Cardinals vs Cubs Prediction: Picks, Live Odds & Start Time – August 22, 2022

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The St. Louis Cardinals (69-51) will visit the Chicago Cubs (52-68), Monday at 8:05 PM ET, in a battle of NL Central rivals. Jordan Montgomery (6-3) is the starter for the Cardinals, and Drew Smyly (5-6) for the Cubs.

Even though the Cardinals are playing on the road at the Cubs, they are currently favored on the moneyline at -174, compared to the home team at +146. The game has an over/under set at 8 runs.

Cardinals vs. Cubs Odds

Run Line

St. Louis Cardinals (-1.5)


Cardinals (-174)


8 Runs (Over: -112, Under: -109)

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When, Where, at What Time is Cardinals vs. Cubs

  • Game Day: Monday, August 22, 2022
  • Game Time: 8:05 PM ET
  • Location: Chicago, Illinois
  • Stadium: Wrigley Field

Cardinals Injury Report

Steven Matz15 Day Injury ListKnee
Jack Flaherty60 Day Injury ListShoulder
Drew VerHagen60 Day Injury ListHip
Álex Reyes60 Day Injury ListShoulder
Ryan HelsleyPaternity ListPersonal
Yadier MolinaRestricted ListPersonal

Cubs Injury Report

Jason Heyward10 Day Injury ListKnee
Wade Miley15 Day Injury ListShoulder
Kyle Hendricks15 Day Injury ListShoulder
Alec Mills15 Day Injury ListBack
Keegan Thompson15 Day Injury ListBack
Brad Wieck60 Day Injury ListElbow
Michael Hermosillo60 Day Injury ListQuadricep
Adbert Alzolay60 Day Injury ListShoulder
Codi Heuer60 Day Injury ListElbow
Ethan Roberts60 Day Injury ListElbow
Manuel Rodriguez60 Day Injury ListElbow

Last Time Out: Cardinals and Cubs

The Cardinals won their last contest versus the Diamondbacks by a 6-4 score yesterday, with Jake Woodford picking up the win pitching going one inning without giving up an earned run on one hit. Lars Nootbaar went 1-for-3 with a home run and an RBI to lead them offensively.

The Cubs were defeated by the Brewers 5-2 yesterday. Seiya Suzuki led the way offensively after going 3-for-3 with a double, a home run and an RBI, and Rowan Wick was handed the loss, throwing one inning, giving up one earned run on one hit.

Betting Trends

Cardinals Betting Records and Team Stats

The Cardinals have been favorites in 67 games this season and won 46 (68.7%) of those contests. St. Louis has a record of 13-5 in games where sportsbooks favor them by at least -174 on the moneyline. The sportsbooks’ moneyline implies a 63.5% chance of a victory for the Cardinals. St. Louis’ games have gone over the total in 57 of their 120 chances. In 120 games with a spread this season, the Cardinals are 68-52-0 ATS.

NameGPAVG (Rank)OBP (Rank)SLG (Rank)HR% (Rank)K% (Rank)BB% (Rank)
Paul Goldschmidt114.340 (1).422 (1).636 (2)6.3% (5)20.4% (81)12.1% (13)
Nolan Arenado112.299 (13).361 (23).556 (5)5.3% (15)12.8% (15)8.4% (75)
Tommy Edman116.254 (75).318 (90).367 (123)1.7% (115)17.6% (51)8.1% (81)
Dylan Carlson100.243 (99).314 (99).392 (103)2.0% (109)18.5% (63)8.1% (81)
Brendan Donovan88.297 (-).408 (-).390 (-)0.6% (-)17.0% (-)12.9% (-)

Cubs Betting Records and Team Stats

The Cubs have come away with 35 wins in the 82 contests they have been listed as the underdogs in this season. Chicago has a win-loss record of 8-17 when favored by +146 or worse by bookmakers this year. Sportsbooks have implied with the moneyline set for this matchup that the Cubs have a 40.7% chance of pulling out a win. Chicago and its opponents have gone over the total this season in 51 of their 120 opportunities. The Cubs have posted a record of 62-58-0 against the spread this season.

NameGPAVG (Rank)OBP (Rank)SLG (Rank)HR% (Rank)K% (Rank)BB% (Rank)
Willson Contreras101.250 (87).359 (25).476 (30)4.5% (27)21.0% (86)9.5% (54)
Ian Happ117.279 (36).353 (28).452 (46)2.7% (88)23.9% (104)9.6% (49)
Nico Hoerner105.293 (20).342 (53).414 (78)1.7% (115)11.5% (7)5.7% (124)
Patrick Wisdom114.219 (129).314 (99).444 (52)4.8% (21)33.6% (143)10.9% (30)
Christopher Morel77.259 (-).326 (-).461 (-)3.8% (-)31.0% (-)8.6% (-)

Cardinals vs. Cubs Picks and Predictions

We predict that the Cardinals will pick up the win in this contest, and they’re our choice on the moneyline (-174). If you’re looking for a pick on the over/under, we predict the final scoring winding up over the total (8 runs).

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Matt Rooney

Matt comes from Chicago and has lived in the area his whole life. Graduated from and played football at Illinois Wesleyan University in Bloomington, IL while also serving as the director of student sports broadcasting. He writes for Betsperts as well as appears on several shows across the network.

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