Saints vs Buccaneers Prediction: Odds, Picks & Betting Preview Week 2 – September 18, 2022

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On Sunday, September 18, 2022, the New Orleans Saints (1-0) host an NFC South bout against the Tampa Bay Buccaneers (1-0) at Caesars Superdome.

Buccaneers vs. Saints Odds

Point Spread

The spread for this matchup is set at 2.5 points, with sportsbooks listing the Buccaneers as the favorites.


As for the moneyline, the Buccaneers have -135 odds to pick up the win, while the Saints are listed at +115 to claim victory.


Finally, the total for the game is set at 44 points.

Game Info

How to Watch Buccaneers vs. Saints Live?

  • Game Day: Sunday, September 18, 2022
  • Game Time: 1:00 PM ET
  • TV Channel: FOX
  • Location: New Orleans, Louisiana
  • Stadium: Caesars Superdome

Betting Preview


  • The Buccaneers, on average, scored 10.4 more points (30.1) than the Saints allowed (19.7) last year.
  • When Tampa Bay put up over 19.7 points last year, it went 9-5 against the spread and 12-2 overall.
  • The Buccaneers’ offense averaged 405.9 yards per game last year, 87.7 more than the 318.2 the Saints’ defense allowed. The Buccaneers earned 6.1 yards per play, while the Saints allowed 5.1.
  • When Tampa Bay piled up more than 318.2 yards last season, the team was 9-6 against the spread and 13-2 overall.
  • The Buccaneers averaged 98.4 yards on the ground last year, just 4.9 yards more than the Saints allowed to opposing rushing attacks (93.5).
  • Last season Tampa Bay had a 6-3 ATS record and an 8-1 overall record in games the team ran for more than 93.5 yards.


  • The Saints put roughly the same amount of points on the board per game (21.4) as the Buccaneers conceded (20.8) last season.
  • When New Orleans scored more than 20.8 points last season, it was 7-3 against the spread and 6-4 overall.
  • The Saints’ offense gained 27.0 fewer yards per game than the Buccaneers’ defense conceded last year (304.5 to 331.5). The Saints earned 4.9 yards per play, while the Buccaneers gave up 5.2.
  • New Orleans was 5-3 against the spread and 4-4 overall when the team totaled more than 331.5 yards last year.
  • The Buccaneers’ defense surrendered an average of 92.5 yards to opposing running games last year. That is 24.6 fewer yards than the Saints averaged running the football (117.1).
  • When New Orleans rushed for over 92.5 yards last season it compiled a 6-5 ATS record and a 7-4 overall record.

Buccaneers vs. Saints Injury Report


Buccaneers: OT Tristan Wirfs: Questionable (Abdomen), WR Breshad Perriman: Questionable (Knee), WR Julio Jones: Questionable (Knee), WR Russell Gage: Questionable (Hamstring), RB Leonard Fournette: Questionable (Hamstring), WR Chris Godwin: Out (Hamstring), RB Kenjon Barner: Out (Groin), OT Donovan Smith: Doubtful (Elbow), WR Mike Evans: Questionable (Calf), CB Zyon McCollum: Doubtful (Hamstring)


Saints: WR Tre’Quan Smith: Questionable (Shoulder), RB Mark Ingram II: Questionable (Ankle), RB Alvin Kamara: Questionable (Ribs), CB Paulson Adebo: Out (Ankle), OT Ethan Greenidge: Out (Knee), RB Dwayne Washington: Questionable (Hamstring), CB Alontae Taylor: Questionable (Hip), QB Jameis Winston: Questionable (Back)

Buccaneers vs. Saints Betting Analysis

Buccaneers Betting Insights

  • Against the spread, the Buccaneers were 9-8-0 last year.
  • Against the spread, as 2.5-point favorites or more, the Buccaneers went 9-7 last year.
  • Tampa Bay went 13-4 in games it was favored on the moneyline last season (winning 76.5% of those games).
  • Tampa Bay had a 13-3 record last year (winning 81.2% of its games) when it played as a moneyline favorite of -135 or shorter.
  • The Buccaneers had nine of its 17 games go over the point total last season.

Saints Betting Insights

  • Saints posted a 9-8-0 record against the spread last season.
  • The Saints had an ATS record of 5-4 as underdogs of 2.5 points or greater last season.
  • New Orleans was an underdog nine times last season and won four of those games.
  • New Orleans had a record of 4-5 in games where oddsmakers had them as underdogs of at least +115 on the moneyline.
  • There were seven Saints games (out of 17) that went over the total last year.

