Louisville Cardinals vs. Syracuse Orange Picks and Prediction – September 3

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ACC opponents will clash when the Louisville Cardinals (0-0) meet the Syracuse Orange (0-0).

Louisville vs. Syracuse Odds

Point Spread

The spread for this matchup is set at 5.5 points, with sportsbooks listing Louisville as the favorites.


As for the moneyline, Louisville has -209 odds to pick up the win, while Syracuse is listed at +168 to claim victory.


Finally, the total for the game is set at 55.5 points.


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Game Info

How to Watch Louisville vs. Syracuse Live?

  • Game Day: Saturday, September 3, 2022
  • Game Time: 8:00 PM ET
  • TV Channel: ACC Network
  • Location: Syracuse, New York
  • Stadium: JMA Wireless Dome

Betting Preview


  • Louisville put up 31.6 points per game last year, 5.3 more than Syracuse gave up per outing (26.3).
  • The Cardinals were 6-2 against the spread and 6-2 overall last season when the team put up more than 26.3 points.
  • Louisville averaged 446.6 yards per game last season, 116.2 more yards than the 330.4 Syracuse gave up per matchup.
  • In games that the Cardinals picked up more than 330.4 yards last year, the team was 6-6 against the spread and 6-6 overall.
  • Last season Louisville racked up 210.2 yards per game on the ground, 84.0 more than Syracuse allowed per contest (126.2).
  • The Cardinals had a 6-6 ATS record and a 6-6 overall record when the team ran for over 126.2 yards last year.


  • Syracuse racked up just 2.4 fewer points per game (24.9) than Louisville allowed (27.3) last season.
  • The Orange were 5-0 against the spread and 3-2 overall last season when the team scored over 27.3 points.
  • Syracuse averaged 36.8 fewer yards per game (366.5) than Louisville gave up per outing (403.3) last year.
  • In games that the Orange churned out more than 403.3 yards last season, the team was 3-0 against the spread and 2-1 overall.
  • Last season Syracuse averaged 213.5 rushing yards per game, 55.8 more than Louisville allowed per contest (157.7).
  • When the Orange rushed for more than 157.7 yards last season they had an 8-1 ATS record and a 5-4 overall record.

Louisville vs. Syracuse Betting Analysis

Louisville Betting Insights

  • Louisville had six wins in 13 games against the spread last year.
  • Louisville won once ATS (1-1) when favored by 5.5 points or more last season.
  • The Cardinals won four of the six games they were the moneyline favorite last season (66.7%).
  • The Cardinals played as a moneyline favorite of -209 or shorter in only one game last season, which they won.
  • In 13 Louisville games last year, six went over the total.

Orange Betting Insights

  • Against the spread, Syracuse was 8-4-0 last season.
  • Syracuse had an ATS record of 4-2 as underdogs of 5.5 points or more last year.
  • Last season, the Orange won three out of the 10 games in which they were the underdog.
  • The Orange had a record of 0-5 when they were set as an underdog of +168 or more by bookmakers last season.
  • Last year, five of Syracuse’s 12 games hit the over.

Louisville vs. Syracuse Against The Spread & Betting Records


Overall Home Away
Point Total AVG 60.5 58.8 63.1
Implied Total AVG 33.9 32.9 35.6
ATS Record 6-7-0 3-5-0 3-2-0
Over/Under Record 6-7-0 4-4-0 2-3-0
Moneyline Favorite Record 4-2 2-2 2-0
Moneyline Underdog Record 1-5 1-2 0-3


Overall Home Away
Point Total AVG 51.4 51.3 51.6
Implied Total AVG 29.8 30.6 28.6
ATS Record 8-4-0 5-2-0 3-2-0
Over/Under Record 5-7-0 2-5-0 3-2-0
Moneyline Favorite Record 2-0 2-0 0-0
Moneyline Underdog Record 3-7 1-4 2-3

Last Season’s Leaders


  • Yasir Abdullah had 63 tackles, 17.0 TFL, and 10 sacks last year.
  • In 13 games in 2021, C.J. Avery delivered 97 tackles, 5.0 TFL, and three sacks.
  • In 13 games a season ago, Qwynnterrio Cole registered 85 tackles, 2.0 TFL, and one interception.
  • On defense in 2021, Kenderick Duncan Jr. supplied 74 tackles, 3.0 TFL, one sack, and one interception through 13 games.


  • With 3.0 sacks to go with 8.0 TFL and 83 tackles in 12 games, Mikel Jones was an important player on defense.
  • Cody Roscoe accumulated 8.5 sacks to go along with 9.0 TFL and 43 tackles in 12 games.
  • With 57 tackles, 5.0 TFL, and 4.5 sacks, Stefon Thompson was a big contributor last season on defense.
  • Marlowe Wax registered 6.0 sacks to go with 7.0 TFL and 42 tackles in 12 games.

Louisville vs. Syracuse Predictions and Pick

Our prediction to win this game is Louisville, and we predict that Syracuse will cover the spread (Louisville -5.5). Finally, we see the scoring in this one going under the posted total of 55.5 points.

Louisville vs. Syracuse betting card

    Pick ATS:

    Orange (+5.5)

    Pick OU:

    Under (55.5)

How to Bet on Louisville vs. Syracuse

You can bet on Louisville vs. Syracuse at every legal online sportsbook. For more college football odds, including moneylines, spreads, over/under totals as well as college football prop odds, check out the latest college football lines as well as our guide to the best college football betting sites.

And if you wanted to check out how much you could win on a $10 bet if you parlayed today’s Louisville vs. Syracuse picks, don’t forget to check out our free parlay calculator.

Not sure what a parlay is? Or even how to bet on college football? Check out our complete guide to sports betting.


Dan Weiner

Hailing from Atlanta and attending college at the University of Texas, Dan is passionate about sports, particularly college football and soccer. He's a diehard Atlanta pro sports and Texas Longhorns fan. He likes every sport and will watch anything and everything the weirder the better. He joined Betsperts after an 11 year career in television production at ESPN.

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