Eagles vs 49ers Prediction: Odds, Picks & Betting Preview Week 13 – December 3, 2023

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The San Francisco 49ers (8-3) are flying high on a three-game winning streak as they head into their road matchup on December 3, 2023 against a streaking Philadelphia Eagles squad (10-1) that has piled up five straight Ws.

49ers vs. Eagles Odds

Point Spread

The spread for this matchup is set at 3 points, with oddsmakers listing the 49ers as the favorites.


As for the moneyline, the 49ers have -148 odds to pick up the win, while the Eagles are listed at +124 to claim victory.


Finally, the over/under for the game is set at 46.5 points.

Game Info

How to Watch 49ers vs. Eagles Live?

  • Game Day: Sunday, December 3, 2023
  • Game Time: 4:25 PM ET
  • TV Channel: FOX
  • Location: Philadelphia, Pennsylvania
  • Stadium: Lincoln Financial Field

Betting Preview


The 49ers have been thriving on both sides of the ball, ranking third-best in total offense (386.1 yards per game) and fifth-best in total defense (295.3 yards allowed per game). The 49ers have been a handful for opposing teams, as they rank top-five in both scoring offense (third-best with 28.2 points per game) and scoring defense (best with 15.5 points allowed per game) this year.

From an offensive standpoint, the 49ers rank eighth in the NFL with 250.1 passing yards per game. Meanwhile, they rank 12th in passing yards allowed per contest (213.3). The 49ers rank seventh in rushing yards this season (136 rushing yards per game), but they’ve been thriving on defense, ranking second-best in the NFL with 82 rushing yards allowed per game.

On offense, the 49ers have been a top-five unit in terms of third-down efficiency, ranking fifth-best in the NFL by putting up a 44.4% third-down percentage. They rank 21st on defense (39.9% third-down percentage allowed). The 49ers have been clicking on all fronts in terms of yards per play this year, as they rank second-best in offensive yards per play (6.4) and third-best in yards per play allowed on defense (4.8). The 49ers have forced 21 total turnovers (second in NFL) this season and have turned it over 10 times (third in NFL) for a turnover margin of +11, the best in the league.


The Eagles are putting up 364.3 total yards per game on offense this season (ninth-ranked). Meanwhile, they are surrendering 341 total yards per contest (19th-ranked). The Eagles’ offense has been thriving, compiling 28.2 points per contest (third-best) this season. Defensively, they rank 20th by giving up 22.4 points per game.

The Eagles’ defense has been a bottom-five unit in pass defense this season, surrendering 255.7 passing yards per game, which ranks fourth-worst in the NFL. On the offensive side of the ball, they rank 14th with 231 passing yards per contest. The Eagles have been dominant on run defense, giving up only 85.3 rushing yards per contest (third-best). On offense, they rank eighth in the NFL by posting 133.3 rushing yards per game.

While the Eagles’ third-down defense has had trouble stopping opposing offenses, ranking third-worst by giving up a 45.5% third-down conversion rate, their offense ranks third-best with a 47.3% third-down rate. With 5.4 yards per play on offense, the Eagles rank 10th in the NFL. On defense they rank 12th, giving up 5.2 yards per play. The Eagles have compiled 14 forced turnovers (20th in NFL) and committed 16 turnovers (18th in NFL) this season for a -2 turnover margin that ranks 19th in the NFL.

49ers vs. Eagles Injury Report


Player Pos. Injury Status
Jordan Mason RB Hamstring Probable
Tyrion Davis-Price RB Gameday inactive Out
Ray-Ray McCloud WR Rib Out
Brandon Allen QB Gameday inactive Out
Brayden Willis TE Gameday inactive Out
Jalen Graham LB Gameday inactive Out


Player Pos. Injury Status
Rashaad Penny RB Gameday inactive Out
Fletcher Cox DT Groin Probable
Zech McPhearson CB Achilles Out
Iosua Opeta OG Gameday inactive Out
Dallas Goedert TE Forearm Out
Grant Calcaterra TE Ankle Probable
Zach Cunningham LB Hamstring Out
Tanner McKee QB Gameday inactive Out

49ers vs. Eagles Betting Analysis

49ers Betting Insights

The 49ers have covered the spread six times this season (6-5-0). The 49ers are 5-5 ATS when playing as at least 3-point favorites.

Games involving the 49ers have hit the over five times this season.

Eagles Betting Insights

The Eagles have put together a 7-2-2 record against the spread this season.

This year, Eagles games have hit the over six times. The Eagles won the only game they’ve played as the underdog this season.

The Eagles have not entered a game this season as a bigger underdog on the moneyline than the +124 odds on them winning this game.

