Michigan vs. Indiana Prediction: Picks & Start Time – October 2022

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Big Ten rivals will meet when the No. 4 Michigan Wolverines (5-0) meet the Indiana Hoosiers (3-2).

Michigan vs. Indiana Odds

Point Spread

The spread for this matchup is set at 22.5 points, with oddsmakers listing Michigan as the favorites.


As for the moneyline, Michigan has -2145 odds to pick up the win, while Indiana is listed at +981 to claim victory.


Finally, the total for the game is set at 59 points.

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Game Info

How to Watch Michigan vs. Indiana Live?

  • Game Day: Saturday, October 8, 2022
  • Game Time: 12:00 PM ET
  • TV Channel: FOX
  • Location: Bloomington, Indiana
  • Stadium: Memorial Stadium (Bloomington, IN)

Betting Preview


Defensively, Michigan has been a top-25 unit, ranking sixth-best by allowing only 252.0 yards per game. The offense ranks 32nd (456.6 yards per game). Michigan has been making things happen on both sides of the ball this year, as they rank sixth-best in scoring offense (45.4 points per game) and sixth-best in scoring defense (11.6 points allowed per game). Michigan ranks 79th in passing yards this season (234.8 per game), but has been shining on the defensive side of the ball, ranking 10th-best in the FBS with 157.8 passing yards allowed per game. Michigan has been finding success on both sides of the ball in the running game, ranking 13th-best in rushing offense (221.8 rushing yards per game) and 14th-best in rushing defense (94.2 rushing yards allowed per game). Michigan is putting up a 44.2% third-down percentage offensively this year (44th in the FBS), and is surrendering a 30.4% third-down conversion rate (29th) on the other side of the ball. Michigan ranks 26th in college football with a +4 turnover margin after forcing 6 turnovers (82nd in the FBS) and committing two (fifth in the FBS).


Indiana ranks 83rd in total yards per game (384.0), but it has been less effective defensively, ranking 25th-worst in the FBS with 420.4 total yards surrendered per contest. In terms of points scored Indiana ranks 87th in the FBS (27.2 points per game), and it is 99th defensively (30.4 points allowed per game). Indiana ranks 33rd in passing yards per game (278.8), but it has been less productive defensively, ranking 14th-worst in the FBS with 277.8 passing yards conceded per contest. Indiana’s running game has been struggling, ranking 17th-worst in the FBS with 105.2 rushing yards per game. It has been more productive on defense, giving up 142.6 rushing yards per contest (71st-ranked). Indiana is putting up a 41.6% third-down conversion percentage on offense this season (57th-ranked). Meanwhile, it is giving up a 41.8% third-down rate (92nd-ranked) on defense. Indiana has produced eight forced turnovers (45th in the FBS) and committed nine turnovers (99th in the FBS) this season for a -1 turnover margin that ranks 100th in the FBS.

Michigan vs. Indiana Betting Analysis

Michigan Betting Insights

Michigan has covered the spread three times in five games with a set spread. Michigan has an ATS record of 2-1 when playing as at least 22.5-point favorites. This season, Michigan games have yet to hit the over once. The Wolverines have won all four of the games they have been favored on the moneyline this season. The Wolverines have played as a moneyline favorite of -2145 or shorter in just two games this season, and they won both.

Hoosiers Betting Insights

Indiana has gone 1-4-0 against the spread this year. This season, three Indiana games have gone over the point total. The Hoosiers have lost both games they’ve played as underdogs this season. The Hoosiers have not entered a game this season as a bigger underdog on the moneyline than the +981 odds on them winning this game.

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Michigan vs. Indiana Against The Spread & Betting Records


Overall Home Away
Point Total AVG 58.9 63.1 42.0
Implied Total AVG 45.2 50.0 26.0
ATS Record 3-2-0 2-2-0 1-0-0
Over/Under Record 0-4-1 0-3-1 0-1-0
Moneyline Favorite Record 4-0 3-0 1-0
Moneyline Underdog Record 0-0 0-0 0-0


Overall Home Away
Point Total AVG 55.3 52.7 59.3
Implied Total AVG 33.2 31.7 35.5
ATS Record 1-4-0 1-2-0 0-2-0
Over/Under Record 3-2-0 2-1-0 1-1-0
Moneyline Favorite Record 3-0 3-0 0-0
Moneyline Underdog Record 0-2 0-0 0-2

Players to Watch


  • The Wolverines’ defense has been aided by the play of Mike Morris, who has played five games and collected 10 tackles, 6.0 TFL, and four sacks.
  • The Wolverines’ defense has been helped by the play of Junior Colson, who has suited up for five games and collected 1.0 TFL and 36 tackles.
  • As part of the Wolverines’ defensive unit, Mike Sainristil has totaled 16 tackles, 4.0 TFL, and two sacks in five games.
  • The Wolverines’ defensive unit has been aided by Michael Barrett, who has played five games, posting 1.0 sack to go with 1.0 TFL and 22 tackles.


  • In five games for the Hoosiers, Cam Jones has totaled 1.0 sack to go with 1.0 TFL and 37 tackles.
  • Dasan McCullough has been providing a big boost on defense, compiling 16 tackles, 4.0 TFL, and four sacks for the Hoosiers.
  • Noah Pierre has 3.0 sacks to go with 2.0 TFL and 11 tackles in five games.
  • On defense, Bryant Fitzgerald has racked up 22 tackles, 0.5 sacks, and one interception in five games.

Michigan vs. Indiana Predictions and Pick

Michigan vs. Indiana betting card

    Pick ATS:

    Hoosiers (+22.5)

    Pick OU:

    Under (59)

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How to Bet on Michigan vs. Indiana

You can bet on Michigan vs. Indiana at every legal online sportsbook. For more college football odds, including moneylines, spreads, over/under totals as well as college football prop odds, check out the latest college football lines as well as our guide to the best college football betting sites.

And if you wanted to check out how much you could win on a $10 bet if you parlayed today’s Michigan vs. Indiana picks, don’t forget to check out our free parlay calculator.

Not sure what a parlay is? Or even how to bet on college football? Check out our complete guide to sports betting.

Our prediction to win this matchup is Michigan, and we project that Indiana will cover the spread (Michigan -22.5). Finally, we see the scoring in this one going under the posted total of 59 points.


Dan Weiner

Hailing from Atlanta and attending college at the University of Texas, Dan is passionate about sports, particularly college football and soccer. He's a diehard Atlanta pro sports and Texas Longhorns fan. He likes every sport and will watch anything and everything the weirder the better. He joined Betsperts after an 11 year career in television production at ESPN.

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