Chargers vs Chiefs Prediction: Odds, Picks & Betting Preview Week 11 – November 20, 2022

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The Kansas City Chiefs (7-2), who have found victory in three consecutive games, enter into a matchup against the Los Angeles Chargers (5-4) on Sunday, November 20, 2022 at SoFi Stadium.

Chiefs vs. Chargers Odds

Point Spread

The spread for this matchup is set at 5.5 points, with bookmakers listing the Chiefs as the favorites.


As for the moneyline, the Chiefs have -230 odds to pick up the win, while the Chargers are listed at +195 to claim victory.


Finally, the over/under for the game is set at 52.5 points.

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Game Info

How to Watch Chiefs vs. Chargers Live?

  • Game Day: Sunday, November 20, 2022
  • Game Time: 8:20 PM ET
  • TV Channel: NBC
  • Location: Inglewood, California
  • Stadium: SoFi Stadium

Betting Preview


On the offensive side of the ball, the Chiefs have been a top-five unit, ranking second-best in the NFL by totaling 423.1 yards per game. They rank 16th on defense (347.4 yards allowed per game). On the offensive side of the ball, the Chiefs have been a top-five unit, ranking best in the NFL by compiling 30.0 points per game. They rank 19th on defense (22.9 points allowed per game).

The Chiefs rank 25th in pass defense this season (248.4 passing yards allowed per game), but they’ve been thriving on offense, ranking best in the NFL with 313.9 passing yards per game. On the defensive side of the ball, the Chiefs have been a top-five unit in terms of rushing yards, ranking fifth-best by surrendering just 99.0 per game. They rank 21st on offense (109.2 rushing yards per game).

The Chiefs rank eighth in third-down defense this season (36.5% third-down percentage allowed), but they’ve been playing really well on offense, ranking second-best in the NFL with a 51.9% third-down conversion rate. On offense, the Chiefs have been a top-five unit in terms of yards per play, ranking second-best in the NFL by totaling 6.4 yards per play. They rank 13th on defense (5.4 yards per play allowed). With eight forced turnovers (27th in NFL) against 12 turnovers committed (15th in NFL), the Chiefs (-4) own the 27th-ranked turnover margin in the NFL.


From an offensive perspective, the Chargers are putting up 350.2 total yards per contest (14th-ranked). They rank 21st in the NFL on the other side of the ball (356.1 total yards surrendered per game). The Chargers’ defense has been a bottom-five unit in scoring defense this season, allowing 25.3 points per game, which ranks fourth-worst in the NFL. Offensively, they rank 16th with 22.2 points per contest.

The Chargers’ pass offense has been thriving, posting 265.3 passing yards per contest (fifth-best) this season. On defense, they rank 13th by giving up 209.2 passing yards per game. In terms of rushing, this season has been hard for the Chargers on both offense and defense, as they are putting up only 84.9 rushing yards per game (third-worst) and surrendering 146.9 rushing yards per game (third-worst).

The Chargers rank 13th in the NFL with a 41.3% third-down conversion percentage on offense, and 25th with a 43.2% third-down percentage allowed on the defensive side of the ball. In terms of yards per play, the Chargers rank 22nd in the NFL (5.2) and 23rd on the other side of the ball (5.8 yards allowed per play). With 12 forced turnovers (15th in NFL) and 10 turnovers committed (eighth in NFL) this season, the Chargers rank ninth in the NFL with a turnover margin of +2.

Chiefs vs. Chargers Injury Report


Player Pos. Injury Status
Mecole Hardman WR Abdomen Out
Chris Lammons CB Concussion Out
JuJu Smith-Schuster WR Concussion Out


Player Pos. Injury Status
Gerald Everett TE Groin Questionable
Dustin Hopkins K Hamstring Doubtful
Keenan Allen WR Hamstring Questionable
Mike Williams WR Ankle Questionable

Chiefs vs. Chargers Betting Analysis

Chiefs Betting Insights

The Chiefs have covered the spread in a game four times this season (4-5-0). In games they have played as 5.5-point favorites or more, the Chiefs have an ATS record of 2-2.

Games involving the Chiefs have hit the over four times this season. The Chiefs went 12-5 in games they were favored on the moneyline last season (winning 70.6% of those games).

In games they played as a moneyline favorite with odds of -230 or shorter, the Chiefs went 9-2 (81.8%).

Chargers Betting Insights

The Chargers have covered the spread in a matchup five times this year (5-4-0). The Chargers are a perfect 1-0 ATS when playing as at least 5.5-point underdogs.

This season, Chargers games have hit the over four times. The Chargers have lost both games they’ve played as underdogs this season.

