Rams vs 49ers Prediction: Odds, Picks & Betting Preview Week 8 – October 2022

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The San Francisco 49ers (3-4) visit a fellow NFC West team on Sunday, October 30, 2022, when they face the Los Angeles Rams (3-3) at SoFi Stadium.

49ers vs. Rams Odds

Point Spread

The spread for this matchup is set at 1 point, with bookmakers listing the 49ers as the favorites.

Moneyline

As for the moneyline, the 49ers have -110 odds to pick up the win, while the Rams are listed at -110 to claim victory.

Over/Under

Finally, the over/under for the game is set at 42 points.

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Game Info

How to Watch 49ers vs. Rams Live?

  • Game Day: Sunday, October 30, 2022
  • Game Time: 4:25 PM ET
  • TV Channel: FOX
  • Location: Inglewood, California
  • Stadium: SoFi Stadium

Betting Preview

49ers

On defense, the 49ers have been a top-five unit, ranking third-best by giving up only 294.9 yards per game. They rank 14th on offense (355.0 yards per game). On offense, the 49ers rank 20th in the NFL with 20.7 points per game. Meanwhile, they rank ninth in points allowed (294.9 points allowed per contest).

The 49ers rank 14th in pass offense (234.3 passing yards per game) and 10th in pass defense (203.9 passing yards allowed per game) this year. The 49ers sport the 15th-ranked offense this season in terms of rushing yards (120.7 per game), and they’ve been more effective on defense, ranking second-best with just 91.0 rushing yards allowed per game.

The 49ers rank seventh in third-down efficiency (43.2%) on offense and 12th in third-down conversion rate allowed (38.7%) on defense this year. The 49ers have the fifth-best defense in the NFL in terms of yards per play allowed (4.9), while their offense is ranked ninth, accumulating 5.8 per play. The 49ers have forced nine total turnovers (14th in NFL) this season and have turned it over 12 times (27th in NFL) for a turnover margin of -3, 25th-ranked in the league.

Rams

The Rams’ defensive unit has been leading the way for the team, as they rank fifth-best in the NFL with 301.3 total yards ceded per game. In terms of offense, they are putting up 309.8 total yards per game, which ranks 26th. The Rams’ offense has been bottom-five this season, generating 17.3 points per game, which ranks fourth-worst in the NFL. Defensively, they rank 16th with 21.0 points allowed per contest.

In terms of passing, the Rams rank 11th in the NFL (239.3 passing yards per game) and eighth on defense (197.2 passing yards allowed per game). The Rams rank second-worst in rushing yards per game (70.5), but they’ve been better on the defensive side of the ball, ranking 10th in the NFL with 104.2 rushing yards allowed per contest.

With a 42.7% third-down conversion rate on offense, the Rams rank eighth in the NFL. Defensively, they rank 15th, giving up a 40.0% third-down rate. With 5.0 yards per play on offense, the Rams rank 27th in the NFL. Defensively they rank 10th, surrendering 5.3 yards per play. The Rams have forced eight turnovers this season and have turned it over 13 times, resulting in a -5 turnover margin that is fifth-worst in the NFL.

49ers vs. Rams Injury Report

49ers

Player Pos. Injury Status
Deebo Samuel WR Hamstring Out
Kyle Juszczyk FB Finger Out
Jauan Jennings WR Hamstring Questionable
Dre Greenlaw LB Calf Out
Jason Verrett CB Knee Questionable

Rams

Player Pos. Injury Status
Cam Akers RB Personal Out
Brandon Powell WR Ankle Questionable
Kyren Williams RB Ankle Questionable

49ers vs. Rams Betting Analysis

49ers Betting Insights

The 49ers have covered the spread three times this season (3-4-0). The 49ers are 3-3 ATS when playing as at least 1-point favorites.

Games involving the 49ers have hit the over twice this season. The 49ers won 57.1% of the games last season when they were favored on the moneyline (8-6).

The 49ers went 8-6 when playing as a moneyline favorite with odds of -110 or shorter (57.1%).

Rams Betting Insights

The Rams have covered the spread two times this season (2-4-0). The Rams have not covered a spread (0-2) when they are at least 1-point underdogs.

This year, Rams games have hit the over once. The Rams have lost both games they’ve played as underdogs this season.

The Rams have not won as an underdog of -110 or more on the moneyline this season in two such games.

