Saints vs Panthers Prediction: Week 3 Picks, Live Odds & Start Time – September 2022

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Two NFC South rivals clash on Sunday, September 25, 2022 at Bank of America Stadium when the New Orleans Saints (1-1) and the Carolina Panthers (0-2) meet.

Saints vs. Panthers Odds

Point Spread

The spread for this matchup is set at 2.5 points, with sportsbooks listing the Saints as the favorites.


As for the moneyline, the Saints have -135 odds to pick up the win, while the Panthers are listed at +115 to claim victory.


Finally, the total for the game is set at 41 points.

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Game Info

How to Watch Saints vs. Panthers Live?

  • Game Day: Sunday, September 25, 2022
  • Game Time: 1:00 PM ET
  • TV Channel: FOX
  • Location: Charlotte, North Carolina
  • Stadium: Bank of America Stadium

Betting Preview


The Saints are totaling 346.5 yards per game on offense this season (17th in NFL), and they are allowing 338.0 yards per game (17th) on defense. From an offensive standpoint, the Saints rank 19th in the NFL with 18.5 points per game. Meanwhile, they rank 21st in points allowed (338.0 points allowed per contest). The Saints are putting up 220.0 passing yards per game on offense this season (18th in NFL), and they are giving up 201.5 passing yards per game (11th) on the defensive side of the ball. The Saints are putting up 126.5 rushing yards per game on offense (ninth in the NFL), and they rank 22nd defensively with 136.5 rushing yards allowed per game. The Saints are averaging a 30.8% third-down percentage on offense (25th in the NFL), and they rank eighth on the other side of the ball with a 33.3% third-down percentage allowed. The Saints rank ninth in offensive yards per play (5.6) and ninth in yards per play allowed (5.0) this season. The Saints have forced three total turnovers (10th in NFL) this season and have turned it over six times (31st in NFL) for a turnover margin of -3, 26th-ranked in the NFL.


The Panthers have been sputtering offensively, ranking fourth-worst with 268.0 total yards per game. They have been more productive on the other side of the ball, giving up 310.0 total yards per contest (ninth-ranked). The Panthers are putting up 20.0 points per game on offense this season (15th-ranked). Meanwhile, they are surrendering 22.5 points per contest (18th-ranked) on defense. While the Panthers’ pass offense has had trouble moving the chains, ranking third-worst with 168.0 passing yards per game, their defense ranks third-best with only 150.0 passing yards allowed per contest. The Panthers have been struggling against the run, ranking fourth-worst with 160.0 rushing yards surrendered per game. They have been more effective on the other side of the ball, regstering 100.0 rushing yards per contest (20th-ranked). The Panthers’ offense has been struggling on third down, ranking fourth-worst in the NFL with a 26.1% third-down conversion percentage. They have been more effective defensively, giving up a 38.9% third-down rate (18th-ranked). The Panthers have been excelling on defense in terms of yards per play, giving up only 4.3 (fourth-best). On offense, they rank 20th in the NFL by posting 5.2 yards per play. The Panthers have produced zero forced turnovers (32nd in NFL) and committed three turnovers (16th in NFL) this season for a -3 turnover margin that ranks 26th in the NFL.

Saints vs. Panthers Injury Report


Saints: CB Alontae Taylor: Out (Knee), QB Jameis Winston: Questionable (Back), OT Ryan Ramczyk: Questionable (Elbow), TE Taysom Hill: Questionable (Rib), CB Paulson Adebo: Questionable (Ankle), FB Marcus Maye: Questionable (Rib), RB Alvin Kamara: Questionable (Ribs)


Panthers: CB Stantley Thomas-Oliver III: Questionable (Achilles), QB Matt Corral: Out (Ankle), DT Bravvion Roy: Out (Hamstring), CB Donte Jackson: Questionable (Hamstring)

Saints vs. Panthers Betting Analysis

Saints Betting Insights

The Saints have not won a game against the spread this season (0-2-0). The Saints have yet to cover a spread when they are at least 2.5-point favorites (0-1). Saints games have gone over the total once this season. The Saints finished with a 5-3 record in games they were listed as the moneyline favorite last season (winning 62.5% of those games). The Saints finished 5-3 last year (winning 62.5% of their games) when they played as a moneyline favorite of -135 or shorter.

