Broncos vs 49ers Prediction: Odds, Picks & Betting Preview Week 3 – September 2022

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Sunday, September 25, 2022 will see the San Francisco 49ers (1-1) hit the road to trade blows with the Denver Broncos (1-1) at Empower Field at Mile High.

49ers vs. Broncos Odds

Point Spread

The spread for this matchup is set at 1.5 points, with bookmakers listing the 49ers as the favorites.


As for the moneyline, the 49ers have -120 odds to pick up the win, while the Broncos are listed at +100 to claim victory.


Finally, the over/under for the game is set at 44.5 points.

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Game Info

How to Watch 49ers vs. Broncos Live?

  • Game Day: Sunday, September 25, 2022
  • Game Time: 8:20 PM ET
  • TV Channel: NBC
  • Location: Denver, Colorado
  • Stadium: Empower Field at Mile High

Betting Preview


The 49ers sport the 15th-ranked offense this season (352.0 yards per game), and they’ve been even more effective defensively, ranking best with just 210.0 yards allowed per game. The 49ers own the 19th-ranked offense this year (18.5 points per game), and they’ve been more effective on defense, ranking third-best with only 13.0 points allowed per game. While the 49ers rank fourth-worst in the NFL in passing offense with 169.5 passing yards per game, it’s been a different situation defensively, as they rank best (142.5 passing yards per game allowed). The 49ers have been a difficult matchup for opposing teams in the running game, as they rank top-five in both rushing offense (fourth-best with 182.5 rushing yards per game) and rushing defense (second-best with 67.5 rushing yards allowed per game) this season. The 49ers rank 13th in third-down efficiency (43.8%) on offense and eighth in third-down percentage allowed (33.3%) on defense this year. The 49ers are accumulating 5.1 yards per play on offense (21st in the league), while featuring the second-best yards per play on defense in the NFL (4.1) this season. The 49ers own the seventh-ranked turnover margin in the league at +2, forcing four turnovers (sixth in NFL) while turning it over two times (10th in NFL).


The Broncos have been dominant on defense, allowing only 243.5 total yards per contest (third-best). Offensively, they rank seventh by putting up 391.5 total yards per game. The Broncos have been keeping opposing offenses in check on defense, surrendering just 13.0 points per game (third-best). Offensively, they rank 24th by posting 16.0 points per game. The Broncos’ pass defense has been leading the way for the team, as they rank fifth-best in the NFL with 165.5 passing yards allowed per contest. In terms of offense, they are posting 265.5 passing yards per game, which ranks eighth. The Broncos’ run defense has been leading the way for the team, as they rank fourth-best in the NFL with 78.0 rushing yards allowed per game. In terms of offense, they are putting up 126.0 rushing yards per game, which ranks 10th. In terms of third-down efficiency, the Broncos rank 15th in the NFL (40.7% third-down conversion rate) and eighth on the other side of the ball (33.3% third-down rate allowed). The Broncos have been dominant on defense in terms of yards per play, allowing only 4.5 (fifth-best). Offensively, they rank seventh in the NFL by posting 6.1 yards per play. The Broncos have recorded one forced turnover (23rd in NFL) and committed three turnovers (16th in NFL) this season for a -2 turnover margin that ranks 22nd in the NFL.

49ers vs. Broncos Injury Report


49ers: FB Arik Armstead: Questionable (Foot), FB Daniel Brunskill: Out (Hamstring), RB Tyrion Davis-Price: Out (Ankle), QB Trey Lance: Out (Ankle), TE Tyler Kroft: Out (Knee), FB Colton McKivitz: Questionable (Ankle)


Broncos: FB Billy Turner: Questionable (Knee), ILB Josey Jewell: Questionable (Knee), WR Jerry Jeudy: Questionable (Knee), CB Darius Phillips: Out (Hamstring), CB Patrick Surtain II: Questionable (Shoulder), WR K.J. Hamler: Questionable (Hip), FB Mike Purcell: Questionable (Elbow), OLB Jonathon Cooper: Questionable (Hamstring), WR Tyrie Cleveland: Questionable (Hamstring), DE Dre’Mont Jones: Questionable (Neck), FB Quinn Meinerz: Questionable (Hamstring)

49ers vs. Broncos Betting Analysis

49ers Betting Insights

The 49ers have put together a record of 1-1-0 against the spread this season. The 49ers are 1-1 ATS when playing as at least 1.5-point favorites. 49ers games have yet to go over the total once this season. The 49ers finished with an 8-6 record in games they were favored on the moneyline last season (winning 57.1% of those games). The 49ers finished 8-6 last year (winning 57.1% of their games) when they played as a moneyline favorite of -120 or shorter.

