White Sox vs Guardians Today: Picks, Predictions, Moneyline and Odds – Wednesday, September 21

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On Wednesday, the Chicago White Sox (76-72) are hosting the Cleveland Guardians (81-67), at 8:10 PM ET, in the second game of a three-game set. The starting pitchers are Lance Lynn (7-5) for the White Sox, and Triston McKenzie (10-11) for the Guardians.

The Guardians (+113) take their show on the road to face the favored White Sox (-133). The over/under in this contest is 7.5.

White Sox vs. Guardians Odds

Run Line

Chicago White Sox (-1.5)

Moneyline

White Sox (-133)

Total

7.5 Runs (Over: -113, Under: -108)

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Following Opt-In, you’ll be issued with one (1) single-use Odds Boost to use on ‘Point Total Over 0.5’ in the West Virginia vs. Pittsburgh game (located under ‘DK Specials’)

When, Where, at What Time is White Sox vs. Guardians

  • Game Day: Wednesday, September 21, 2022
  • Game Time: 8:10 PM ET
  • Location: Chicago, Illinois
  • Stadium: Guaranteed Rate Field

White Sox Injury Report

Name Status Injury
Tim Anderson 10 Day Injury List Hand
Michael Kopech 15 Day Injury List Shoulder
Danny Mendick 60 Day Injury List Knee
Kyle Crick 60 Day Injury List Elbow
Garrett Crochet 60 Day Injury List Elbow
Jonathan Stiever 60 Day Injury List Back
Luis Robert Day-to-day Hand / Wrist
Joe Kelly Bereavement List Personal

Guardians Injury Report

Name Status Injury
Aaron Civale 15 Day Injury List Arm
Zach Plesac 15 Day Injury List Hand
Anthony Gose 60 Day Injury List Tricep

Last Time Out: White Sox and Guardians

The Guardians took down the White Sox 10-7 yesterday, with Emmanuel Clase getting the win (1.00 IP, 1 R, 2 H, 1 K) and Steven Kwan leading the way offensively (going 4-for-5 with two RBI). Jake Diekman (1.00 IP, 3 R, 3 H, 1 K) took the loss for the White Sox.

Betting Trends

White Sox Betting Records and Team Stats

This season, the White Sox have won 55 out of the 102 games, or 53.9%, in which they’ve been favored. Chicago is 44-35 this season when entering a game favored by -133 or more on the moneyline. The implied probability of a win from the White Sox, based on the moneyline, is 57.1%. Games involving Chicago have gone over the total set by bookmakers in 67 of 152 chances this season. The White Sox have an ATS record of 70-82-0 in 152 games with a spread this season.

Name GP AVG (Rank) OBP (Rank) SLG (Rank) HR% (Rank) K% (Rank) BB% (Rank)
José Abreu 146 .308 (7) .383 (8) .451 (50) 2.4% (92) 16.7% (39) 9.4% (51)
Andrew Vaughn 123 .285 (25) .336 (54) .455 (43) 3.3% (60) 15.9% (31) 5.6% (118)
Elvis Andrus 135 .260 (69) .317 (90) .415 (80) 2.7% (82) 15.5% (28) 7.4% (84)
A.J. Pollock 126 .246 (88) .292 (120) .391 (103) 2.7% (82) 19.0% (63) 6.0% (114)
Luis Robert 97 .284 (-) .319 (-) .426 (-) 3.0% (-) 19.2% (-) 4.2% (-)

Guardians Betting Records and Team Stats

The Guardians have been victorious in 33, or 43.4%, of the 76 contests they have been chosen as underdogs in this season. This season, Cleveland has been victorious 24 times in 53 chances when named as an underdog of at least +113 or longer on the moneyline. The moneyline set for this matchup implies the Guardians have a 46.9% chance of walking away with the win. Cleveland and their opponents have gone over in 69 of their 152 games with a total set by sportsbooks this season. The Guardians have an against the spread mark of 78-74-0 in 152 games with a line this season.

Name GP AVG (Rank) OBP (Rank) SLG (Rank) HR% (Rank) K% (Rank) BB% (Rank)
José Ramírez 144 .277 (32) .357 (26) .522 (10) 4.5% (28) 11.4% (7) 10.4% (35)
Steven Kwan 134 .296 (14) .373 (13) .387 (107) 0.7% (129) 9.2% (2) 10.2% (37)
Amed Rosario 141 .281 (28) .313 (93) .404 (89) 1.8% (113) 16.6% (38) 4.0% (132)
Andrés Giménez 135 .296 (14) .366 (17) .471 (28) 3.2% (66) 19.2% (65) 6.1% (112)
Josh Naylor 115 .257 (-) .315 (-) .447 (-) 4.0% (-) 15.6% (-) 6.8% (-)

White Sox vs. Guardians Picks and Predictions

Our pick for this matchup is the White Sox to win (-133 on the moneyline), while we project the total score will go over the total (7.5 runs).

DraftKings Double your money if there is a point scored in the West Virginia v Pitt Game (9/1) in Kansas
Double Your Money!
Why claim this offer

Following Opt-In, you’ll be issued with one (1) single-use Odds Boost to use on ‘Point Total Over 0.5’ in the West Virginia vs. Pittsburgh game (located under ‘DK Specials’)

WRITTEN BY

Stacy Sailer

Stacy has been a baseball fan for as long as she can remember. She admits that she grew up as a spoiled Yankees fan in the late-90’s/early 2000’s, but has slowly evolved into a disgruntled Yankees fan due to their lone championship title in the last 21 seasons. She follows other sports, but her first love has always been baseball and loves getting to share her insight and knowledge with the Betsperts community.

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