At 4:05 PM ET on Sunday, the San Francisco 49ers (2-2) take on the Carolina Panthers (1-3).
The 49ers rank 27th in points scored this season (17.8 points per game), but they’ve been thriving on defense, ranking best in the NFL with 11.5 points allowed per game. The Panthers rank worst in total yards per game (262.3), but they’ve been more effective on the other side of the ball, ranking 18th in the NFL with 346.0 total yards surrendered per contest.
Looking to wager on player props in this contest between the 49ers and the Panthers? Keep reading for player props for the best contributors.
49ers Player Props
Deebo Samuel Prop Bets
Over/Under | Over Payout | 2022 Total (Per Game) | |
---|---|---|---|
Rec. Yds | 69.5 | -113 | 246 (61.5) |
- The 49ers’ aerial attack has been aided by Samuel, who has grabbed 18 balls on 29 targets for 246 yards and one touchdown.
- Samuel has hit the over on his prop bets for receiving yards twice in four games this year (50.0%).
- Samuel has one touchdown catch this season, in four games.

Jimmy Garoppolo Prop Bets
Over/Under | Over Payout | 2022 Total (Per Game) | |
---|---|---|---|
Pass Yds | 236.5 | -113 | 604 (201.3) |
Pass TDs | 1.5 | -109 | 3 (1) |
Rush Yds | 5.5 | -118 | 8 (2.7) |
- In three games, Garoppolo has passed for 604 yards (201.3 yards per game) to go along with three touchdowns, one interception, and a completion percentage of 61.0%.
- As a runner, Garoppolo has rushed for 8 yards (1.3 YPC) and one touchdown.
- Garoppolo has gone over on his passing yards prop bets one time this season.
- Garoppolo has a passing touchdown in all three games this year, but no games with more than one passing TD.

Panthers Player Props
Christian McCaffrey Prop Bets
Over/Under | Over Payout | 2022 Total (Per Game) | |
---|---|---|---|
Rush Yds | 67.5 | -110 | 270 (67.5) |
Rush TDs | 0.5 | -115 | 1 (0.2) |
Rec. Yds | 36.5 | -119 | 138 (34.5) |
- McCaffrey has run for 270 yards (67.5 per game) and one touchdown in four games.
- McCaffrey also has 19 catches for 138 yards and one TD.
- McCaffrey hit his rushing yards over two times in four games played this season.
- McCaffrey has a rushing touchdown in one game this year, but no games with multiple rushing TDs.

Baker Mayfield Prop Bets
Over/Under | Over Payout | 2022 Total (Per Game) | |
---|---|---|---|
Pass Yds | 197.5 | -113 | 747 (186.8) |
Pass TDs | 1.5 | +110 | 4 (1) |
Rush Yds | 11.5 | -111 | 40 (10.0) |
- In four games, Mayfield has thrown for 747 yards (186.8 per game), with four touchdowns and three interceptions, and a completion percentage of 54.7%.
- On the ground, Mayfield has scored one touchdown and picked up 40 yards.
- Mayfield has yet to go over on his passing yards prop bet this season in four chances.
- Mayfield has a passing touchdown in all four games this season, but no games with more than one passing TD.

How to Bet on 49ers vs. Panthers Player Props
You can bet on NFL player props from the 49ers vs. Panthers matchup at every legal online sportsbook. For more NFL odds, including game moneylines, spreads, and over/under totals, check out the latest NFL lines as well as our guide to the best NFL betting sites.
And if you wanted to check out how much you could win on a $10 bet if you parlayed today’s 49ers vs. Panthers player props, don’t forget to check out our free parlay calculator.
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