Cardinals vs Raiders Prediction: Odds, Picks & Betting Preview Week 2 – September 18, 2022

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The Arizona Cardinals (0-1) visit Allegiant Stadium on Sunday, September 18, 2022 to go up against the Las Vegas Raiders (0-1).

Raiders vs. Cardinals Odds

Point Spread

The spread for this matchup is set at 5 points, with oddsmakers listing the Raiders as the favorites.


As for the moneyline, the Raiders have -215 odds to pick up the win, while the Cardinals are listed at +185 to claim victory.


Finally, the total for the game is set at 51.5 points.

Game Info

How to Watch Raiders vs. Cardinals Live?

  • Game Day: Sunday, September 18, 2022
  • Game Time: 4:25 PM ET
  • TV Channel: CBS
  • Location: Paradise, Nevada
  • Stadium: Allegiant Stadium

Betting Preview


  • The Raiders’ average points scored last year (22.0) and the Cardinals’ average points allowed (21.5) were within 0.5 points.
  • Las Vegas was 7-1 against the spread and 8-0 overall in games when it scored more than 21.5 points last season.
  • The Raiders’ offense averaged 363.8 yards per game last season, 34.6 more than the 329.2 the Cardinals’ defense allowed. The Raiders earned 5.7 yards per play, while the Cardinals allowed 5.4.
  • When Las Vegas piled up more than 329.2 yards last season, the team was 7-2 against the spread and 8-1 overall.
  • The Cardinals allowed opposing rushing attacks to average 114.8 yards per game last season, compared to the 95.1 yards the Raiders’ offense averaged on the ground.
  • When Las Vegas rushed for over 114.8 yards last year, it had a 4-2 ATS record and a 5-1 overall record.


  • The Cardinals’ average points scored last season (26.4) and the Raiders’ average points conceded (25.8) were within 0.6 points of each other.
  • Arizona was 7-2 against the spread and 8-1 overall in games when it recorded over 25.8 points last season.
  • The Raiders surrendered 337.2 yards per game last year, 36.4 less yards than the Cardinals generated (373.6). The Cardinals gained 5.6 yards per play, while the Raiders allowed 5.2.
  • In games that Arizona totaled more than 337.2 yards last year, the team was 8-4 against the spread and 9-3 overall.
  • The Raiders’ defense allowed an average of 114.3 yards to opposing running games last season. That is about the same as the rushing output per contest for the Cardinals (122.1).
  • Arizona had a 7-2 ATS record and a 7-2 overall record when the team rushed for over 114.3 yards last year.

Raiders vs. Cardinals Injury Report


Raiders: FB Trevon Moehrig: Out (Hip), C Andre James: Out (Head), LB Denzel Perryman: Out (Ankle), RB Brandon Bolden: Doubtful (Hamstring), WR D.J. Turner: Out (Ankle), CB Anthony Averett: Out (Thumb), LB Micah Kiser: Out (Knee), WR Dillon Stoner: Out (Undisclosed)


Cardinals: FB Jalen Thompson: Questionable (Toe), FB Rashaad Coward: Out (Undisclosed), WR Victor Bolden Jr.: Out (Undisclosed), CB Trayvon Mullen: Questionable (Toe), FB Justin Pugh: Questionable (Neck), DE J.J. Watt: Questionable (Calf), WR Andy Isabella: Out (Back), WR Rondale Moore: Out (Hamstring)

Raiders vs. Cardinals Betting Analysis

Raiders Betting Insights

  • The Raiders had eight wins in 17 games against the spread last year.
  • The Raiders didn’t have a win ATS (0-1) as a 5-point favorite or more last season.
  • Las Vegas won three of the six games it was favored on the moneyline last season (50%).
  • Las Vegas played as a moneyline favorite of -215 or shorter in only one game last season, which it lost.
  • Out of 17 Raiders games last season, eight went over the total.

Cardinals Betting Insights

  • The Cardinals had 10 wins in 17 games against the spread last season.
  • The Cardinals covered every time (2-0) as underdogs of 5 points or more last year.
  • Last season, Arizona won six out of the six games in which it was the underdog.
  • Arizona entered two games last season as the underdog by +185 or more and won each of those games.
  • There were eight Cardinals games (out of 17) that went over the total last year.

