Northwestern Wildcats vs. Duke Blue Devils Picks and Prediction – September 10

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The Northwestern Wildcats (1-0) and Duke Blue Devils (1-0) will face each other in a matchup at Ryan Field in Evanston, Illinois.

Northwestern vs. Duke Odds

Point Spread

The spread for this matchup is set at 10.5 points, with bookmakers listing Northwestern as the favorites.


As for the moneyline, Northwestern has -391 odds to pick up the win, while Duke is listed at +287 to claim victory.


Finally, the total for the game is set at 57 points.


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Game Info

How to Watch Northwestern vs. Duke Live?

  • Game Day: Saturday, September 10, 2022
  • Game Time: 12:00 PM ET
  • TV Channel: Fox Sports 1
  • Location: Evanston, Illinois
  • Stadium: Ryan Field

Betting Preview


  • Northwestern averaged 23.2 fewer points per game (16.6) than Duke allowed (39.8) last year.
  • Northwestern collected 195.7 fewer yards per game (321.5) than Duke allowed per matchup (517.2) last season.
  • Last season Northwestern averaged 144.2 yards per game on the ground, 61.2 fewer than Duke allowed per outing (205.4).
  • When the Wildcats ran for more than 205.4 yards last year, they had a 1-1 ATS record and a 2-0 overall record.


  • Last year Duke racked up 6.2 fewer points per game (22.8) than Northwestern allowed (29.0).
  • The Blue Devils were 3-0 against the spread and 3-0 overall last season when the team scored over 29.0 points.
  • Duke racked up 418.8 yards per game last season, only 10.7 fewer than the 429.5 Northwestern allowed per contest.
  • When the Blue Devils picked up over 429.5 yards last year, the team was 4-2 against the spread and 3-3 overall.
  • Duke rushed for 180.8 yards per game last year, 32.2 fewer than the 213.0 Northwestern allowed per outing.
  • Last year the Blue Devils had a 1-1 ATS record and a 1-1 overall record in games the team rushed for over 213.0 yards.

Northwestern vs. Duke Betting Analysis

Northwestern Betting Insights

  • Northwestern’s record against the spread last season was 3-9-0.
  • Northwestern had one win ATS (1-1) as a 10.5-point favorite or more last year.
  • The Wildcats were favored on the moneyline three total times last season. They finished 1-2 in those games.
  • The Wildcats played as a moneyline favorite of -391 or shorter in just one game last season, which they won.
  • Northwestern had six of its 12 games go over the point total last year.

Blue Devils Betting Insights

  • Duke’s record against the spread last season was 4-8-0.
  • Duke had no wins ATS (0-7) as underdogs of 10.5 points or more last year.
  • The Blue Devils were underdogs in nine games last season and won one (11.1%) of those contests.
  • Last season, the Blue Devils were at least a +287 underdog on the moneyline seven times, losing each of those contests.
  • In 12 Duke games last season, six of them hit the over.

Northwestern vs. Duke Against The Spread & Betting Records


Overall Home Away
Point Total AVG 46.2 45.1 47.6
Implied Total AVG 29.4 28.4 30.8
ATS Record 3-9-0 3-4-0 0-5-0
Over/Under Record 6-6-0 2-5-0 4-1-0
Moneyline Favorite Record 1-2 1-1 0-1
Moneyline Underdog Record 1-7 1-3 0-4

Blue Devils

Overall Home Away
Point Total AVG 61.6 59.2 64.9
Implied Total AVG 38.1 37.4 39.0
ATS Record 4-8-0 4-3-0 0-5-0
Over/Under Record 6-6-0 5-2-0 1-4-0
Moneyline Favorite Record 2-1 2-0 0-1
Moneyline Underdog Record 1-8 1-4 0-4

Last Season’s Leaders


  • Chris Bergin delivered 105 tackles, 1.0 TFL, and 0.5 sacks in 12 games last year.
  • On defense in 2021, Brandon Joseph had 57 tackles, 1.0 TFL, one sack, and three interceptions in 12 games played.
  • Bryce Gallagher recorded 73 tackles, 4.0 TFL, and one sack in 12 games a season ago.
  • Coco Azema totaled 1.0 TFL and 58 tackles in 12 games.

Blue Devils

  • On defense Shaka Heyward, who played in 12 games, posted 61 tackles, 7.0 TFL, three sacks, and one interception.
  • DeWayne Carter, who was on the field for 12 games, registered 4.5 sacks to go with 4.0 TFL and 25 tackles.
  • R.J. Oben was on the field for 12 games and collected one interception to go along with 16 tackles, 3.0 TFL, five sacks, and one pass defended.
  • Lummie Young IV was a big player on D last year, with one interception to go with 38 tackles, one sack, and one pass defended.

Northwestern vs. Duke Predictions and Pick

Our prediction to win this matchup is Northwestern, and we expect that Northwestern will cover the spread (Northwestern -10.5). Finally, we see the scoring in this one going under the posted total of 57 points.

Northwestern vs. Duke betting card

    Pick ATS:

    Wildcats (-10.5)

    Pick OU:

    Under (57)

How to Bet on Northwestern vs. Duke

You can bet on Northwestern vs. Duke at every legal online sportsbook. For more college football odds, including moneylines, spreads, over/under totals as well as college football prop odds, check out the latest college football lines as well as our guide to the best college football betting sites.

And if you wanted to check out how much you could win on a $10 bet if you parlayed today’s Northwestern vs. Duke picks, don’t forget to check out our free parlay calculator.

Not sure what a parlay is? Or even how to bet on college football? Check out our complete guide to sports betting.


Dan Weiner

Hailing from Atlanta and attending college at the University of Texas, Dan is passionate about sports, particularly college football and soccer. He's a diehard Atlanta pro sports and Texas Longhorns fan. He likes every sport and will watch anything and everything the weirder the better. He joined Betsperts after an 11 year career in television production at ESPN.

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