Bills vs. Browns Prediction: Week 11 Odds, Picks & Moneyline – November 20, 2022

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Sunday, November 20, 2022 will see the Buffalo Bills (6-3) host the Cleveland Browns (3-6) at Highmark Stadium.

Bills vs. Browns Odds

Point Spread

The spread for this matchup is set at 7.5 points, with sportsbooks listing the Bills as the favorites.


As for the moneyline, the Bills have -320 odds to pick up the win, while the Browns are listed at +265 to claim victory.


Finally, the over/under for the game is set at 50 points.

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Game Info

How to Watch Bills vs. Browns Live?

  • Game Day: Sunday, November 20, 2022
  • Game Time: 1:00 PM ET
  • TV Channel: CBS
  • Location: Orchard Park, New York
  • Stadium: Highmark Stadium

Betting Preview


The Bills rank eighth in total defense this year (319.8 yards allowed per game), but they’ve been shining on the other side of the ball, ranking best in the NFL with 424.1 total yards per game. The Bills have been surging on both offense and defense, ranking second-best in scoring offense (27.8 points per game) and second-best in scoring defense (16.8 points allowed per game).

The Bills rank 14th in pass defense this year (210.2 passing yards allowed per game), but they’ve been thriving on offense, ranking second-best in the NFL with 294.2 passing yards per game. The Bills are totaling 129.9 rushing yards per game offensively this year (ninth in NFL), and they are allowing 109.6 rushing yards per game (seventh) on the other side of the ball.

On offense, the Bills have been a top-five unit in terms of third-down efficiency, ranking best in the NFL by averaging a 52.4% third-down percentage. They rank 15th on defense (40.4% third-down conversion rate allowed). The Bills rank eighth in yards per play allowed this year (5.2), but they’ve been shining on the other side of the ball, ranking best in the NFL with 6.5 yards per play. The Bills have forced 17 total turnovers (third in NFL) this season and have turned it over 18 times (30th in NFL) for a turnover margin of -1, 19th-ranked in the league.


The Browns’ defense ranks 18th in the NFL with 349.1 total yards allowed per game, but they’ve been carried by their offense, which ranks fifth-best by generating 375.9 total yards per game. The Browns’ defense has been bottom-five in scoring defense this season, conceding 26.4 points per game, which ranks second-worst in the NFL. On offense, they rank 10th with 24.1 points per contest.

From an offensive angle, the Browns are posting 217.1 passing yards per contest (20th-ranked). They rank 19th in the NFL defensively (218.0 passing yards allowed per game). The Browns’ run defense ranks 23rd in the NFL with 131.1 rushing yards surrendered per contest, but they’ve been lifted up by their offense, which ranks fifth-best by racking up 158.8 rushing yards per contest.

In terms of third-down efficiency, the Browns rank 13th in the NFL (41.3% third-down conversion rate) and 18th on the other side of the ball (41.3% third-down rate allowed). The Browns rank 11th in the NFL with 5.6 yards per play on offense, and they rank 23rd with 5.8 yards given up per play on the defensive side of the ball. The Browns have forced eight turnovers this season and have turned the ball over 13 times, resulting in a -5 turnover margin that is fourth-worst in the NFL.

Bills vs. Browns Injury Report


Player Pos. Injury Status
Jake Kumerow WR Ankle Out
Reggie Gilliam FB Illness Questionable
Kaiir Elam CB Ankle Questionable
Gregory Rousseau DE Ankle Out
Tremaine Edmunds LB Groin Out
Marquez Stevenson WR Foot Questionable
Tre’Davious White CB Knee Out


Player Pos. Injury Status
Perrion Winfrey DT Head Out
Michael Dunn OG Back Out
Greg Newsome II CB Head Out
David Njoku TE Ankle Questionable

Bills vs. Browns Betting Analysis

Bills Betting Insights

The Bills have put together a 4-5-0 record against the spread this season. The Bills are 2-2 ATS when playing as at least 7.5-point favorites.

Bills games have gone over the total twice this season. The Bills won nine of the 14 games they were the moneyline favorite last season (64.3%).

When they played as a moneyline favorite with odds of -320 or shorter, the Bills had a 7-1 record (winning 87.5% of their games).

Browns Betting Insights

The Browns are 5-4-0 against the spread this season.

This year, Browns games have hit the over six times. This season, the Browns have won two out of the five games in which they’ve been the underdog.

The Browns have not entered a game this season with longer moneyline odds than +265.

