Cardinals vs 49ers Prediction: Odds, Picks & Betting Preview Week 18 – January 8, 2023

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The streaking San Francisco 49ers (12-4) bring a nine-game winning streak into a home meeting against the Arizona Cardinals (4-12) on Sunday, January 8, 2023 at Levi’s Stadium.

49ers vs. Cardinals Odds

Point Spread

The spread for this matchup is set at 14 points, with oddsmakers listing the 49ers as the favorites.


As for the moneyline, the 49ers have -975 odds to pick up the win, while the Cardinals are listed at +675 to claim victory.


Finally, the over/under for the game is set at 39.5 points.

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Game Info

How to Watch 49ers vs. Cardinals Live?

  • Game Day: Sunday, January 8, 2023
  • Game Time: 4:25 PM ET
  • TV Channel: FOX
  • Location: Santa Clara, California
  • Stadium: Levi’s Stadium

Betting Preview


The 49ers have been thriving on both sides of the ball, ranking fifth-best in total offense (369.1 yards per game) and second-best in total defense (303.4 yards allowed per game). The 49ers have the seventh-ranked offense this year (25.8 points per game), and they’ve been better on defense, ranking best with only 16.5 points allowed per game.

The 49ers rank 13th in pass offense (232.1 passing yards per game) and 19th in pass defense (224.7 passing yards allowed per game) this year. The 49ers own the ninth-ranked offense this year in terms of rushing yards (136.9 per game), and they’ve been more effective on the other side of the ball, ranking best with only 78.8 rushing yards allowed per game.

The 49ers rank sixth in third-down efficiency (44.9%) on offense and 15th in third-down percentage allowed (38.9%) on defense this year. The 49ers have been finding success on both offense and defense in terms of yards per play, ranking fourth-best in yards per play on offense (6.0) and third-best in yards per play allowed on defense (5.0). The 49ers have the second-best turnover margin in the league at +9, forcing 26 turnovers (fourth in NFL) while turning it over 17 times (third in NFL).

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The Cardinals rank 21st with 327.8 total yards per game on offense, and they rank 21st with 351.3 total yards allowed per contest on the defensive side of the ball. The Cardinals have been sputtering on defense, ranking fourth-worst with 25.7 points surrendered per game. They have been better on the other side of the ball, generating 20.4 points per contest (21st-ranked).

With 214.5 passing yards per game on offense, the Cardinals rank 18th in the NFL. Defensively, they rank 25th, surrendering 235.8 passing yards per contest. With 113.3 rushing yards per game on offense, the Cardinals rank 20th in the NFL. On defense they rank 13th, allowing 115.4 rushing yards per contest.

From an offensive perspective, the Cardinals are putting up a 35.0% third-down conversion rate (27th-ranked). They rank 27th in the NFL on the other side of the ball (42.6% third-down rate allowed). The Cardinals rank fourth-worst in yards per play (4.8), but they’ve been better on the defensive side of the ball, ranking 18th in the NFL with 5.5 yards surrendered per play. The Cardinals have registered 20 forced turnovers (16th in NFL) and committed 21 turnovers (15th in NFL) this season for a -1 turnover margin that ranks 17th in the NFL.

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49ers vs. Cardinals Injury Report


Player Pos. Injury Status
Ambry Thomas CB Ankle Out
Javon Kinlaw DT Back Questionable
Dre Greenlaw LB Back Out


Player Pos. Injury Status
James Conner RB Shin Out
Colt McCoy QB Concussion Out
Josh Jackson CB Hamstring Questionable
Zach Allen DE Hand Out
Zaven Collins ILB Calf Out
DeAndre Hopkins WR Knee Out
Robby Anderson WR Back Out
Marco Wilson CB Neck Out
Antonio Hamilton CB Hip Out
Leki Fotu DT Shoulder Questionable
Tanner Vallejo ILB Knee Questionable
Victor Dimukeje OLB Illness Questionable

49ers vs. Cardinals Betting Analysis

49ers Betting Insights

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The 49ers have put together a record of 10-6-0 against the spread this season.

49ers games have gone over the total eight times this season. The 49ers were favored on the moneyline 14 total times last season. They finished 8-6 in those games.

The 49ers never played a game last season with moneyline odds of -975 or shorter.

Cardinals Betting Insights

The Cardinals have put together a record of 8-8-0 against the spread this season.

Cardinals games have finished with a final combined score above the over/under seven times this year. This season, the Cardinals have won three out of the 13 games, or 23.1%, in which they’ve been the underdog.

