49ers Cardinals Player Props: Best Player Prop Bets for 49ers vs. Cardinals – November 21, 2022

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Estadio Azteca is the venue where the San Francisco 49ers (5-4) will match up against the Arizona Cardinals (4-6) on Monday, November 21, 2022.

Defensively, the 49ers have been a top-five unit, ranking best by giving up only 280.6 yards per game. They rank ninth on offense (360 yards per game). From an offensive standpoint, the Cardinals are accumulating 333.7 total yards per game (20th-ranked). They rank 23rd in the NFL defensively (357.6 total yards allowed per game).

Check out player props for the 49ers’ and Cardinals’ best players in this contest.

49ers Player Props

Christian McCaffrey Prop Bets

Over/Under Over Payout 2022 Total (Per Game)
Rush Yds 62.5 -106 563 (62.6)
Rec. Yds 35.5 -129 395 (43.9)
  • In nine games for the 49ers, McCaffrey has run for 563 rushing yards and four touchdowns while averaging 4.5 yards per carry.
  • In addition to the stats he’s generated on the ground, McCaffrey has 47 catches (on 59 targets) for 395 yards and two touchdowns.
  • So far this season, McCaffrey has hit the over seven times on his rushing yards prop bet (in 11 opportunities).
  • McCaffrey has rushed for a score in four of his games this season but has yet to score more than once in a single contest.


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Jimmy Garoppolo Prop Bets

Over/Under Over Payout 2022 Total (Per Game)
Pass Yds 251.5 -113 1931 (241.4)
Pass TDs 1.5 -128 11 (1.4)
Rush Yds 1.5 -128 26 (3.3)
  • Garoppolo has played eight games in 2022, and he’s tallied 1,931 passing yards, 11 touchdowns, four interceptions and a 66.8% completion percentage.
  • As a runner, Garoppolo has scampered for 26 yards (1.4 YPC) and two touchdowns.
  • Garoppolo has exceeded his passing yards prop bet total in four games this season, or 57.1% of games with a prop available.
  • Garoppolo has thrown for a touchdown seven times this year in eight games played, including multiple TD passes four times.
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Cardinals Player Props

James Conner Prop Bets

Over/Under Over Payout 2022 Total (Per Game)
Rush Yds 51.5 -122 314 (44.9)
Rec. Yds 20.5 -111 139 (19.9)
  • Conner has rushed for 314 yards (44.9 per game) and three touchdowns in seven games.
  • In the passing game, Conner has scored zero touchdowns, with 22 catches for 139 yards.
  • Conner has hit the rushing yards over in four of 10 opportunities (40.0%).
  • Conner has a rushing touchdown in two games this year, including multiple rushing TDs once.
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DeAndre Hopkins Prop Bets

Over/Under Over Payout 2022 Total (Per Game)
Rec. Yds 74.5 -116 396 (99)
  • Hopkins has 36 receptions for 396 yards (99 per game) and two touchdowns in four games.
  • In three of his four games (75.0%), Hopkins has hit the over on receiving yards prop bets.
  • Hopkins has had a receiving touchdown in two of four games this year, but has not scored multiple receiving TDs in a game.
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How to Bet on 49ers vs. Cardinals Player Props

You can bet on NFL player props from the 49ers vs. Cardinals matchup at every legal online sportsbook. For more NFL odds, including game moneylines, spreads, and over/under totals, check out the latest NFL lines as well as our guide to the best NFL betting sites.

And if you wanted to check out how much you could win on a $10 bet if you parlayed today’s 49ers vs. Cardinals player props, don’t forget to check out our free parlay calculator.

Not sure what a parlay is? Or even how to bet on football? Check out our complete guide to sports betting.


Brian Twining

Sports, of all kind, have been a huge part of my life and daily routine for as long as I can remember. My favorite sports to watch are College Basketball, College Football, the NFL, MLB, Nascar, & the FIFA World Cup. My favorite sports to bet on are the NFL, Nascar, College Hoops, and College Football.

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