Purdue vs. Nebraska Prediction: Picks & Start Time – October 2022

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The Purdue Boilermakers (4-2) and Nebraska Cornhuskers (3-3) will battle in clash of Big Ten rivals at Ross-Ade Stadium in West Lafayette, Indiana.

Purdue vs. Nebraska Odds

Point Spread

The spread for this matchup is set at 14 points, with oddsmakers listing Purdue as the favorites.


As for the moneyline, Purdue has -576 odds to pick up the win, while Nebraska is listed at +408 to claim victory.


Finally, the over/under for the game is set at 56.5 points.

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Game Info

How to Watch Purdue vs. Nebraska Live?

  • Game Day: Saturday, October 15, 2022
  • Game Time: 7:30 PM ET
  • TV Channel: BTN
  • Location: West Lafayette, Indiana
  • Stadium: Ross-Ade Stadium

Betting Preview


Purdue is totaling 419.7 yards per game on offense (56th in the FBS), and rank 26th defensively, yielding 327.8 yards allowed per game. Purdue is totaling 32.5 points per game on offense this year (48th in the FBS), and is allowing 22.0 points per game (41st) on defense. Purdue sports the 71st-ranked defense this season in terms of passing yards (230.8 allowed per game), and has been more effective on the other side of the ball, ranking 21st-best with 299.0 passing yards per game. Purdue sports the 99th-ranked offense this season in terms of rushing yards (120.7 per game), and has been more effective defensively, ranking 17th-best with just 97.0 rushing yards allowed per game. Defensively, Purdue has been a top-25 unit in terms of third-down efficiency, ranking 22nd-best by giving up a 30.6% third-down conversion rate. The team’s offense ranks 39th (44.8% third-down conversion rate). With 10 forced turnovers (36th in the FBS) against 11 turnovers committed (99th in the FBS), Purdue’s -1-1 turnover margin ranks 100th in college football.


Nebraska has sputtering defensively, ranking 16th-worst with 449.0 total yards surrendered per game. It has been better on offense, generating 415.5 total yards per contest (60th-ranked). From an offensive perspective, Nebraska is generating 28.5 points per game (77th-ranked). It ranks 89th in the FBS on the other side of the ball (29.3 points surrendered per game). With 255.3 passing yards per game on offense, Nebraska ranks 57th in the FBS. Defensively, it ranks 105th, allowing 263.0 passing yards per game. Nebraska has been struggling in run defense, ranking 22nd-worst with 186.0 rushing yards surrendered per game. It has been better on offense, generating 160.2 rushing yards per contest (61st-ranked). Nebraska’s third-down defense ranks 87th in the FBS with a 41.3% third-down conversion percentage surrendered, but it has been led by its offense, which ranks 21st-best by putting up a 48.3% third-down rate. Nebraska sports a -2 turnover margin this season, which ranks 100th in the FBS.

Purdue vs. Nebraska Betting Analysis

Purdue Betting Insights

Purdue has covered the spread three times over six games with a set spread. Purdue has an ATS record of 1-1 when playing as at least 14-point favorites. Purdue games have finished with a final combined score above the over/under four times this season. The Boilermakers have been the moneyline favorite just one other time so far this season, a game they won. The Boilermakers have played as a moneyline favorite of -576 or shorter in only one game this season, which they won.

Cornhuskers Betting Insights

Nebraska has covered the spread one time in five games with a set spread. Games involving Nebraska has hit the over once this season. The Cornhuskers lost the only game they’ve played as the underdog this season. The Cornhuskers have played as an underdog of +408 or more once this season and won that game.

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Purdue vs. Nebraska Against The Spread & Betting Records


Overall Home Away
Point Total AVG 55.8 54.3 57.2
Implied Total AVG 33.8 36.7 31.0
ATS Record 3-3-0 1-2-0 2-1-0
Over/Under Record 4-2-0 2-1-0 2-1-0
Moneyline Favorite Record 1-0 1-0 0-0
Moneyline Underdog Record 2-2 0-1 2-1


Overall Home Away
Point Total AVG 60.6 63.3 50.0
Implied Total AVG 37.6 40.3 27.0
ATS Record 1-4-0 1-3-0 0-1-0
Over/Under Record 1-4-0 1-3-0 0-1-0
Moneyline Favorite Record 2-1 1-1 1-0
Moneyline Underdog Record 0-1 0-1 0-0

Players to Watch


  • With 16 tackles and three interceptions in six games, Cam Allen has been a big piece of the Boilermakers’ defense in 2022.
  • Khordae Sydnor has helped carry the Boilermakers’ defense with 3.0 sacks to go along with 4.0 TFL and nine tackles in six games.
  • With 16 tackles, 2.0 TFL, and one interception in six games, Jacob Wahlberg has been a significant part of the Boilermakers’ defense in 2022.
  • Kydran Jenkins, as part of the Boilermakers’ defense, has totaled 2.5 sacks to go with 2.0 TFL and seven tackles in six games.


  • Garrett Nelson has been causing chaos on defense, recording 26 tackles, 3.0 TFL, and 4.5 sacks for the Cornhuskers.
  • Luke Reimer has posted 38 tackles, 2.0 TFL, one sack, and one interception in six games for the Cornhuskers.
  • In six games for the Cornhuskers, Marques Buford Jr. has registered 27 tackles, 2.0 TFL, and two interceptions.
  • With 29 tackles and 3.0 TFL in six games, Isaac Gifford has been wreaking havoc on defense for the Cornhuskers.

Purdue vs. Nebraska Predictions and Pick

Purdue vs. Nebraska betting card

    Pick ATS:

    Boilermakers (-14)

    Pick OU:

    Under (56.5)

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How to Bet on Purdue vs. Nebraska

You can bet on Purdue vs. Nebraska at every legal online sportsbook. For more college football odds, including moneylines, spreads, over/under totals as well as college football prop odds, check out the latest college football lines as well as our guide to the best college football betting sites.

And if you wanted to check out how much you could win on a $10 bet if you parlayed today’s Purdue vs. Nebraska picks, don’t forget to check out our free parlay calculator.

Not sure what a parlay is? Or even how to bet on college football? Check out our complete guide to sports betting.

Our pick to win this matchup is Purdue, and we predict that Purdue will cover the spread (Purdue -14). Finally, we see the scoring in this one going under the posted total of 56.5 points.


Matt Rooney

Matt comes from Chicago and has lived in the area his whole life. Graduated from and played football at Illinois Wesleyan University in Bloomington, IL while also serving as the director of student sports broadcasting. He writes for Betsperts as well as appears on several shows across the network.

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