The Chargers have played as an underdog of +195 or more once this season and lost that game.

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Chiefs vs. Chargers Against The Spread & Betting Records


Overall Home Away
Point Total AVG 50.6 50.9 50.1
Implied Total AVG 28.2 29.2 27.0
ATS Record 4-5-0 1-4-0 3-1-0
Over/Under Record 4-5-0 1-4-0 3-1-0
Moneyline Favorite Record 6-1 4-0 2-1
Moneyline Underdog Record 1-1 0-1 1-0


Overall Home Away
Point Total AVG 48.3 48.6 48.1
Implied Total AVG 26.6 26.8 26.4
ATS Record 5-4-0 1-3-0 4-1-0
Over/Under Record 4-5-0 2-2-0 2-3-0
Moneyline Favorite Record 5-2 2-2 3-0
Moneyline Underdog Record 0-2 0-0 0-2

Players to Watch


  • Patrick Mahomes II has passed for 2,936 yards (first in the NFL), 25 touchdowns (first in the NFL) and seven interceptions this year. He is averaging 326.2 yards per game and 8.0 per attempt, while completing 66.9% of his passes.
  • He has also rushed for 215 yards (third on the Chiefs) and added one touchdown on the ground, while averaging 23.9 rushing yards per game.
  • Travis Kelce has 63 catches (sixth in the NFL) for 740 yards (seventh in the NFL) and eight TDs. In nine games, he is averaging 7.0 catches and 82.2 yards per game.
  • Clyde Edwards-Helaire‘s output on the ground this season includes 293 yards and three TDs. He’s averaging 32.6 yards per game and 4.2 per attempt (41st in the NFL).
  • Edwards-Helaire has 17 catches, 151 yards and three TDs through the air.
  • JuJu Smith-Schuster has 46 catches for 615 yards and two touchdowns. He’s been targeted 64 times in the air attack, and averages 5.1 receptions and 68.3 yards in nine games played.
  • On the defensive side for the Chiefs, Nick Bolton has put up 79 tackles, 7.0 TFL, and 2.0 sacks in 2022.
  • L’Jarius Sneed has 64 tackles, 1.0 TFL, 3.5 sacks, and four passes defended.
  • Chris Jones has totaled 17 tackles, 6.0 TFL, and 7.0 sacks this year.
  • This season, Carlos Dunlap has 23 tackles, 3.0 TFL, and 4.0 sacks.


  • Austin Ekeler averages 50.1 rushing yards per game this year (451 total yards), while scoring six rushing touchdowns.
  • On top of his impact in the run game, Ekeler has caught 67 passes (on 82 targets) for 420 yards (second on the Chargers), with four receiving touchdowns. He’s averaging 46.7 yards per game.
  • In nine games, Justin Herbert has 2,450 passing yards (seventh-best in the NFL), while throwing 14 touchdowns (ninth in the NFL) against six interceptions and completing 65.8% of his attempts.
  • Mike Williams has put up 495 receiving yards and three touchdowns on 37 receptions, while being targeted 59 times this season.
  • Gerald Everett has 364 receiving yards and two touchdowns from 34 receptions after getting 55 targets.
  • Drue Tranquill has intercepted one pass and also has 80 tackles, 4.0 TFL, 3.5 sacks, and two passes defended in 2022.
  • Derwin James has 3.0 sacks (third on the Chargers) to go with 4.0 TFL and 84 tackles.
  • Over the 2022 campaign, Khalil Mack has 30 tackles, 5.0 TFL, and 6.5 sacks through nine games.
  • Kenneth Murray has intercepted one pass to go with 40 tackles, 5.0 TFL, and one pass defended.

Chiefs vs. Chargers Predictions and Pick

Our pick to win this game is the Chiefs, and we project that Chiefs will cover the spread (Chiefs -5.5). Finally, we see the scoring in this one going under the posted total of 52.5 points.

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How to Bet on Chiefs vs. Chargers

You can bet on Chiefs vs. Chargers at every legal online sportsbook. For more NFL odds, including moneylines, spreads, over/under totals as well as NFL prop odds, check out the latest NFL lines as well as our guide to the best NFL betting sites.

And if you wanted to check out how much you could win on a $10 bet if you parlayed today’s Chiefs vs. Chargers picks, don’t forget to check out our free parlay calculator.

Not sure what a parlay is? Or even how to bet on football? Check out our complete guide to sports betting.


Brian Twining

Sports, of all kind, have been a huge part of my life and daily routine for as long as I can remember. My favorite sports to watch are College Basketball, College Football, the NFL, MLB, Nascar, & the FIFA World Cup. My favorite sports to bet on are the NFL, Nascar, College Hoops, and College Football.

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