Missouri vs. Vanderbilt Prediction: Picks & Start Time – October 2022

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The Missouri Tigers (2-4) and Vanderbilt Commodores (3-4) will face each other in clash of SEC foes at Faurot Field at Memorial Stadium in Columbia, Missouri.

Missouri vs. Vanderbilt Odds

Point Spread

The spread for this matchup is set at 13.5 points, with sportsbooks listing Missouri as the favorites.


As for the moneyline, Missouri has -558 odds to pick up the win, while Vanderbilt is listed at +405 to claim victory.


Finally, the over/under for the game is set at 49.5 points.


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Game Info

How to Watch Missouri vs. Vanderbilt Live?

  • Game Day: Saturday, October 22, 2022
  • Game Time: 4:00 PM ET
  • TV Channel: SEC Network
  • Location: Columbia, Missouri
  • Stadium: Faurot Field at Memorial Stadium

Betting Preview


On defense, Missouri has been a top-25 unit, ranking 25th-best by allowing just 330.5 yards per game. The offense ranks 82nd (373.8 yards per game). Missouri is putting up 25.2 points per game on offense this season (94th in the FBS), and is giving up 24.7 points per game (58th) on the defensive side of the ball. On defense, Missouri has been a top-25 unit in terms of passing yards, ranking 24th-best by giving up only 191.2 passing yards per game. The Tigers rank 104th on offense (206.8 passing yards per game). From an offensive standpoint, Missouri ranks 57th in the FBS with 167.0 rushing yards per game. Meanwhile, the defensive unit ranks 59th in rushing yards allowed per contest (139.3). Missouri has the 89th-ranked offense this season in terms of third-down efficiency (37.2% percentage), and has been better on the other side of the ball, ranking seventh-best with a 27.7% third-down conversion rate allowed. Missouri ranks 100th in college football with a -1 turnover margin after forcing 10 turnovers (55th in the FBS) while committing 11 (88th in the FBS).


Vanderbilt ranks 104th in total yards per game (347.0), but it has been less effective on the other side of the ball, ranking third-worst in the FBS with 493.7 total yards allowed per contest. Vanderbilt’s defense has been bottom-25 in scoring defense this season, allowing 39.4 points per game, which ranks second-worst in the FBS. On the offensive side of the ball, it ranks 71st with 28.4 points per contest. Vanderbilt’s defense has been a bottom-25 unit in pass defense this season, ceding 333.0 passing yards per game, which ranks second-worst in the FBS. Offensively, it ranks 106th with 197.0 passing yards per contest. In terms of rushing, Vanderbilt ranks 70th in the FBS on offense (150.0 rushing yards per game) and 87th on defense (160.7 rushing yards allowed per game). Vanderbilt has been struggling on third down, ranking 17th-worst with a 45.1% third-down conversion rate allowed per game. It has been better on the other side of the ball, compiling a 34.0% third-down rate (101st-ranked). Vanderbilt owns a +2 turnover margin this season, which ranks 43rd in the FBS.

Missouri vs. Vanderbilt Betting Analysis

Missouri Betting Insights

Missouri has gone 4-2-0 against the spread this season. Missouri has an ATS record of 1-1 when playing as at least 13.5-point favorites. Games involving Missouri have hit the over once this season. The Tigers have been the moneyline favorite only one other time so far this season, a game they won. The Tigers have played as a moneyline favorite of -558 or shorter in just one game this season, which they won.

Commodores Betting Insights

Vanderbilt has covered the spread two times in seven games with a set number. Vanderbilt has yet to cover a spread when playing as at least 13.5-point underdogs (0-4). Vanderbilt games have gone over the total five times this year. The Commodores have been underdogs in four games this season and won one (25%) of those contests. The Commodores have been at least a +405 moneyline underdog three times this season, but lost all of those games.


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Missouri vs. Vanderbilt Against The Spread & Betting Records


Overall Home Away
Point Total AVG 55.4 57.8 53.0
Implied Total AVG 37.0 43.0 31.0
ATS Record 4-2-0 2-1-0 2-1-0
Over/Under Record 1-5-0 1-2-0 0-3-0
Moneyline Favorite Record 1-0 1-0 0-0
Moneyline Underdog Record 0-4 0-1 0-3


Overall Home Away
Point Total AVG 58.0 58.5 57.6
Implied Total AVG 39.0 37.3 40.3
ATS Record 2-5-0 0-3-0 2-2-0
Over/Under Record 5-2-0 3-0-0 2-2-0
Moneyline Favorite Record 2-0 1-0 1-0
Moneyline Underdog Record 1-3 0-2 1-1

Players to Watch


  • Ty’Ron Hopper has hit the gridiron for six games, registering 2.0 sacks to go with 4.0 TFL, seven tackles, and one interception for the Tigers.
  • With one interception to go with 11 tackles, 3.0 TFL, one sack, and one pass defended in six games, Jaylon Carlies has been a key piece of the Tigers’ defensive unit in 2022.
  • The Tigers’ defense has been helped by the contributions of Ennis Rakestraw Jr., who has played six games and posted one interception to go along with six tackles and two passes defended.
  • With 2.0 sacks to go along with 3.0 TFL and five tackles, Isaiah McGuire has helped carry the Tigers’ defense over six games.


  • In seven games for the Commodores, Anfernee Orji has delivered 2.0 TFL and 44 tackles.
  • The Commodores’ De’Rickey Wright has amassed 1.0 TFL, 17 tackles, and three interceptions in seven games.
  • The Commodores’ Kane Patterson has delivered 16 tackles, 3.0 TFL, and 1.5 sacks in seven games.
  • With 21 tackles in seven games, Max Worship has been wreaking havoc on defense for the Commodores.

Missouri vs. Vanderbilt Predictions and Pick

Missouri vs. Vanderbilt betting card

    Pick ATS:

    Commodores (+13.5)

    Pick OU:

    Over (49.5)


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How to Bet on Missouri vs. Vanderbilt

You can bet on Missouri vs. Vanderbilt at every legal online sportsbook. For more college football odds, including moneylines, spreads, over/under totals as well as college football prop odds, check out the latest college football lines as well as our guide to the best college football betting sites.

And if you wanted to check out how much you could win on a $10 bet if you parlayed today’s Missouri vs. Vanderbilt picks, don’t forget to check out our free parlay calculator.

Not sure what a parlay is? Or even how to bet on college football? Check out our complete guide to sports betting.

Our pick to win this contest is Missouri, and we project that Vanderbilt will cover the spread (Missouri -13.5). Finally, we see the scoring in this one going over the posted total of 49.5 points.


Dan Weiner

Hailing from Atlanta and attending college at the University of Texas, Dan is passionate about sports, particularly college football and soccer. He's a diehard Atlanta pro sports and Texas Longhorns fan. He likes every sport and will watch anything and everything the weirder the better. He joined Betsperts after an 11 year career in television production at ESPN.

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