Guardians vs White Sox Prediction: Picks, Live Odds & Start Time – September 22, 2022

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At Guaranteed Rate Field on Thursday, the Chicago White Sox play the Cleveland Guardians (three consecutive wins) at 8:10 PM ET. On the hill for the Guardians will be Shane Bieber (11-8), matched up against the White Sox’s Johnny Cueto (7-8).

Despite playing away from home the Guardians are at -139 to win, compared to the White Sox at +118. The contest has an over/under set at 7.5.

Guardians vs. White Sox Odds

Run Line

Cleveland Guardians (-1.5)

Moneyline

Guardians (-139)

Total

7.5 Runs (Over: +104, Under: -125)

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When, Where, at What Time is Guardians vs. White Sox

  • Game Day: Thursday, September 22, 2022
  • Game Time: 8:10 PM ET
  • Location: Chicago, Illinois
  • Stadium: Guaranteed Rate Field

Guardians Injury Report

Name Status Injury
Aaron Civale 15 Day Injury List Arm
Zach Plesac 15 Day Injury List Hand
Anthony Gose 60 Day Injury List Tricep

White Sox Injury Report

Name Status Injury
Tim Anderson 10 Day Injury List Hand
Michael Kopech 15 Day Injury List Shoulder
Danny Mendick 60 Day Injury List Knee
Kyle Crick 60 Day Injury List Elbow
Garrett Crochet 60 Day Injury List Elbow
Jonathan Stiever 60 Day Injury List Back
Luis Robert Day-to-day Hand / Wrist
Joe Kelly Bereavement List Personal

Last Time Out: Guardians and White Sox

Triston McKenzie (8.00 IP, 2 R, 6 H, 13 K) picked up the win in the Guardians’ 8-2 victory over the White Sox yesterday. Josh Naylor led the way offensively, going 1-for-3 with a home run and two RBI. Lance Lynn (6.00 IP, 3 R, 9 H, 3 K) was handed the loss for the White Sox.

Betting Trends

Guardians Betting Records and Team Stats

The Guardians have been favorites in 76 games this season and won 51 (67.1%) of those contests. Cleveland is 34-14 this season when entering a game favored by -139 or more on the moneyline. The oddsmakers’ moneyline implies a 58.2% chance of a victory for the Guardians. So far this season, Cleveland and its opponents have hit the over in 70 of their 153 games with a total. In 153 games with a spread this season, the Guardians are 79-74-0 ATS.

Name GP AVG (Rank) OBP (Rank) SLG (Rank) HR% (Rank) K% (Rank) BB% (Rank)
José Ramírez 145 .275 (35) .356 (28) .518 (10) 4.4% (31) 11.6% (7) 10.5% (31)
Steven Kwan 135 .299 (12) .375 (11) .395 (101) 0.9% (129) 9.1% (2) 10.2% (39)
Amed Rosario 142 .280 (28) .312 (96) .402 (91) 1.8% (114) 16.7% (38) 4.0% (132)
Andrés Giménez 136 .297 (14) .369 (16) .471 (28) 3.1% (69) 19.4% (68) 6.3% (106)
Josh Naylor 116 .258 (-) .318 (-) .453 (-) 4.1% (-) 15.5% (-) 7.2% (-)

White Sox Betting Records and Team Stats

The White Sox have been underdogs in 50 games this season and have come away with the win 23 times (46%) in those contests. Chicago has a mark of 11-15 in contests where sportsbooks favor them by +118 or worse on the moneyline. The White Sox have an implied victory probability of 45.9% according to the moneyline set for this matchup. Chicago and their opponents have hit the over in 68 of their 153 games with a total set by oddsmakers this season. The White Sox are 70-83-0 against the spread in their 153 games with a line set by sportsbooks this season.

Name GP AVG (Rank) OBP (Rank) SLG (Rank) HR% (Rank) K% (Rank) BB% (Rank)
José Abreu 147 .308 (7) .382 (9) .450 (48) 2.3% (97) 16.7% (38) 9.4% (50)
Andrew Vaughn 124 .285 (25) .335 (52) .453 (46) 3.3% (60) 16.4% (36) 5.6% (118)
Elvis Andrus 136 .258 (69) .315 (90) .412 (82) 2.7% (82) 15.9% (30) 7.3% (87)
A.J. Pollock 127 .243 (93) .290 (122) .387 (108) 2.7% (82) 18.9% (58) 6.0% (113)
Luis Robert 97 .284 (-) .319 (-) .426 (-) 3.0% (-) 19.2% (-) 4.2% (-)

Guardians vs. White Sox Picks and Predictions

Our prediction for Guardians vs. White Sox sees the White Sox (+118 on the moneyline) as the pick to win. As for the total, we prefer the over on 7.5 runs.

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WRITTEN BY

Matt Rooney

Matt comes from Chicago and has lived in the area his whole life. Graduated from and played football at Illinois Wesleyan University in Bloomington, IL while also serving as the director of student sports broadcasting. He writes for Betsperts as well as appears on several shows across the network.

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