Saints vs 49ers Prediction: Odds, Picks & Betting Preview Week 12 – November 27, 2022

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On Sunday, November 27, 2022, the New Orleans Saints (4-7) visit a red-hot San Francisco 49ers (6-4) squad at Levi’s Stadium. The 49ers are looking to keep the good times rolling after winning three games in a row.

49ers vs. Saints Odds

Point Spread

The spread for this matchup is set at 9 points, with bookmakers listing the 49ers as the favorites.


As for the moneyline, the 49ers have -435 odds to pick up the win, while the Saints are listed at +350 to claim victory.


Finally, the over/under for the game is set at 43 points.

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Game Info

How to Watch 49ers vs. Saints Live?

  • Game Day: Sunday, November 27, 2022
  • Game Time: 4:25 PM ET
  • TV Channel: FOX
  • Location: Santa Clara, California
  • Stadium: Levi’s Stadium

Betting Preview


The 49ers own the eighth-ranked offense this season (362.7 yards per game), and they’ve been even better defensively, ranking best with only 283.9 yards allowed per game. Defensively, the 49ers have been a top-five unit, ranking third-best by surrendering only 17.3 points per game. They rank 12th on offense (23.6 points per game).

The 49ers are averaging 235.5 passing yards per game on offense, which ranks them ninth in the NFL. On the defensive side of the ball, they rank 11th, allowing 202.8 passing yards per contest. The 49ers have the 12th-ranked offense this year in terms of rushing yards (127.2 per game), and they’ve been more effective defensively, ranking best with only 81.1 rushing yards allowed per game.

The 49ers rank 23rd in third-down defense this year (42.0% third-down percentage allowed), but they’ve been thriving on the offensive side of the ball, ranking fifth-best in the NFL with a 46.4% third-down percentage. The 49ers have been firing on all cylinders in terms of yards per play this season, as they rank fourth-best in offensive yards per play (6.0) and second-best in yards per play allowed on defense (4.7). The 49ers own the 21st-ranked turnover margin in the NFL at -1, forcing 12 turnovers (20th in NFL) while turning it over 13 times (14th in NFL).

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From an offensive angle, the Saints are generating 355.2 total yards per game (10th-ranked). They rank 12th in the NFL on the other side of the ball (327.3 total yards allowed per game). The Saints are posting 22.6 points per game on offense this season (15th-ranked). Meanwhile, they are surrendering 24.3 points per game (25th-ranked) on defense.

In terms of passing, the Saints rank eighth in the NFL (237.3 passing yards per game) and seventh on the other side of the ball (195.2 passing yards allowed per contest). From an offensive standpoint, the Saints are generating 117.9 rushing yards per contest (15th-ranked). They rank 23rd in the NFL defensively (132.1 rushing yards allowed per game).

With a 40.3% third-down conversion rate on offense, the Saints rank 18th in the NFL. Defensively, they rank 11th, surrendering a 38.8% third-down rate. From an offensive standpoint, the Saints are generating 5.8 yards per play (sixth-ranked). They rank ninth in the NFL on the other side of the ball (5.2 yards surrendered per play). In terms of turnover margin, the Saints are the worst team in the NFL this season. Their margin comes in at -12, as they’ve forced seven turnovers and committed 19.

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49ers vs. Saints Injury Report


Player Pos. Injury Status
Deebo Samuel WR Hamstring Questionable


Player Pos. Injury Status
Mark Ingram II RB Knee Questionable
Payton Turner DE Ankle Out
Juantavius Gray DB Hamstring Out
Marshon Lattimore CB Abdomen Questionable
Pete Werner LB Ankle Out
Marcus Davenport DE Calf Questionable
Cameron Jordan DE Eye Questionable

49ers vs. Saints Betting Analysis

49ers Betting Insights

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The 49ers have covered the spread five times in 10 games with a set spread. The 49ers have a perfect 1-0 ATS record when playing as at least 9-point favorites.

49ers games have finished with a final combined score above the over/under four times this season. The 49ers finished with an 8-6 record in games they were listed as the moneyline favorite last season (winning 57.1% of those games).

The 49ers played as a moneyline favorite of -435 or shorter in only one game last season, which they won.

Saints Betting Insights

The Saints are 4-7-0 against the spread this year.

Saints games have finished with a final combined score above the over/under six times this year. The Saints have been underdogs in seven games this season and won one (14.3%) of those contests.

The Saints have not been a bigger underdog this season than the +350 moneyline set for this game.