49ers vs. Eagles Against The Spread & Betting Records


Overall Home Away
Point Total AVG 43 43.8 42.3
Implied Team Total AVG 25.5 26.8 24.3
ATS Record 6-5-0 3-2-0 3-3-0
Over/Under Record 5-5-1 3-2-0 2-3-1
Moneyline Favorite Record 8-3 4-1 4-2
Moneyline Underdog Record 0-0 0-0 0-0


Overall Home Away
Point Total AVG 46.4 48 45
Implied Team Total AVG 25.7 26.6 25
ATS Record 7-2-2 3-1-1 4-1-1
Over/Under Record 6-5-0 4-1-0 2-4-0
Moneyline Favorite Record 9-1 5-0 4-1
Moneyline Underdog Record 1-0 0-0 1-0

Players to Watch


  • Christian McCaffrey has put up 939 rushing yards (first in the NFL) with 11 touchdowns (85.4 yards per game over 11 games). His 4.9 yards per attempt rank ninth in the NFL.
  • McCaffrey has 58 targets, 48 receptions, 389 receiving yards and five TDs through the air.
  • Brock Purdy has passed for 2,871 yards (ninth in the NFL), 19 touchdowns (seventh in the NFL) and six interceptions this year. He is averaging 261 yards per game and 9.4 per attempt, while completing 70.2%.
  • He has added 122 rushing yards (11.1 per game) and two touchdowns on the ground.
  • In the passing attack, Brandon Aiyuk, has racked up 881 receiving yards (10th in the NFL) and five touchdowns after grabbing 45 balls on 65 targets. Per game, he’s averaging 88.1 yards and 4.5 receptions through 10 games.
  • George Kittle has racked up 667 receiving yards and five touchdowns with 46 catches on 61 targets. He is averaging 4.2 receptions and 60.6 yards per game.
  • On the defensive side for the 49ers, Fred Warner has racked up 96 tackles, five TFL, 2.5 sacks, and three interceptions in 2023.
  • Nick Bosa has 33 tackles, nine TFL, 7.5 sacks, and two passes defended.
  • Dre Greenlaw has recorded 79 tackles, five TFL, and 1.5 sacks this year.
  • So far this season, Charvarius Ward has 51 tackles, one TFL, and two interceptions. He’s fourth on the 49ers in tackles.


  • Jalen Hurts is averaging 7.5 passing yards per attempt (seventh in the NFL) and 245.2 yards per game this year, completing 67.6% of his passes on the way to 2,697 total yards, 18 touchdowns (10th in the NFL) and 10 interceptions through 11 games.
  • On the ground, Hurts has added 11 rushing touchdowns and 410 rushing yards (second on the Eagles).
  • A.J. Brown has put together a 2023 campaign that includes 73 catches (10th in the NFL) for 1,050 yards (fourth in the NFL) and seven receiving touchdowns (fifth in the NFL) in 11 games played. He has been on the receiving end of 105 targets and is averaging 6.6 receptions per game.
  • This season through 11 games, D’Andre Swift has churned out 770 rushing yards (leading the Eagles and fourth in the NFL) and scored four rushing touchdowns. He averages 70 yards per game and 4.8 per attempt (11th in the NFL).
  • Swift’s offensive output includes 34 receptions (3.1 per game) on 39 targets for 201 yards (18.3 per game) and one receiving touchdown.
  • DeVonta Smith has been targeted 76 times, resulting in 55 catches for 738 yards .
  • Reed Blankenship has intercepted two passes to go with 70 tackles, two TFL, and 10 passes defended in 2023.
  • Kevin Byard has 85 tackles and one interception.
  • Josh Sweat has 6.5 sacks (second on the Eagles) in addition to his six TFL and 30 tackles.
  • Haason Reddick has 8.5 sacks (first on the Eagles) as well as nine TFL and 25 tackles.

49ers vs. Eagles Predictions and Pick

Our prediction to win this matchup is the 49ers, and we project that 49ers will cover the spread (49ers -3). Finally, we see the scoring in this one going over the posted total of 46.5 points.

How to Bet on 49ers vs. Eagles

You can bet this 49ers vs. Eagles pick at every legal online sportsbook

You can check our live NFL lines for the latest NFL odds, including money lines, spreads, and over/under totals.

Tip: If you want to check out how much you could win on a $10 bet if you parlayed today’s 49ers vs. Eagles picks, don’t forget to check out our free parlay calculator.

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Matt Rooney

Matt comes from Chicago and has lived in the area his whole life. Graduated from and played football at Illinois Wesleyan University in Bloomington, IL while also serving as the director of student sports broadcasting. He writes for Betsperts as well as appears on several shows across the network.

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