49ers vs Rams Prediction: Week 4 Picks, Live Odds & Start Time – October 2022

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The San Francisco 49ers (1-2) and the Los Angeles Rams (2-1) — two NFC West combatants — play on Monday, October 3, 2022 at Levi’s Stadium.

49ers vs. Rams Odds

Point Spread

The spread for this matchup is set at 1.5 points, with bookmakers listing the 49ers as the favorites.


As for the moneyline, the 49ers have -125 odds to pick up the win, while the Rams are listed at +105 to claim victory.


Finally, the total for the game is set at 42.5 points.

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Game Info

How to Watch 49ers vs. Rams Live?

  • Game Day: Monday, October 3, 2022
  • Game Time: 8:15 PM ET
  • TV Channel: ESPN
  • Location: Santa Clara, California
  • Stadium: Levi’s Stadium

Betting Preview


The 49ers rank 24th in total offense this season (323.7 yards per game), but they’ve been thriving on defense, ranking second-best in the NFL with 227.0 yards allowed per game. The 49ers own the third-best defense this season in terms of points allowed (12.3 points allowed per game), but they rank fifth-worst on the offensive side of the ball (15.7 points per game). While the 49ers rank fourth-worst in the NFL in passing offense with 172.7 passing yards per game, it’s been a different situation on the other side of the ball, as they rank best (148.3 passing yards per game allowed). On the defensive side of the ball, the 49ers have been a top-five unit in terms of rushing yards, ranking fourth-best by surrendering only 78.7 per game. They rank sixth on offense (151.0 rushing yards per game). Offensively, the 49ers rank 20th in the NFL with a 35.7% third-down conversion rate. Meanwhile, they rank 10th in third-down conversion rate allowed (32.5%). The 49ers are gaining 5.1 yards per play on offense (21st in the league), while featuring the best yards per play on defense in the NFL (3.9) this season. The 49ers have forced four total turnovers (12th in NFL) this season and have turned it over five times (19th in NFL) for a turnover margin of -1, 21st-ranked in the NFL.


The Rams are compiling 306.3 total yards per contest on offense this season (25th-ranked). Meanwhile, they are surrendering 346.3 total yards per game (17th-ranked). In terms of points scored the Rams rank 15th in the NFL (20.3 points per game), and they are 20th on defense (23.3 points allowed per game). The Rams are putting up 234.0 passing yards per contest on offense this season (17th-ranked). Meanwhile, they are giving up 252.7 passing yards per contest (23rd-ranked) on defense. The Rams’ rushing offense has been a bottom-five unit this season, generating 72.3 rushing yards per game, which ranks third-worst in the NFL. Defensively, they rank 10th with 93.7 rushing yards surrendered per contest. The Rams’ third-down offense has been leading the way for the team, as they rank fourth-best in the NFL with a 48.4% third-down conversion rate. In terms of defense, they are giving up a 47.4% third-down rate, which ranks 26th. From an offensive angle, the Rams are compiling 5.3 yards per play (18th-ranked). They rank 14th in the NFL on the other side of the ball (5.3 yards allowed per play). After forcing seven turnovers (fourth in NFL) and turning the ball over seven times (28th in NFL) this season, the Rams own the 13th-ranked turnover margin of 0.

49ers vs. Rams Injury Report


49ers: WR Danny Gray: Doubtful (Hip), DB Tarvarius Moore: Out (Hamstring), TE Ross Dwelley: Questionable (Rib), LB Azeez Al-Shaair: Out (Knee), DT Javon Kinlaw: Questionable (Knee), OT Trent Williams: Out (Ankle), FB Arik Armstead: Questionable (Foot)


Rams: OG David Edwards: Out (Illness), DB David Long Jr.: Out (Groin), C Brian Allen: Out (Knee), DB Decobie Durant: Out (Hamstring)

49ers vs. Rams Betting Analysis

49ers Betting Insights

The 49ers have covered the spread one time this season (1-2-0). The 49ers have an ATS record of 1-2 when playing as at least 1.5-point favorites. 49ers games have yet to go over the total once this season. The 49ers won 57.1% of the games last season when they were the moneyline favorite (8-6). The 49ers had an 8-6 record last year (winning 57.1% of their games) when they played as a moneyline favorite of -125 or shorter.

