White Sox vs Guardians Odds, Picks & Predictions – July 22

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The Cleveland Guardians (46-44) will visit the Chicago White Sox (46-46), Friday at 8:10 PM ET, in a clash of AL Central rivals. Lucas Giolito (6-5) is the starter for the White Sox, and Cal Quantrill (7-5) for the Guardians.

The White Sox are moderate favorites on the moneyline (-156) at home over the Guardians (+132). The total for this contest is set at 8.5.

White Sox vs. Guardians Odds

Run Line

Chicago White Sox (-1.5)


White Sox (-156)


8.5 Runs (Over: -111, Under: -110)

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When, Where, at What Time is White Sox vs. Guardians

  • Game Day: Friday, July 22, 2022
  • Game Time: 8:10 PM ET
  • Location: Chicago, Illinois
  • Stadium: Guaranteed Rate Field

White Sox Injury Report

Yasmani Grandal10 Day Injury ListBack
Jake Burger10 Day Injury ListHand
Aaron Bummer15 Day Injury ListBack
Kyle Crick15 Day Injury ListElbow
Vince Velásquez15 Day Injury ListFinger
Danny Mendick60 Day Injury ListKnee
Jonathan Stiever60 Day Injury ListBack
Garrett Crochet60 Day Injury ListElbow
Luis RobertDay-to-dayIllness
Eloy JiménezDay-to-dayLeg

Guardians Injury Report

Oscar Gonzalez10 Day Injury ListRibs
Anthony Gose15 Day Injury ListTricep
Aaron Civale15 Day Injury ListWrist
Cody Morris60 Day Injury ListShoulder

Last Time Out: White Sox and Guardians

The White Sox won their last contest versus the Twins by an 11-0 score Friday, with Dylan Cease picking up the win pitching going seven innings without giving up an earned run on one hit, while striking out eight. Andrew Vaughn went 3-for-4 with a double, a home run and three RBI to lead them offensively.

The Guardians beat the Tigers 10-0 Friday. Jose Ramirez went 2-for-4 with two home runs and five RBI, and Quantrill got the win, throwing six innings without giving up an earned run on four hits, while striking out five.

Betting Trends

White Sox Betting Records and Team Stats

This season, the White Sox have won 29 out of the 53 games, or 54.7%, in which they’ve been favored. This season, Chicago has won nine of its 19 games, or 47.4%, when favored by at least -156 on the moneyline. The White Sox have a 60.9% chance to win this game based on the implied probability of the moneyline. So far this season, Chicago and its opponents have hit the over in 42 of their 92 games with a total. The White Sox are 44-48-0 against the spread this season.

NameGPAVG (Rank)OBP (Rank)SLG (Rank)HR% (Rank)K% (Rank)BB% (Rank)
José Abreu90.304 (15).387 (10).470 (40)2.8% (86)14.7% (26)11.1% (37)
Luis Robert74.301 (18).334 (70).461 (45)3.7% (56)19.2% (70)4.0% (153)
Andrew Vaughn72.300 (19).349 (43).464 (44)3.3% (70)16.6% (44)5.9% (131)
Tim Anderson66.310 (9).351 (41).416 (80)2.1% (110)13.7% (19)4.1% (151)
A.J. Pollock73.227 (-).268 (-).333 (-)1.5% (-)21.3% (-)5.1% (-)

Guardians Betting Records and Team Stats

The Guardians have won in 18, or 38.3%, of the 47 contests they have been named as odds-on underdogs in this year. This season, Cleveland has been victorious nine times in 23 chances when named as an underdog of at least +132 or longer on the moneyline. The moneyline set for this matchup implies the Guardians have a 43.1% chance of walking away with the win. Cleveland’s games have gone over the total in 43 of their 90 opportunities. In 90 games with a line this season, the Guardians have a mark of 47-43-0 against the spread.

NameGPAVG (Rank)OBP (Rank)SLG (Rank)HR% (Rank)K% (Rank)BB% (Rank)
José Ramírez87.288 (30).368 (19).576 (6)5.1% (18)9.9% (4)10.7% (44)
Amed Rosario84.291 (28).327 (80).403 (96)1.1% (142)15.0% (30)4.7% (148)
Steven Kwan78.279 (37).361 (29).359 (136)0.3% (153)8.5% (2)10.1% (57)
Josh Naylor64.274 (-).328 (-).507 (-)5.3% (-)16.2% (-)7.3% (-)
Andrés Giménez79.296 (23).357 (34).478 (33)3.6% (57)21.8% (93)5.0% (144)

White Sox vs. Guardians Picks and Predictions

Our best pick for White Sox vs. Guardians is the White Sox (-156 on the moneyline) as the pick to win. As for the over/under, we pick the over on 8.5 runs.

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Matt Rooney

Matt comes from Chicago and has lived in the area his whole life. Graduated from and played football at Illinois Wesleyan University in Bloomington, IL while also serving as the director of student sports broadcasting. He writes for Betsperts as well as appears on several shows across the network.

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