The Cardinals have not entered a game this season as a bigger underdog on the moneyline than the +675 odds on them winning this game.

49ers vs. Cardinals Against The Spread & Betting Records


Overall Home Away
Point Total AVG 42.4 42.6 42.2
Implied Total AVG 23.7 23.9 23.5
ATS Record 10-6-0 6-2-0 4-4-0
Over/Under Record 8-8-0 4-4-0 4-4-0
Moneyline Favorite Record 11-3 7-0 4-3
Moneyline Underdog Record 1-1 0-1 1-0


Overall Home Away
Point Total AVG 45.8 46.8 44.4
Implied Total AVG 25.0 25.8 24.0
ATS Record 8-8-0 4-5-0 4-3-0
Over/Under Record 7-8-1 4-4-1 3-4-0
Moneyline Favorite Record 1-2 1-1 0-1
Moneyline Underdog Record 3-10 0-7 3-3

Players to Watch


  • On the ground, Christian McCaffrey averages 4.7 yards per attempt (18th in the NFL) and 68.4 yards per game for 1,094 total rushing yards (ninth in the NFL). He has recorded eight rushing touchdowns this season.
  • He has also caught 82 passes (on 104 targets) for 707 receiving yards with four touchdowns. He’s averaging 44.2 receving yards and 5.1 catches per game.
  • Brandon Aiyuk‘s 956 receiving yards this season have come from 108 targets and 74 receptions. He’s averaging 59.8 receiving yards and 4.6 catches per game, with eight receiving touchdowns (seventh in the NFL).
  • George Kittle has nine touchdown catches this season (fifth in the NFL), and has 56 receptions for 736 yards on 80 targets, while averaging 4.0 catches and 52.6 yards per game.
  • Deebo Samuel has racked up 612 receiving yards and two touchdowns with 54 catches on 92 targets. He’s averaging 4.5 receptions and 51.0 yards per game.
  • On the defensive side, Nick Bosa has 47 tackles, 17.0 TFL, and 17.0 sacks in 2022.
  • Fred Warner has 126 tackles, 5.0 TFL, 3.0 sacks, and one interception this season. His tackle total leads the 49ers.
  • Talanoa Hufanga has recorded four interceptions (ninth in the NFL) and added 91 tackles, 3.0 TFL, 2.0 sacks, and nine passes defended.
  • So far this season, Charvarius Ward has 84 tackles, 3.0 TFL, and one interception. He’s fourth on the 49ers in tackles.


  • Marquise Brown has totaled 702 receiving yards and three touchdowns on 66 receptions, while being targeted 103 times this season.
  • Greg Dortch has 48 catches for 437 yards and two receiving touchdowns. He has been targeted 60 times and averages 3.2 receptions per game through 15 games played.
  • So far this season, Trey McBride has caught 26 passes for 224 receiving yards with one touchdown through the air. He has been targeted 36 total times and is averaging 1.7 receptions per game in 15 games played.
  • A.J. Green has 21 catches for 145 yards and one receiving touchdown. He averages 1.5 yards per game in 14 games and has been targeted 42 times.
  • Isaiah Simmons has intercepted two passes in addition to 90 tackles, 4.0 TFL, 3.0 sacks, and seven passes defended in 2022.
  • J.J. Watt’s stats include 34 tackles, 15.0 TFL, 10.5 sacks, and six passes defended.
  • Over the 2022 season, Jalen Thompson has 101 tackles and one interception through 16 games.
  • Markus Golden has 2.5 sacks (fifth on the Cardinals) as well as 7.0 TFL and 46 tackles.

49ers vs. Cardinals Predictions and Pick

Our pick to win this contest is the 49ers, and we project that 49ers will cover the spread (49ers -14). Finally, we see the scoring in this one going over the posted total of 39.5 points.

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How to Bet on 49ers vs. Cardinals

You can bet on 49ers vs. Cardinals at every legal online sportsbook. For more NFL odds, including moneylines, spreads, over/under totals as well as NFL prop odds, check out the latest NFL lines as well as our guide to the best NFL betting sites.

And if you wanted to check out how much you could win on a $10 bet if you parlayed today’s 49ers vs. Cardinals picks, don’t forget to check out our free parlay calculator.

Not sure what a parlay is? Or even how to bet on football? Check out our complete guide to sports betting.


Luis Escalante

Luis has been a regular contributor to 4for4 since 2014 and is currently the Director of Strategy at Betsperts Group. Luis comes from an analytics background, leveraging his data skills with multiple years of experience in NFL, fantasy football, daily fantasy sports, and betting.

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