Panthers Betting Insights

The Panthers have not covered the spread in any matchup this year (0-2-0). This season, Panthers games have hit the over once. The Panthers will play as the underdog for the first time this season. The Panthers have not entered a game this season as a bigger underdog on the moneyline than the +115 odds on them winning this game.

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Saints vs. Panthers Against The Spread & Betting Records


Overall Home Away
Point Total AVG 43.8 43.5 44.0
Implied Total AVG 24.0 23.0 25.0
ATS Record 0-2-0 0-1-0 0-1-0
Over/Under Record 1-1-0 0-1-0 1-0-0
Moneyline Favorite Record 1-0 0-0 1-0
Moneyline Underdog Record 0-1 0-1 0-0


Overall Home Away
Point Total AVG 42.8 42.0 43.5
Implied Total AVG 22.5 22.0 23.0
ATS Record 0-2-0 0-1-0 0-1-0
Over/Under Record 1-1-0 1-0-0 0-1-0
Moneyline Favorite Record 0-2 0-1 0-1
Moneyline Underdog Record 0-0 0-0 0-0

Players to Watch


  • Michael Thomas has brought down 11 passes on 17 targets for 122 total yards and three touchdowns. He is averaging 5.5 catches and 61.0 yards per game over two games played.
  • Jameis Winston has 505 passing yards, three touchdowns and three interceptions this year. He has completed 64.9% of his attempts, averaging 252.5 yards per game and 6.8 per attempt.
  • Taysom Hill has no receiving TDs yet this season, but has one catches for 2 yards on one targets, while averaging 0.5 catches and 1.0 yards per game.
  • Jarvis Landry averages 5.5 receptions and 69.5 yards per game, and has 139 total receiving yards and 11 catches. He’s gotten 14 total targets, but has not caught a touchdown pass.
  • On defense for the Saints, Pete Werner has racked up 20 tackles in 2022.
  • Marcus Maye has 13 tackles so far this season. He’s second on the Saints in tackles.
  • Shy Tuttle has recorded 11 tackles and 0.5 sacks so far this year. He’s fourth on the Saints in tackles.
  • This season, Bradley Roby has 10 tackles.


  • Baker Mayfield is averaging 6.8 passing yards per attempt (16th in the NFL) and 190.0 yards per game this year, completing 53.6% of his passes on the way to 380 total yards, two touchdowns and one interception through two games.
  • Mayfield has also rushed for one touchdown and 41 yards (second on the Panthers).
  • Christian McCaffrey averages 67.5 rushing yards per game over two games (135 total yards), while scoring one rushing touchdown.
  • McCaffrey also has eight catches for 50 yards (fourth on the Panthers). He has been targeted nine times and averages 25.0 yards per game.
  • So far this season, Robby Anderson has caught eight passes for 134 receiving yards with one touchdown through the air. He has been targeted 13 total times and is averaging 4.0 receptions per game over two games played.
  • D.J. Moore has 86 receiving yards and one touchdown from six receptions after getting 12 targets.
  • Brian Burns’ 2022 effort includes 12 tackles, 2.0 TFL, and 2.0 sacks through two games. He is fourth on the Panthers in tackles.
  • Frankie Luvu has totaled 4.0 TFL and 16 tackles through two games.
  • Xavier Woods has 20 tackles in the 2022 campaign.
  • Shaq Thompson has 16 tackles.

Saints vs. Panthers Predictions and Pick

Our prediction to win this contest is the Saints, and we predict that Saints will cover the spread (Saints -2.5). Finally, we see the scoring in this one going over the posted total of 41 points.

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How to Bet on Saints vs. Panthers

You can bet on Saints vs. Panthers at every legal online sportsbook. For more NFL odds, including moneylines, spreads, over/under totals as well as NFL prop odds, check out the latest NFL lines as well as our guide to the best NFL betting sites.

And if you wanted to check out how much you could win on a $10 bet if you parlayed today’s Saints vs. Panthers picks, don’t forget to check out our free parlay calculator.

Not sure what a parlay is? Or even how to bet on football? Check out our complete guide to sports betting.


Luis Escalante

Luis has been a regular contributor to 4for4 since 2014 and is currently the Director of Strategy at Betsperts Group. Luis comes from an analytics background, leveraging his data skills with multiple years of experience in NFL, fantasy football, daily fantasy sports, and betting.

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