Rams Betting Insights

The Rams have put together a record of 1-2-0 against the spread this year. The Rams have not covered the spread when they are at least 1.5-point underdogs (0-1). Games involving the Rams have hit the over once this year. The Rams lost the only game they’ve played as the underdog this season. The Rams have played as an underdog of +105 or more once this season and lost that game.

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49ers vs. Rams Against The Spread & Betting Records


Overall Home Away
Point Total AVG 41.0 39.5 41.8
Implied Total AVG 23.0 24.0 22.5
ATS Record 1-2-0 1-0-0 0-2-0
Over/Under Record 0-3-0 0-1-0 0-2-0
Moneyline Favorite Record 1-2 1-0 0-2
Moneyline Underdog Record 0-0 0-0 0-0


Overall Home Away
Point Total AVG 48.8 49.0 48.5
Implied Total AVG 27.0 27.5 26.0
ATS Record 1-2-0 0-2-0 1-0-0
Over/Under Record 1-2-0 1-1-0 0-1-0
Moneyline Favorite Record 2-0 1-0 1-0
Moneyline Underdog Record 0-1 0-1 0-0

Players to Watch


  • Deebo Samuel‘s 131 receiving yards this season have come from 12 receptions on 22 targets. He’s averaging 4.0 catches and 43.7 yards per game, but has not yet scored a touchdown through the air.
  • Jimmy Garoppolo has 365 passing yards, two touchdowns and one interception this year. He has completed 62.0% of his attempts, averaging 182.5 yards per game and 7.3 per attempt.
  • He’s rushed for 5 yards (eighth on the 49ers) and added one touchdown on the ground, while averaging 2.5 rushing yards per game.
  • Jeff Wilson Jr. has 181 rushing yards without a rushing TD (60.3 yards per game through three games).
  • Wilson also has seven receptions, 58 yards and zero TDs in the passing game.
  • Brandon Aiyuk has 10 catches for 142 yards and one touchdown. He’s been targeted 18 times in the passing game, and averages 3.3 receptions and 47.3 yards in three games played.
  • On the defensive side, Nick Bosa has 4.0 sacks (second in the NFL) to go with 3.0 TFL and 11 tackles in 2022.
  • Talanoa Hufanga has intercepted one pass (10th in the NFL) and added 21 tackles, 2.0 TFL, and three passes defended.
  • Charvarius Ward has collected one interception (10th in the NFL) and added 17 tackles, 1.0 TFL, and three passes defended.
  • Dre Greenlaw has 1.0 TFL and 22 tackles on the season.


  • This year, Cooper Kupp has 28 receptions (second in the NFL) for 280 yards (eighth in the NFL) with three receiving touchdowns (second in the NFL). He has been targeted 35 times and averages 9.3 catches per game in three games played.
  • Through three games, Matthew Stafford has 761 passing yards, with four touchdowns against five interceptions and completing 72.5% of his passes.
  • Darrell Henderson is averaging 37.0 rushing yards per game this season (111 total yards), while scoring one rushing touchdown.
  • Tyler Higbee has been targeted 24 times, resulting in 16 catches for 171 yards and zero receiving touchdowns.
  • Bobby Wagner’s 2022 effort includes 23 tackles, 1.0 TFL, and 2.0 sacks in three games. He is second on the Rams in tackles.
  • Jalen Ramsey has 1.0 TFL, 16 tackles, and one interception.
  • Ernest Jones has 24 tackles and 1.0 TFL in the 2022 season. He leads the Rams in tackles.
  • Nick Scott has 17 tackles and one pass defended.

49ers vs. Rams Predictions and Pick

Our prediction to win this contest is the Rams, and we expect that Rams will cover the spread (49ers -1.5). Finally, we see the scoring in this one going under the posted total of 42.5 points.

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How to Bet on 49ers vs. Rams

You can bet on 49ers vs. Rams at every legal online sportsbook. For more NFL odds, including moneylines, spreads, over/under totals as well as NFL prop odds, check out the latest NFL lines as well as our guide to the best NFL betting sites.

And if you wanted to check out how much you could win on a $10 bet if you parlayed today’s 49ers vs. Rams picks, don’t forget to check out our free parlay calculator.

Not sure what a parlay is? Or even how to bet on football? Check out our complete guide to sports betting.


Luis Escalante

Luis has been a regular contributor to 4for4 since 2014 and is currently the Director of Strategy at Betsperts Group. Luis comes from an analytics background, leveraging his data skills with multiple years of experience in NFL, fantasy football, daily fantasy sports, and betting.

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