Patriots vs Steelers Prediction: Week 2 Picks, Live Odds & Start Time – September 18, 2022

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Acrisure Stadium is where the Pittsburgh Steelers (1-0) will square off against the New England Patriots (0-1) on Sunday, September 18, 2022.

Patriots vs. Steelers Odds

Point Spread

The spread for this matchup is set at 2.5 points, with bookmakers listing the Patriots as the favorites.


As for the moneyline, the Patriots have -135 odds to pick up the win, while the Steelers are listed at +115 to claim victory.


Finally, the over/under for the game is set at 40.5 points.

Game Info

How to Watch Patriots vs. Steelers Live?

  • Game Day: Sunday, September 18, 2022
  • Game Time: 1:00 PM ET
  • TV Channel: CBS
  • Location: Pittsburgh, Pennsylvania
  • Stadium: Acrisure Stadium

Betting Preview


  • The Patriots put an average of 27.2 points on the board last year, 3.8 more than the 23.4 the Steelers surrendered.
  • When New England put up more than 23.4 points last season, it went 8-3 against the spread and 9-2 overall.
  • The average number of yards the Patriots’ offense put up and the Steelers’ defense gave up last season was within 7.7 yards (353.4 compared to 361.1). The Patriots averaged 5.7 yards per play, while the Steelers gave up 5.5.
  • New England was 4-3 against the spread and 4-3 overall when the team piled up over 361.1 yards last season.
  • The Patriots averaged 126.5 yards on the ground last season, 19.6 yards fewer than the Steelers allowed to opposing rushing attacks (146.1).
  • New England had a 5-1 ATS record and a 5-1 overall record when the team ran for over 146.1 yards last year.


  • The Steelers put roughly the same amount of points on the board per game last year (20.2) as the Patriots conceded (17.8).
  • When Pittsburgh put up over 17.8 points last year, it was 6-3 against the spread and 7-2 overall.
  • The Steelers’ offense gained 315.4 yards per game last year, within 4.6 yards of the 310.8 the Patriots’ defense conceded. The Steelers picked up 4.8 yards per play and the Patriots gave up 5.1.
  • When Pittsburgh picked up over 310.8 yards last year, the team was 4-5 against the spread and 5-3 overall.
  • The Patriots’ defense surrendered an average of 123.7 yards to opposing running games last year. That is 30.6 more yards than the Steelers accumulated running the football (93.1).
  • Last year Pittsburgh had a 2-2 ATS record and a 2-1 overall record in games the team rushed for over 123.7 yards.

Patriots vs. Steelers Injury Report


Patriots: LB Raekwon McMillan: Questionable (Thumb), FB Trent Brown: Questionable (Toe), RB Pierre Strong Jr.: Questionable (Shoulder), DB Adrian Phillips: Questionable (Ribs), CB Joejuan Williams: Out (Shoulder), CB Shaun Wade: Questionable (Ankle), WR Ty Montgomery: Out (Ankle), FB Joshuah Bledsoe: Out (Knee)


Steelers: RB Jeremy McNichols: Out (Shoulder), LB T.J. Watt: Out (Pectoral), WR Anthony Miller: Out (Shoulder)

Patriots vs. Steelers Betting Analysis

Patriots Betting Insights

  • The Patriots covered the spread 10 times in 17 games last season.
  • The Patriots’ ATS record as 2.5-point favorites or greater was 7-4 last season.
  • New England won 66.7% of the games last season when it was favored on the moneyline (8-4).
  • When playing as a moneyline favorite with odds of -135 or shorter, New England had an 8-3 record (winning 72.7% of its games).
  • In 17 Patriots games last season, nine went over the total.

Steelers Betting Insights

  • The Steelers had eight wins in 17 games against the spread last season.
  • The Steelers had an ATS record of 5-4 as underdogs of 2.5 points or greater last season.
  • Pittsburgh was an underdog 10 times last season and won five of those games.
  • Pittsburgh had a record of 4-5, a 44.4% win rate, when it was set as an underdog of +115 or more by bookmakers last season.
  • There were six Steelers games (out of 17) that hit the over last season.