49ers vs. Saints Against The Spread & Betting Records


Overall Home Away
Point Total AVG 43.0 43.9 42.3
Implied Total AVG 23.5 24.0 23.2
ATS Record 5-5-0 2-2-0 3-3-0
Over/Under Record 4-6-0 1-3-0 3-3-0
Moneyline Favorite Record 5-3 3-0 2-3
Moneyline Underdog Record 1-1 0-1 1-0


Overall Home Away
Point Total AVG 43.2 43.9 42.1
Implied Total AVG 22.7 23.1 22.0
ATS Record 4-7-0 4-3-0 0-4-0
Over/Under Record 6-5-0 4-3-0 2-2-0
Moneyline Favorite Record 3-1 2-0 1-1
Moneyline Underdog Record 1-6 1-4 0-2

Players to Watch


  • Jimmy Garoppolo has 2,159 passing yards, 15 touchdowns and four interceptions this year. He has completed 67.0% of his passes, averaging 239.9 yards per game and 8.1 per attempt.
  • He has tacked on 29 rushing yards (3.2 per game) and two touchdowns on the ground.
  • Christian McCaffrey‘s rushing output this season includes 602 yards and four TDs. He is averaging 60.2 yards per game and 4.6 per attempt (26th in the NFL).
  • He has caught 54 passes (on 66 targets) for 462 receiving yards with two touchdowns. He’s averaging 46.2 receiving yards and 5.4 catches per game.
  • Through 10 games played, Brandon Aiyuk is averaging 58.7 yards and 4.6 receptions per game on the way to 587 receiving yards and 46 catches. He’s been targeted 65 times, and has six receiving touchdowns (sixth in the NFL).
  • George Kittle has 424 receiving yards and four touchdowns with 33 catches on 47 targets. He’s averaging 4.1 receptions and 53.0 yards per game.
  • On defense for the 49ers, Nick Bosa has put up 29 tackles, 11.0 TFL, and 10.0 sacks in 2022.
  • Fred Warner has 75 tackles, 5.0 TFL, 3.0 sacks, and six passes defended.
  • Talanoa Hufanga has put up four interceptions (third in the NFL) and also has 56 tackles, 3.0 TFL, 1.0 sack, and seven passes defended.
  • Dre Greenlaw has 2.0 TFL and 73 tackles on the year.


  • Andy Dalton has thrown for 1,819 yards this year, with 14 touchdowns and seven interceptions. He is completing 66.9% of his passes while averaging 227.4 yards per game and 7.5 per attempt.
  • Alvin Kamara has scored one rushing touchdown, while totaling 511 rushing yards (4.1 per attempt and 56.8 per game).
  • Kamara has also collected 385 receiving yards (42.8 per game) on 43 catches (4.8 per game). He’s been targeted 58 times and has caught two touchdown passes.
  • Through 10 games played this season, Chris Olave has 51 catches (5.1 receptions per game on 8.3 targets per game) for 760 yards and three receiving touchdowns.
  • Taysom Hill has been targeted six times, resulting in four catches for 24 yards .
  • Demario Davis has 69 tackles, 8.0 TFL, 7.0 sacks, and two passes defended in 2022.
  • Tyrann Mathieu has 56 tackles, 1.0 TFL, and two interceptions. He is third on the Saints in tackles.
  • Kaden Elliss has 34 tackles, 3.0 TFL, and 4.5 sacks in the 2022 campaign.
  • Paulson Adebo’s season stats include 41 tackles and 2.0 TFL through eight games. He is fifth on the Saints in tackles.

49ers vs. Saints Predictions and Pick

Our prediction to win this game is the 49ers, and we project that 49ers will cover the spread (49ers -9). Finally, we see the scoring in this one going over the posted total of 43 points.

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How to Bet on 49ers vs. Saints

You can bet on 49ers vs. Saints at every legal online sportsbook. For more NFL odds, including moneylines, spreads, over/under totals as well as NFL prop odds, check out the latest NFL lines as well as our guide to the best NFL betting sites.

And if you wanted to check out how much you could win on a $10 bet if you parlayed today’s 49ers vs. Saints picks, don’t forget to check out our free parlay calculator.

Not sure what a parlay is? Or even how to bet on football? Check out our complete guide to sports betting.


Luis Escalante

Luis has been a regular contributor to 4for4 since 2014 and is currently the Director of Strategy at Betsperts Group. Luis comes from an analytics background, leveraging his data skills with multiple years of experience in NFL, fantasy football, daily fantasy sports, and betting.

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