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49ers vs. Rams Against The Spread & Betting Records

49ers

Overall Home Away
Point Total AVG 42.7 43.3 42.3
Implied Total AVG 23.1 23.0 23.3
ATS Record 3-4-0 2-1-0 1-3-0
Over/Under Record 2-5-0 1-2-0 1-3-0
Moneyline Favorite Record 3-3 2-0 1-3
Moneyline Underdog Record 0-1 0-1 0-0

Rams

Overall Home Away
Point Total AVG 45.1 45.0 45.3
Implied Total AVG 25.2 25.8 24.0
ATS Record 2-4-0 1-3-0 1-1-0
Over/Under Record 1-5-0 1-3-0 0-2-0
Moneyline Favorite Record 3-1 2-1 1-0
Moneyline Underdog Record 0-2 0-1 0-1

Players to Watch

49ers

  • On the ground, Christian McCaffrey averages 4.6 yards per attempt (25th in the NFL) and 61.6 yards per game for 431 total rushing yards. He has scored two rushing touchdowns this season.
  • McCaffrey has 44 targets, 35 receptions, 301 receiving yards and one TD in the passing game.
  • Jimmy Garoppolo has thrown for 1,456 yards, nine touchdowns (10th in the NFL) and four interceptions this year. He is averaging 242.7 yards per game and 7.9 per attempt, while completing 64.3%.
  • He has also rushed for 20 yards (eighth on the 49ers) and added one touchdown on the ground, while averaging 3.3 rushing yards per game.
  • Deebo Samuel has two touchdown catches this season, and has 32 catches for 387 yards on 55 targets, while averaging 4.6 catches and 55.3 yards per game.
  • Jeff Wilson Jr. has rushed for 454 yards, averaging 64.9 yards per game and scoring two touchdowns.
  • On the defensive side, Talanoa Hufanga has three interceptions (third in the NFL) to go with 40 tackles, 3.0 TFL, 1.0 sack, and six passes defended in 2022.
  • Nick Bosa has 19 tackles, 6.0 TFL, and 7.0 sacks this season.
  • Fred Warner has collected 50 tackles, 2.0 TFL, 1.0 sack, and two passes defended.
  • Dre Greenlaw has 57 tackles and 2.0 TFL.

Rams

  • This year, Cooper Kupp has 56 receptions (second in the NFL) for 607 yards (fifth in the NFL) with four receiving touchdowns (sixth in the NFL). He has been targeted 72 times and averages 9.3 catches per game through six games played.
  • Through six games, Matthew Stafford has 1,576 passing yards, while throwing six touchdowns against eight interceptions and completing 71.1% of his passes.
  • Darrell Henderson has rushed for two touchdowns this year, and has totaled 181 rushing yards (30.2 per game and 3.9 per carry).
  • Henderson has helped out in the passing attack, picking up 77 receiving yards (12.8 per game) on 14 catches (2.3 per game), while being targeted 18 times. He is seeking his first receiving touchdown.
  • Ben Skowronek has 221 receiving yards from 23 receptions after getting 29 targets.
  • Bobby Wagner has 46 tackles, 1.0 TFL, 2.0 sacks, and one pass defended in 2022.
  • Jalen Ramsey has registered 2.0 sacks in addition to his 3.0 TFL, 23 tackles, and one interception over six games.
  • Aaron Donald has 25 tackles, 5.0 TFL, 4.0 sacks, and one pass defended during the 2022 season.
  • Ernest Jones’ season stats include 42 tackles and 1.0 TFL in six games. He is second on the Rams in tackles.

49ers vs. Rams Predictions and Pick

Our pick to win this matchup is the Rams, and we predict that Rams will cover the spread (49ers -1). Finally, we see the scoring in this one going under the posted total of 42 points.

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How to Bet on 49ers vs. Rams

You can bet on 49ers vs. Rams at every legal online sportsbook. For more NFL odds, including moneylines, spreads, over/under totals as well as NFL prop odds, check out the latest NFL lines as well as our guide to the best NFL betting sites.

And if you wanted to check out how much you could win on a $10 bet if you parlayed today’s 49ers vs. Rams picks, don’t forget to check out our free parlay calculator.

Not sure what a parlay is? Or even how to bet on football? Check out our complete guide to sports betting.

WRITTEN BY

Andy Molitor

Andy has been involved in sports betting on and off his entire adult life and has been creating content surrounding it for the past five years. While the NFL is his first love, he also bets hundreds of college basketball games every winter and loves sweating golf DFS during the football offseason.

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