Patriots vs. Steelers Against The Spread & Betting Records


Overall Home Away
Point Total AVG 44.1 44.6 43.7
Implied Total AVG 24.8 25.2 24.3
ATS Record 10-7-0 5-4-0 5-3-0
Over/Under Record 9-8-0 6-3-0 3-5-0
Moneyline Favorite Record 8-4 4-3 4-1
Moneyline Underdog Record 2-3 0-2 2-1


Overall Home Away
Point Total AVG 43.6 42.6 44.6
Implied Total AVG 24.2 23.3 25.1
ATS Record 8-9-0 4-5-0 4-4-0
Over/Under Record 6-10-1 2-6-1 4-4-0
Moneyline Favorite Record 4-2-1 4-2-1 0-0
Moneyline Underdog Record 5-5 2-0 3-5

Players to Watch


  • In 17 games played last year, Mac Jones amassed 3,801 passing yards, while throwing 22 touchdowns against 13 interceptions and completing 67.6% of his attempts.
  • Damien Harris scored 15 rushing touchdowns, while totaling 929 rushing yards (4.6 per attempt and 61.9 per game).
  • In 17 games played last season, Kendrick Bourne had 55 catches (3.2 receptions per game on 4.1 targets per game) for 800 yards and five receiving touchdowns.
  • Hunter Henry had 603 receiving yards and nine touchdowns (ninth in the NFL) from 50 receptions on 75 targets.
  • Matthew Judon had 60 tackles, 14.0 TFL, 12.5 sacks, and one pass defended in 2021.
  • Ja’Whaun Bentley had 109 tackles, 5.0 TFL, and 1.0 sack.
  • Over the 2021 season, Adrian Phillips had 92 tackles, 3.0 TFL, and four interceptions over 17 games.
  • Kyle Dugger’s stat sheet included four interceptions as well as 92 tackles, 5.0 TFL, and five passes defended in 15 games


  • In 17 games last season, Najee Harris piled up 1,200 rushing yards and seven touchdowns while averaging 3.9 yards per carry.
  • Najee Harris made a difference in the receiving game too, grabbing 74 balls on 94 targets for 467 yards and three touchdowns.
  • In 16 games, Diontae Johnson was targeted 169 times, leading to 107 receptions, 1,161 yards and eight touchdowns.
  • Last year Chase Claypool caught 59 balls on 105 targets for 860 yards and two touchdowns.
  • Pat Freiermuth got 79 targets last season and converted them into 60 grabs (3.8 per game) for 497 yards and seven TDs.
  • Cameron Heyward helped carry the defense with 89 tackles, 15.0 TFL, 10.0 sacks, and one interception in 17 games.
  • On defense, Minkah Fitzpatrick totaled 1.0 TFL, 124 tackles, and two interceptions.
  • In 16 games, Alex Highsmith registered 74 tackles, 15.0 TFL, and 6.0 sacks.
  • Terrell Edmunds amassed 1.0 sack to go with 8.0 TFL, 89 tackles, and two interceptions in 17 games.

Patriots vs. Steelers Predictions and Pick

Our pick to win this game is the Patriots, and we expect that Patriots will cover the spread (Patriots -2.5). Finally, we see the scoring in this one going over the posted total of 40.5 points.

How to Bet on Patriots vs. Steelers

You can bet on Patriots vs. Steelers at every legal online sportsbook. For more NFL odds, including moneylines, spreads, over/under totals as well as NFL prop odds, check out the latest NFL lines as well as our guide to the best NFL betting sites.

And if you wanted to check out how much you could win on a $10 bet if you parlayed today’s Patriots vs. Steelers picks, don’t forget to check out our free parlay calculator.

Not sure what a parlay is? Or even how to bet on football? Check out our complete guide to sports betting.


Andy Molitor

Andy has been involved in sports betting on and off his entire adult life and has been creating content surrounding it for the past five years. While the NFL is his first love, he also bets hundreds of college basketball games every winter and loves sweating golf DFS during the football offseason.

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