Penn State vs. Northwestern Prediction: Picks & Start Time – October 2022

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The No. 11 Penn State Nittany Lions (4-0) face a Big Ten matchup with the Northwestern Wildcats (1-3).

Penn State vs. Northwestern Odds

Point Spread

The spread for this matchup is set at 25 points, with oddsmakers listing Penn State as the favorites.


As for the moneyline, Penn State has -7033 odds to pick up the win, while Northwestern is listed at +1455 to claim victory.


Finally, the over/under for the game is set at 50.5 points.

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Game Info

How to Watch Penn State vs. Northwestern Live?

  • Game Day: Saturday, October 1, 2022
  • Game Time: 3:30 PM ET
  • TV Channel: ESPN
  • Location: University Park, Pennsylvania
  • Stadium: Beaver Stadium

Betting Preview

Penn State

Penn State is totaling 464.5 yards per game offensively this year (33rd in the FBS), and are surrendering 366.8 yards per game (65th) on the other side of the ball. Penn State ranks 29th in points scored this season (38.8 points per game), but has been thriving on defense, ranking 23rd-best in the FBS with 16.8 points allowed per game. Penn State has the 35th-ranked passing offense this season (278.8 passing yards per game), and has been worse on the other side of the ball, ranking 23rd-worst with 272.8 passing yards allowed per game. Penn State ranks 44th in rushing yards this season (185.8 rushing yards per game), but has been shining on the defensive side of the ball, ranking 22nd-best in the FBS with 94.0 rushing yards allowed per game. Penn State ranks 88th in third-down efficiency (36.0%) on offense and 38th in third-down percentage allowed (31.7%) on defense this year. With nine forced turnovers (11th in the FBS) against one turnover committed (second in the FBS), Penn State’s +8 turnover margin is the fourth-best in college football.


In terms of total yards, Northwestern ranks 47th in the FBS (445.8 total yards per game) and 83rd on defense (390.3 total yards allowed per game). Northwestern is accumulating 23.0 points per contest on offense this season (104th-ranked). Meanwhile, it is giving up 26.8 points per game (81st-ranked) on defense. Northwestern’s pass offense has been consistently moving the chains, racking up 304.8 passing yards per contest (20th-best) this season. Defensively, it ranks 74th by giving up 229.5 passing yards per game. Northwestern is posting 141.0 rushing yards per game on offense this season (88th-ranked). Meanwhile, it is surrendering 160.8 rushing yards per contest (90th-ranked) on defense. From an offensive perspective, Northwestern is putting up a 37.3% third-down conversion rate (82nd-ranked). It ranks 87th in the FBS on defense (40.4% third-down rate allowed). With five forced turnovers (81st in the FBS) and 10 turnovers committed (118th in the FBS) this season, Northwestern ranks 100th in the FBS with a turnover margin of -5.

Penn State vs. Northwestern Betting Analysis

Penn State Betting Insights

Penn State has put together a record of 3-1-0 against the spread this season. Penn State has an ATS record of 1-1 when playing as at least 25-point favorites. This season, three Penn State games have gone over the point total. The Nittany Lions have not yet lost a game they were the moneyline favorite this season, going 4-0. The Nittany Lions have yet to play as a moneyline favorite of -7033 or shorter.

Wildcats Betting Insights

Northwestern has not won a game against the spread this season (0-3-0). Northwestern games have yet to go over the total once this season. The Wildcats will play as the underdog for the first time this season. The Wildcats have not entered a game this season as a bigger underdog on the moneyline than the +1455 odds on them winning this game.

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Penn State vs. Northwestern Against The Spread & Betting Records

Penn State

Overall Home Away
Point Total AVG 54.4 58.3 50.5
Implied Total AVG 35.3 43.5 27.0
ATS Record 3-1-0 1-1-0 2-0-0
Over/Under Record 3-1-0 1-1-0 2-0-0
Moneyline Favorite Record 4-0 2-0 2-0
Moneyline Underdog Record 0-0 0-0 0-0


Overall Home Away
Point Total AVG 55.0 55.0
Implied Total AVG 33.0 33.0
ATS Record 0-3-0 0-3-0 0-0-0
Over/Under Record 0-3-0 0-3-0 0-0-0
Moneyline Favorite Record 0-3 0-3 0-0
Moneyline Underdog Record 0-0 0-0 0-0

Players to Watch

Penn State

  • Ji’Ayir Brown has hit the gridiron for four games, collecting 1.0 sack to go with 17 tackles and one interception for the Nittany Lions.
  • The Nittany Lions’ defense has been aided by the play of John Dixon, who has suited up for four games and amassed 2.0 sacks to go with 3.0 TFL, seven tackles, and one interception.
  • As part of the Nittany Lions’ defense, Dani Dennis-Sutton has delivered five tackles, 3.0 TFL, and three sacks in four games.
  • With nine tackles and two interceptions, Zakee Wheatley has helped lead the Nittany Lions’ defense over four games.


  • On defense, Bryce Gallagher has helped keep opposing offenses in check with 34 tackles and 2.0 TFL in four games.
  • The Wildcats’ Xander Mueller has compiled 1.0 sack to go with 3.0 TFL, 16 tackles, and two interceptions in four games.
  • Adetomiwa Adebawore has 2.0 sacks to go with 2.0 TFL and 11 tackles in four games.
  • On defense, Coco Azema has compiled 18 tackles, 2.0 TFL, and one sack in four games.

Penn State vs. Northwestern Predictions and Pick

Penn State vs. Northwestern betting card

    Pick ATS:

    Nittany Lions (-25)

    Pick OU:

    Over (50.5)

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How to Bet on Penn State vs. Northwestern

You can bet on Penn State vs. Northwestern at every legal online sportsbook. For more college football odds, including moneylines, spreads, over/under totals as well as college football prop odds, check out the latest college football lines as well as our guide to the best college football betting sites.

And if you wanted to check out how much you could win on a $10 bet if you parlayed today’s Penn State vs. Northwestern picks, don’t forget to check out our free parlay calculator.

Not sure what a parlay is? Or even how to bet on college football? Check out our complete guide to sports betting.

Our prediction to win this contest is Penn State, and we predict that Penn State will cover the spread (Penn State -25). Finally, we see the scoring in this one going over the posted total of 50.5 points.


Dan Weiner

Hailing from Atlanta and attending college at the University of Texas, Dan is passionate about sports, particularly college football and soccer. He's a diehard Atlanta pro sports and Texas Longhorns fan. He likes every sport and will watch anything and everything the weirder the better. He joined Betsperts after an 11 year career in television production at ESPN.

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