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Bills vs. Browns Against The Spread & Betting Records


Overall Home Away
Point Total AVG 49.3 46.6 51.4
Implied Total AVG 28.2 28.8 27.8
ATS Record 4-5-0 2-2-0 2-3-0
Over/Under Record 2-7-0 2-2-0 0-5-0
Moneyline Favorite Record 6-3 3-1 3-2
Moneyline Underdog Record 0-0 0-0 0-0


Overall Home Away
Point Total AVG 44.3 42.4 46.6
Implied Total AVG 23.9 23.0 25.0
ATS Record 5-4-0 3-2-0 2-2-0
Over/Under Record 6-2-1 4-0-1 2-2-0
Moneyline Favorite Record 1-3 1-2 0-1
Moneyline Underdog Record 2-3 1-1 1-2

Players to Watch


  • Josh Allen has passed for 2,733 yards (third in the NFL), 20 touchdowns (second in the NFL) and 10 interceptions this year. He averages 303.7 yards per game and 8.0 per attempt, while completing 64.5% of his attempts.
  • He has tacked on 476 rushing yards (52.9 per game) and four touchdowns on the ground.
  • Stefon Diggs‘ 985 receiving yards this season (third in the NFL) have come from 98 targets and 72 receptions (third in the NFL). He’s averaging 109.4 receiving yards and 8.0 catches per game, with seven receiving touchdowns (third in the NFL).
  • In the passing attack, Gabriel Davis, has contributed with 544 receiving yards and five touchdowns (ninth in the NFL) after hauling in 24 balls on 47 targets. Per game, he’s averaging 68.0 yards and 3.0 receptions in eight games.
  • Devin Singletary has run for 394 yards, averaging 43.8 yards per game and scoring two touchdowns.
  • He has added 28 catches (on 38 targets) for 207 receiving yards with one touchdown. He’s averaging 23.0 receiving yards and 3.1 receptions per game.
  • On defense for the Bills, Matt Milano has put up 43 tackles, 7.0 TFL, and two interceptions in 2022.
  • Tremaine Edmunds has 66 tackles, 4.0 TFL, and 1.0 sack this season. His tackle total leads the Bills.
  • This season, Damar Hamlin has put up 1.5 sacks (fifth on the Bills) in addition to his 4.0 TFL and 60 tackles.
  • So far this season, Von Miller has 18 tackles, 7.0 TFL, and 8.0 sacks.


  • Nick Chubb averages 100.4 rushing yards per game this year (904 total yards to rank third in the NFL), while scoring 11 rushing touchdowns.
  • In eight games, Jacoby Brissett has 2,074 passing yards, while throwing eight touchdowns against five interceptions and completing 63.8% of his passes.
  • He has also added 182 rushing yards (third on the Browns), while scoring two touchdowns on the ground (averaging 22.8 yards per game and 4.8 per carry).
  • Amari Cooper has registered 585 receiving yards and five touchdowns (ninth in the NFL) on 42 receptions, while being targeted 69 times on the season.
  • Kareem Hunt has scored three touchdowns on the ground, while running for 314 total yards (3.8 per carry and 34.9 per game).
  • Hunt has also caught 20 passes for 127 yards (fifth on the Browns), with one receiving touchdown. He’s been targeted 24 times and averages 14.1 yards per game.
  • Myles Garrett has 22 tackles, 5.0 TFL, 7.5 sacks, and two passes defended in 2022.
  • Grant Delpit has 1.0 TFL, 55 tackles, and one interception over nine games.
  • John Johnson has 0.5 sacks as well as 3.0 TFL and 45 tackles in the 2022 campaign.
  • Martin Emerson has registered 1.0 sack to go with 1.0 TFL and 38 tackles through nine games.

Bills vs. Browns Predictions and Pick

Our pick to win this contest is the Bills, and we project that Bills will cover the spread (Bills -7.5). Finally, we see the scoring in this one going under the posted total of 50 points.

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How to Bet on Bills vs. Browns

You can bet on Bills vs. Browns at every legal online sportsbook. For more NFL odds, including moneylines, spreads, over/under totals as well as NFL prop odds, check out the latest NFL lines as well as our guide to the best NFL betting sites.

And if you wanted to check out how much you could win on a $10 bet if you parlayed today’s Bills vs. Browns picks, don’t forget to check out our free parlay calculator.

Not sure what a parlay is? Or even how to bet on football? Check out our complete guide to sports betting.


Luis Escalante

Luis has been a regular contributor to 4for4 since 2014 and is currently the Director of Strategy at Betsperts Group. Luis comes from an analytics background, leveraging his data skills with multiple years of experience in NFL, fantasy football, daily fantasy sports, and betting.

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