Rams vs Chiefs Prediction: Odds, Picks & Betting Preview Week 12 – November 27, 2022

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The Los Angeles Rams (3-7) will have their hearts set on flipping the script on their four-game losing streak when they collide with the Kansas City Chiefs (8-2) at Arrowhead Stadium on Sunday, November 27, 2022.

Chiefs vs. Rams Odds

Point Spread

The spread for this matchup is set at 15.5 points, with bookmakers listing the Chiefs as the favorites.


As for the moneyline, the Chiefs have -1150 odds to pick up the win, while the Rams are listed at +750 to claim victory.


Finally, the over/under for the game is set at 41.5 points.

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Game Info

How to Watch Chiefs vs. Rams Live?

  • Game Day: Sunday, November 27, 2022
  • Game Time: 4:25 PM ET
  • TV Channel: FOX
  • Location: Kansas City, Missouri
  • Stadium: Arrowhead Stadium

Betting Preview


The Chiefs rank 18th in total defense this season (349.2 yards allowed per game), but they’ve been shining on the offensive side of the ball, ranking best in the NFL with 429.3 total yards per game. On offense, the Chiefs have been a top-five unit, ranking best in the NFL by putting up 30.0 points per game. They rank 19th on defense (23.3 points allowed per game).

The Chiefs rank 26th in pass defense this year (248.6 passing yards allowed per game), but they’ve been thriving on the other side of the ball, ranking best in the NFL with 314.7 passing yards per game. The Chiefs rank 17th in rushing yards this year (114.6 rushing yards per game), but they’ve been shining on the other side of the ball, ranking fifth-best in the NFL with 100.6 rushing yards allowed per game.

The Chiefs have the 11th-ranked defense this year in terms of third-down efficiency (38.8% third-down percentage allowed), and they’ve been more effective on offense, ranking best with a 51.7% third-down percentage. The Chiefs rank 16th in yards per play allowed this year (5.5), but they’ve been playing really well on the offensive side of the ball, ranking best in the NFL with 6.5 yards per play. The Chiefs rank 26th in the NFL with a -3 turnover margin after forcing 10 turnovers (24th in the NFL) while committing 13 (14th in the NFL).

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The Rams have not been getting things done on offense, ranking third-worst with 288.0 total yards per game. They have been more productive on defense, giving up 312.0 total yards per contest (10th-ranked). The Rams rank fourth-worst in points per game (16.8), but they’ve been more effective defensively, ranking 17th in the NFL with 22.7 points allowed per contest.

In terms of passing, the Rams rank 22nd in the NFL (211.9 passing yards per game) and 17th on defense (216.7 passing yards allowed per game). While the Rams’ run offense has been stuck in neutral, ranking second-worst with 76.1 rushing yards per game, their defense ranks fourth-best with only 95.3 rushing yards conceded per contest.

The Rams rank 16th in the NFL with a 40.6% third-down conversion percentage on offense, and 18th with a 40.5% third-down percentage allowed on the defensive side of the ball. The Rams rank worst in yards per play (4.7), but they’ve been better defensively, ranking 12th in the NFL with 5.3 yards conceded per play. The Rams have not done well in terms of turnovers, as the team’s turnover margin of -7 is third-worst in the NFL.

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Chiefs vs. Rams Injury Report


Player Pos. Injury Status
Clyde Edwards-Helaire RB Ankle Out
Kadarius Toney WR Hamstring Out
Chris Lammons CB Concussion Questionable
Jordan Franks TE Undisclosed Out


Player Pos. Injury Status
Matthew Stafford QB Head Out
Travin Howard ILB Hip Out
Ty Nsekhe OT Ankle Questionable
Brian Allen C Thumb Out
Allen Robinson II WR Ankle Questionable
Tyler Higbee TE Knee Questionable
Matt Skura C Knee Questionable
A’Shawn Robinson DT Knee Out

Chiefs vs. Rams Betting Analysis

Chiefs Betting Insights

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The Chiefs have covered the spread four times this season (4-6-0).

Games involving the Chiefs have hit the over five times this season. The Chiefs went 12-5 in games they were listed as the moneyline favorite last season (winning 70.6% of those games).

The Chiefs did not play a game last season with moneyline odds of -1150 or shorter.

Rams Betting Insights

The Rams have put together a record of 2-7-1 against the spread this season.

This year, Rams games have hit the over four times. The Rams have been listed as the underdog four times this season and have failed to win any of those games.