Buccaneers vs. Saints Against The Spread & Betting Records


Overall Home Away
Point Total AVG 49.6 49.1 50.0
Implied Total AVG 29.4 30.0 28.9
ATS Record 9-8-0 6-2-0 3-6-0
Over/Under Record 9-8-0 5-3-0 4-5-0
Moneyline Favorite Record 13-4 7-1 6-3
Moneyline Underdog Record 0-0 0-0 0-0


Overall Home Away
Point Total AVG 43.3 43.4 43.2
Implied Total AVG 24.3 24.6 24.0
ATS Record 9-8-0 3-5-0 6-3-0
Over/Under Record 7-10-0 3-5-0 4-5-0
Moneyline Favorite Record 5-3 1-2 4-1
Moneyline Underdog Record 4-5 2-3 2-2

Players to Watch


  • Over the course of 17 games played last year, Tom Brady racked up 5,316 passing yards (leading the league), with 43 touchdowns (first in the NFL) against 12 interceptions and completing 67.5% of his passes.
  • On the ground, Brady added two rushing touchdowns and 81 rushing yards.
  • Mike Evans put together a 2021 campaign that included 74 catches for 1,035 yards and 14 receiving touchdowns (second in the NFL) over 16 games played. He was on the receiving end of 114 targets and averaged 4.6 receptions per game.
  • Leonard Fournette rushed for eight touchdowns last year and totaled 812 rushing yards (58.0 per game and 4.5 per carry).
  • Fournette helped in the receiving game, putting up 454 receiving yards (32.4 per game) on 69 catches (4.9 per game), while being targeted 84 times. He had two receiving touchdowns.
  • Chris Godwin had 1,103 receiving yards and five touchdowns from 98 receptions on 128 targets.
  • In 2021, Devin White amassed 3.5 sacks to go with 8.0 TFL and 128 tackles in 17 games.
  • Logan Ryan had 117 tackles, 2.0 TFL, 1.0 sack, and eight passes defended for the Giants.
  • Shaquil Barrett had 9.5 sacks as well as 9.0 TFL, 50 tackles, and one interception in the 2021 campaign.
  • Antoine Winfield Jr. had 2.0 sacks to go with 4.0 TFL, 88 tackles, and two interceptions in 13 games.


  • Alvin Kamara put up big numbers in the running game last year, rushing for 898 yards and four touchdowns in 13 games.
  • In addition to the stats he produced in the ground attack, Kamara had 47 catches (on 67 targets) for 439 yards and five touchdowns.
  • Taysom Hill was an asset, racking up 52 receiving yards and zero touchdowns on four catches.
  • Jameis Winston was an important part of the offense last year, tallying 1,170 passing yards with 14 passing touchdowns, three interceptions and a 59.0% completion percentage.
  • With 166 rushing yards (5.2 YPC) and one rushing touchdown, Winston generated offense on the ground in addition to the passing game.
  • As an important contributor in the offense, Marquez Callaway produced 698 receiving yards and six touchdowns on 46 receptions.
  • With 12.5 sacks to go with 13.0 TFL and 59 tackles in 16 games, Cameron Jordan was a significant contributor on defense.
  • Demario Davis accumulated 3.0 sacks to go along with 13.0 TFL and 105 tackles in 16 games.
  • In 16 games for the Chiefs last year, Tyrann Mathieu delivered 76 tackles, 2.0 TFL, 1.0 sack, and three interceptions.
  • Marshon Lattimore was a significant contributor on D last year, with three interceptions to go with 68 tackles and 19 passes defended.

Buccaneers vs. Saints Predictions and Pick

Our prediction to win this game is the Buccaneers, and we predict that Buccaneers will cover the spread (Buccaneers -2.5). Finally, we see the scoring in this one going over the posted total of 44 points.

How to Bet on Buccaneers vs. Saints

You can bet on Buccaneers vs. Saints at every legal online sportsbook. For more NFL odds, including moneylines, spreads, over/under totals as well as NFL prop odds, check out the latest NFL lines as well as our guide to the best NFL betting sites.

And if you wanted to check out how much you could win on a $10 bet if you parlayed today’s Buccaneers vs. Saints picks, don’t forget to check out our free parlay calculator.

Not sure what a parlay is? Or even how to bet on football? Check out our complete guide to sports betting.


Luis Escalante

Luis has been a regular contributor to 4for4 since 2014 and is currently the Director of Strategy at Betsperts Group. Luis comes from an analytics background, leveraging his data skills with multiple years of experience in NFL, fantasy football, daily fantasy sports, and betting.

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