Raiders vs. Cardinals Against The Spread & Betting Records


Overall Home Away
Point Total AVG 47.6 48.1 47.2
Implied Total AVG 25.9 25.4 26.5
ATS Record 8-9-0 4-5-0 4-4-0
Over/Under Record 8-9-0 5-4-0 3-5-0
Moneyline Favorite Record 3-3 2-2 1-1
Moneyline Underdog Record 7-4 3-2 4-2


Overall Home Away
Point Total AVG 48.7 48.3 49.1
Implied Total AVG 27.6 27.5 27.8
ATS Record 10-7-0 2-6-0 8-1-0
Over/Under Record 8-9-0 4-4-0 4-5-0
Moneyline Favorite Record 5-6 3-5 2-1
Moneyline Underdog Record 6-0 0-0 6-0

Players to Watch


  • Derek Carr passed for 4,804 yards last year (to rank fifth in the NFL), with 23 touchdowns and 14 interceptions. He completed 68.4% of his attempts while averaging 282.6 yards per game and 7.7 per attempt.
  • Davante Adams had 123 catches (second in the NFL) for 1,553 yards (third in the NFL) and 11 receiving touchdowns (fifth in the NFL). He was targeted 169 times and averaged 7.7 receptions per game over 16 games played for the Packers.
  • Josh Jacobs rushed for nine touchdowns last year and totaled 872 rushing yards (58.1 per game and 4.0 per carry).
  • Jacobs’ offensive output included 54 receptions (3.6 per game) on 64 targets for 348 yards (23.2 per game), though he did not found the end zone through the air.
  • Hunter Renfrow had 103 catches (ninth in the NFL) for 1,038 yards and nine receiving touchdowns (ninth in the NFL). He averaged 6.1 yards per game over 17 games and was targeted 128 times.
  • In 2021, Denzel Perryman recorded 5.0 TFL and 154 tackles in 15 games.
  • Chandler Jones had 40 tackles, 12.0 TFL, and 10.5 sacks for the Cardinals.
  • Maxx Crosby had 8.0 sacks as well as 13.0 TFL and 55 tackles in the 2021 season.
  • Johnathan Abram registered 5.0 TFL, 116 tackles, and one interception in 14 games.


  • In 14 games last season, Kyler Murray threw for 3,787 yards (270.5 yards per game) while recording 24 touchdowns, 10 interceptions and a 69.2% completion percentage.
  • Murray also generated offense with his legs, rushing for 423 yards (4.8 YPC) and five touchdowns.
  • As a runner, James Conner picked up 752 yards on the ground with 15 touchdowns.
  • Conner had 37 receptions (2.5 per game) for 375 yards (25.0 per game) and three TDs.
  • Darrel Williams ran for 558 rushing yards (32.8 yards per game) and six touchdowns with the Chiefs last season, averaging 3.9 yards per carry.
  • As a pass-catcher, Williams caught 47 balls on 57 targets for 452 yards and two touchdowns.
  • Marquise Brown was targeted 145 times with the Ravens last year, leading to 91 catches, 1,008 yards and six touchdowns in 16 games.
  • Jalen Thompson hit the gridiron for 17 games, delivering 3.0 TFL, 121 tackles, and three interceptions.
  • On defense, Isaiah Simmons totaled 1.5 sacks to go with 4.0 TFL, 106 tackles, and one interception.
  • Budda Baker played in 17 games and posted three interceptions to go along with 97 tackles, 6.0 TFL, 2.0 sacks, and seven passes defended.
  • With 11.0 sacks to go along with 10.0 TFL and 48 tackles, Markus Golden made a big difference on D.

Raiders vs. Cardinals Predictions and Pick

Our pick to win this matchup is the Cardinals, and we predict that Cardinals will cover the spread (Raiders -5). Finally, we see the scoring in this one going under the posted total of 51.5 points.

How to Bet on Raiders vs. Cardinals

You can bet on Raiders vs. Cardinals at every legal online sportsbook. For more NFL odds, including moneylines, spreads, over/under totals as well as NFL prop odds, check out the latest NFL lines as well as our guide to the best NFL betting sites.

And if you wanted to check out how much you could win on a $10 bet if you parlayed today’s Raiders vs. Cardinals picks, don’t forget to check out our free parlay calculator.

Not sure what a parlay is? Or even how to bet on football? Check out our complete guide to sports betting.


Brian Twining

Sports, of all kind, have been a huge part of my life and daily routine for as long as I can remember. My favorite sports to watch are College Basketball, College Football, the NFL, MLB, Nascar, & the FIFA World Cup. My favorite sports to bet on are the NFL, Nascar, College Hoops, and College Football.

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