The Rams have not entered a game this season as a bigger underdog on the moneyline than the +750 odds on them winning this game.

Chiefs vs. Rams Against The Spread & Betting Records


Overall Home Away
Point Total AVG 50.8 50.9 50.6
Implied Total AVG 28.3 29.2 27.4
ATS Record 4-6-0 1-4-0 3-2-0
Over/Under Record 5-5-0 1-4-0 4-1-0
Moneyline Favorite Record 7-1 4-0 3-1
Moneyline Underdog Record 1-1 0-1 1-0


Overall Home Away
Point Total AVG 43.3 43.3 43.1
Implied Total AVG 23.8 24.3 23.0
ATS Record 2-7-1 1-5-0 1-2-1
Over/Under Record 4-6-0 3-3-0 1-3-0
Moneyline Favorite Record 3-3 2-3 1-0
Moneyline Underdog Record 0-4 0-1 0-3

Players to Watch


  • Patrick Mahomes II ranks first in the NFL with 3,265 passing yards through 10 games this year, averaging 326.5 per game with a 66.3% completion percentage and 28 touchdowns (first in the NFL) against seven interceptions.
  • In addition to his passing statistics, Mahomes has 238 rushing yards (third on the Chiefs), with one rushing touchdown.
  • Travis Kelce has caught 69 passes (fifth in the NFL) on 94 targets for 855 total yards (seventh in the NFL) and 11 touchdowns. He is averaging 6.9 catches and 85.5 yards per game through 10 games.
  • In nine games played, JuJu Smith-Schuster is averaging 68.3 yards and 5.1 receptions per game on the way to 615 receiving yards and 46 catches. He’s been targeted 64 times, and has two receiving touchdowns.
  • Marquez Valdes-Scantling has 27 catches for 459 yards and one touchdown. He’s been targeted 47 times in the passing game, and averages 2.7 receptions and 45.9 yards through 10 games played.
  • On the defensive side, Nick Bolton has 2.0 sacks to go with 7.0 TFL, 93 tackles, and one interception in 2022.
  • L’Jarius Sneed has 69 tackles, 2.0 TFL, and 3.5 sacks so far this season.
  • This season, Chris Jones has put up 9.0 sacks (fourth in the NFL) to go with his 9.0 TFL and 22 tackles.
  • Willie Gay Jr. has 2.5 sacks (fifth on the Chiefs) to go with 5.0 TFL and 47 tackles on the year.


  • Ben Skowronek has put up 249 receiving yards on 27 receptions, while being targeted 43 times this season.
  • Cam Akers has 237 rushing yards (leading the Rams) and one rushing touchdown, while averaging 29.6 yards per game and 3.1 per attempt (62nd in the NFL).
  • So far this season, Tutu Atwell has caught two passes for 116 receiving yards with one touchdown in the passing game. He has been targeted five total times and is averaging 0.3 receptions per game in six games played.
  • Van Jefferson has 68 receiving yards and one touchdown from six receptions after getting 13 targets.
  • Bobby Wagner has amassed 3.0 sacks (third on the Rams) to go with 3.0 TFL and 84 tackles over 10 games so far in 2022.
  • Aaron Donald has 46 tackles, 9.0 TFL, 5.0 sacks, and two passes defended.
  • In the 2022 campaign, Jalen Ramsey has 47 tackles, 3.0 TFL, 2.0 sacks, and one interception in 10 games.
  • Leonard Floyd’s stats include 41 tackles, 6.0 TFL, and 5.0 sacks in 10 games

Chiefs vs. Rams Predictions and Pick

Our pick to win this contest is the Chiefs, and we project that Chiefs will cover the spread (Chiefs -15.5). Finally, we see the scoring in this one going over the posted total of 41.5 points.

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How to Bet on Chiefs vs. Rams

You can bet on Chiefs vs. Rams at every legal online sportsbook. For more NFL odds, including moneylines, spreads, over/under totals as well as NFL prop odds, check out the latest NFL lines as well as our guide to the best NFL betting sites.

And if you wanted to check out how much you could win on a $10 bet if you parlayed today’s Chiefs vs. Rams picks, don’t forget to check out our free parlay calculator.

Not sure what a parlay is? Or even how to bet on football? Check out our complete guide to sports betting.


Andy Molitor

Andy has been involved in sports betting on and off his entire adult life and has been creating content surrounding it for the past five years. While the NFL is his first love, he also bets hundreds of college basketball games every winter and loves sweating golf DFS during the football offseason.

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