread this year. Games involving Iowa has hit the over once this year. The Hawkeyes have lost both games they’ve played as underdogs this season. The Hawkeyes have not entered a game this season with longer moneyline odds than +2066.

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Ohio State vs. Iowa Against The Spread & Betting Records

Ohio State

Overall Home Away
Point Total AVG 61.5 60.9 64.5
Implied Total AVG 45.8 45.8 46.0
ATS Record 3-3-0 2-3-0 1-0-0
Over/Under Record 4-2-0 3-2-0 1-0-0
Moneyline Favorite Record 4-0 3-0 1-0
Moneyline Underdog Record 0-0 0-0 0-0


Overall Home Away
Point Total AVG 38.7 40.4 35.3
Implied Total AVG 24.3 26.3 20.5
ATS Record 3-3-0 1-3-0 2-0-0
Over/Under Record 1-5-0 0-4-0 1-1-0
Moneyline Favorite Record 3-1 2-1 1-0
Moneyline Underdog Record 0-2 0-1 0-1

Players to Watch

Ohio State

  • Tommy Eichenberg has helped spur the Buckeyes’ defense with 43 tackles, 5.0 TFL, and 2.5 sacks in six games.
  • With 12 tackles, 5.0 TFL, and 4.5 sacks in six games, Michael Hall Jr. has been a big contributor to the Buckeyes’ defense in 2022.
  • Steele Chambers has helped carry the Buckeyes’ defense with one interception to go along with 26 tackles, 4.0 TFL, one sack, and one pass defended in six games.
  • With 2.0 sacks to go along with 1.0 TFL and 10 tackles, Javontae Jean-Baptiste has helped lead the Buckeyes’ defense over six games.


  • In six games for the Hawkeyes, Cooper DeJean has totaled 25 tackles and three interceptions.
  • On defense, Jack Campbell has helped lead the charge with 36 tackles and 3.0 TFL in six games.
  • The Hawkeyes’ Seth Benson has amassed 33 tackles and 1.0 TFL in six games.
  • On defense, Kaevon Merriweather has compiled 19 tackles, 1.0 TFL, and one interception in six games.

Ohio State vs. Iowa Predictions and Pick

Ohio State vs. Iowa betting card

    Pick ATS:

    Hawkeyes (+29.5)

    Pick OU:

    Under (50)

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How to Bet on Ohio State vs. Iowa

You can bet on Ohio State vs. Iowa at every legal online sportsbook. For more college football odds, including moneylines, spreads, over/under totals as well as college football prop odds, check out the latest college football lines as well as our guide to the best college football betting sites.

And if you wanted to check out how much you could win on a $10 bet if you parlayed today’s Ohio State vs. Iowa picks, don’t forget to check out our free parlay calculator.

Not sure what a parlay is? Or even how to bet on college football? Check out our complete guide to sports betting.

Our prediction to win this matchup is Ohio State, and we project that Iowa will cover the spread (Ohio State -29.5). Finally, we see the scoring in this one going under the posted total of 50 points.


Matt Rooney

Matt comes from Chicago and has lived in the area his whole life. Graduated from and played football at Illinois Wesleyan University in Bloomington, IL while also serving as the director of student sports broadcasting. He writes for Betsperts as well as appears on several shows across the network.

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