The San Francisco 49ers (4-4) are in action on Sunday at 8:20 PM ET against the Los Angeles Chargers (5-3) at Levi’s Stadium.
On offense, the 49ers rank 19th in the NFL with 22.0 points per game. Meanwhile, they rank sixth in points allowed (285.9 points allowed per contest). From an offensive perspective, the Chargers are putting up 364.3 total yards per contest (ninth-ranked). They rank 21st in the NFL on defense (352.3 total yards surrendered per game).
Before making a player prop wager, keep reading for player props for the best contributors in this outing between the 49ers and the Chargers.
49ers Player Props
Christian McCaffrey Prop Bets
Over/Under | Over Payout | 2022 Total (Per Game) | |
---|---|---|---|
Rush Yds | 80.5 | -127 | 525 (65.6) |
Rec. Yds | 36.5 | -114 | 356 (44.5) |
- In eight games for the 49ers, McCaffrey has tallied 525 rushing yards and three touchdowns while averaging 4.7 yards per carry.
- McCaffrey has made a difference in the receiving game, reeling in 43 balls on 53 targets for 356 yards and two touchdowns.
- McCaffrey has hit the rushing yards over in seven of 10 opportunities (70.0%).
- McCaffrey has rushed for a score in three of his games this year but has yet to score more than once in a single contest.

Jimmy Garoppolo Prop Bets
Over/Under | Over Payout | 2022 Total (Per Game) | |
---|---|---|---|
Pass Yds | 243.5 | -110 | 1691 (241.6) |
Pass TDs | 1.5 | -117 | 11 (1.6) |
Rush Yds | 1.5 | -113 | 23 (3.3) |
- Garoppolo has suited up for seven games in 2022, and he’s delivered 1,691 passing yards, 11 touchdowns, four interceptions and a 66.7% completion percentage.
- When he’s not moving the ball through the air, Garoppolo has rushed for 23 yards (3.3 yards per game) and one touchdown in seven games.
- Garoppolo has hit the over on passing yards prop bets in four of six opportunities this year (66.7%).
- Garoppolo has a passing touchdown in all seven games this year, with multiple passing TDs in four of them.

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Chargers Player Props
Austin Ekeler Prop Bets
Over/Under | Over Payout | 2022 Total (Per Game) | |
---|---|---|---|
Rush Yds | 45.5 | -114 | 427 (53.4) |
Rec. Yds | 41.5 | -115 | 381 (47.6) |
- On the ground, Ekeler has six touchdowns and 427 yards (53.4 per game).
- Ekeler also has 60 catches for 381 yards and four TDs.
- Ekeler hit his rushing yards over twice in eight games played this season.
- Ekeler has a rushing touchdown in five of eight games this season, including multiple rushing TDs once.

Justin Herbert Prop Bets
Over/Under | Over Payout | 2022 Total (Per Game) | |
---|---|---|---|
Pass Yds | 252.5 | -108 | 2254 (281.8) |
Pass TDs | 1.5 | +106 | 13 (1.6) |
Rush Yds | 6.5 | -111 | 51 (6.4) |
- Herbert has thrown for 2,254 yards (281.8 per game), completing 66.4% of his throws, with 13 touchdowns and five interceptions in eight games.
- Herbert has hit the over on his passing yard totals in three games this season (37.5% of total opportunities).
- In seven of eight games this year, Herbert has thrown a touchdown pass — and four of those games included multiple TD passes.

How to Bet on 49ers vs. Chargers Player Props
You can bet on NFL player props from the 49ers vs. Chargers matchup at every legal online sportsbook. For more NFL odds, including game moneylines, spreads, and over/under totals, check out the latest NFL lines as well as our guide to the best NFL betting sites.
And if you wanted to check out how much you could win on a $10 bet if you parlayed today’s 49ers vs. Chargers player props, don’t forget to check out our free parlay calculator.
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