Broncos Betting Insights

The Broncos have not covered the spread this year (0-2-0). Broncos games have yet to go over the total once this season. This is the first time the Broncos will play as underdogs this season. The Broncos have not been a bigger underdog this season than the +100 moneyline set for this game.

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49ers vs. Broncos Against The Spread & Betting Records


Overall Home Away
Point Total AVG 39.0 39.5 38.5
Implied Total AVG 23.0 24.0 22.0
ATS Record 1-1-0 1-0-0 0-1-0
Over/Under Record 0-2-0 0-1-0 0-1-0
Moneyline Favorite Record 1-1 1-0 0-1
Moneyline Underdog Record 0-0 0-0 0-0


Overall Home Away
Point Total AVG 44.5 45.5 43.5
Implied Total AVG 26.5 28.0 25.0
ATS Record 0-2-0 0-1-0 0-1-0
Over/Under Record 0-2-0 0-1-0 0-1-0
Moneyline Favorite Record 1-1 1-0 0-1
Moneyline Underdog Record 0-0 0-0 0-0

Players to Watch


  • Deebo Samuel has brought in seven passes on 14 targets for 58 total yards and zero touchdowns. He is averaging 3.5 catches and 29.0 yards per game over two games played.
  • Jimmy Garoppolo has 154 passing yards, one touchdown and zero interceptions this year. He has completed 61.9% of his passes, averaging 154.0 yards per game and 7.3 per attempt.
  • He has rushed for 5 yards (seventh on the 49ers) and added one touchdown on the ground, while averaging 5.0 rushing yards per game.
  • Jeff Wilson Jr.‘s output on the ground this season includes 106 yards with no rushing touchdowns. He is averaging 53.0 yards per game and 3.9 per attempt (36th in the NFL).
  • Wilson has received four targets in the passing game and has four catches (2.0 per game) for 27 yards (13.5 per game) and zero TDs.
  • Brandon Aiyuk has seven receptions for 103 yards and zero touchdowns. He’s been targeted 10 times in the passing game, and averages 3.5 receptions and 51.5 yards in two games played.
  • On defense, Nick Bosa has nine tackles, 2.0 TFL, and 3.0 sacks in 2022.
  • Talanoa Hufanga has 17 tackles, 1.0 TFL, and one interception this season. His tackle total leads the 49ers.
  • This season, Dre Greenlaw has put up 1.0 TFL and 12 tackles.
  • Charvarius Ward has one interception (sixth in the NFL) while tacking on nine tackles and two passes defended.


  • Russell Wilson is averaging 7.7 passing yards per attempt (sixth in the NFL) and 279.5 yards per game this year, completing 58.9% of his passes on the way to 559 total yards (10th in the NFL), two touchdowns and one interception through two games.
  • Courtland Sutton has 194 receiving yards (10th in the NFL) on 11 receptions, while being targeted 18 times.
  • Jerry Jeudy has put up 113 receiving yards and one touchdown on five receptions, while being targeted 10 times this season.
  • Javonte Williams puts up 59.0 rushing yards per game over two games (118 total yards), but has not yet scored a rushing touchdown.
  • Williams also has 75 receiving yards (37.5 per game) on 12 catches (6.0 per game). He has been targeted 16 times while he is still trying for his first receiving touchdown.
  • So far in 2022, Dre’Mont Jones has put up seven tackles, 1.0 TFL, and 2.0 sacks over two games.
  • Randy Gregory’s stats include four tackles, 1.0 TFL, and 1.0 sack.
  • Bradley Chubb has six tackles and 2.0 sacks in the 2022 season.
  • Ronald Darby has seven tackles and two passes defended.

49ers vs. Broncos Predictions and Pick

Our pick to win this game is the 49ers, and we predict that 49ers will cover the spread (49ers -1.5). Finally, we see the scoring in this one going under the posted total of 44.5 points.

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How to Bet on 49ers vs. Broncos

You can bet on 49ers vs. Broncos at every legal online sportsbook. For more NFL odds, including moneylines, spreads, over/under totals as well as NFL prop odds, check out the latest NFL lines as well as our guide to the best NFL betting sites.

And if you wanted to check out how much you could win on a $10 bet if you parlayed today’s 49ers vs. Broncos picks, don’t forget to check out our free parlay calculator.

Not sure what a parlay is? Or even how to bet on football? Check out our complete guide to sports betting.


Brian Twining

Sports, of all kind, have been a huge part of my life and daily routine for as long as I can remember. My favorite sports to watch are College Basketball, College Football, the NFL, MLB, Nascar, & the FIFA World Cup. My favorite sports to bet on are the NFL, Nascar, College Hoops, and College Football.

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