Louisville vs. Pittsburgh Prediction: Picks & Start Time – October 2022

httpscdn.dataskrive.comapiassetFwmJhlqlouisville cardinals vs pittsburgh panthers Betsperts Media & Technology

ACC foes will meet when the Louisville Cardinals (3-3) meet the Pittsburgh Panthers (4-2).

Louisville vs. Pittsburgh Odds

Point Spread

The spread for this matchup is set at 2 points, with sportsbooks listing Louisville as the favorites.


As for the moneyline, Louisville has -127 odds to pick up the win, while Pittsburgh is listed at +104 to claim victory.


Finally, the over/under for the game is set at 55 points.

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Game Info

How to Watch Louisville vs. Pittsburgh Live?

  • Game Day: Saturday, October 22, 2022
  • Game Time: 8:00 PM ET
  • TV Channel: ACC Network
  • Location: Louisville, Kentucky
  • Stadium: Cardinal Stadium

Betting Preview


Louisville is totaling 436.2 yards per game on offense this year (42nd in the FBS), and are giving up 362.3 yards per game (53rd) on the defensive side of the ball. Louisville is compiling 27.7 points per game on offense, which ranks them 76th in the FBS. On defense, the defense ranks 40th, giving up 22.3 points per contest. Louisville is totaling 229.0 passing yards per game offensively this year (79th in the FBS), and is surrendering 227.7 passing yards per game (67th) on the defensive side of the ball. Louisville ranks 52nd in run defense this season (134.7 rushing yards allowed per game), but has been thriving on offense, ranking 22nd-best in the FBS with 207.2 rushing yards per game. Louisville is putting up a 38.6% third-down percentage on offense, which ranks them 78th in the FBS. On defense, the defense ranks 34th, allowing a 33.3% third-down conversion rate. Louisville owns the 60th-ranked turnover margin in college football at +1, forcing 12 turnovers (28th in the FBS) while turning it over 11 times (88th in the FBS).


With 430.5 total yards per game on the offensive side of the ball, Pittsburgh ranks 51st in the FBS in 2022. On defense, it ranks 28th, allowing 337.2 total yards per contest. In terms of points scored Pittsburgh ranks 34th in the FBS (35.0 points per game), and it is 66th defensively (26.2 points allowed per game). From an offensive angle, Pittsburgh is compiling 237.5 passing yards per game (70th-ranked). It ranks 44th in the FBS defensively (211.8 passing yards surrendered per game). With 193.0 rushing yards per game on offense, Pittsburgh ranks 33rd in the FBS. On defense it ranks 40th, surrendering 125.3 rushing yards per game. From an offensive perspective, Pittsburgh is putting up a 39.0% third-down conversion percentage (71st-ranked). It ranks 36th in the FBS on the other side of the ball (33.7% third-down rate allowed). After forcing nine turnovers (69th in the FBS) and turning the ball over eight times (39th in the FBS) this season, Pittsburgh has the 60th-ranked turnover margin of +1.

Louisville vs. Pittsburgh Betting Analysis

Louisville Betting Insights

Louisville has covered the spread three times in six games with a set spread. In games it has played as 2-point favorites or more, Louisville has an ATS record of 1-2. Games involving Louisville have hit the over three times this season. The Cardinals have been the moneyline favorite three total times this season. They’ve finished 1-2 in those games. The Cardinals have a 0-2 record (winning just 33.3% of their games) when playing as a moneyline favorite of -127 or shorter.

Panthers Betting Insights

Pittsburgh has covered the spread two times over six games with a set number. Pittsburgh has yet to cover the spread when playing as at least 2-point underdogs (0-1). This year, four Pittsburgh games have gone over the point total. The Panthers lost the only game they’ve played as the underdog this season. The Panthers have played as an underdog of +104 or more once this season and lost that game.

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Louisville vs. Pittsburgh Against The Spread & Betting Records


Overall Home Away
Point Total AVG 55.8 60.0 53.6
Implied Total AVG 31.7 34.5 30.3
ATS Record 3-3-0 1-1-0 2-2-0
Over/Under Record 3-3-0 1-1-0 2-2-0
Moneyline Favorite Record 1-2 1-0 0-2
Moneyline Underdog Record 2-1 0-1 2-0


Overall Home Away
Point Total AVG 51.5 52.5 46.5
Implied Total AVG 33.7 34.6 29.0
ATS Record 2-4-0 1-4-0 1-0-0
Over/Under Record 4-1-1 3-1-1 1-0-0
Moneyline Favorite Record 4-1 3-1 1-0
Moneyline Underdog Record 0-1 0-1 0-0

Players to Watch


  • With 3.5 sacks to go with 2.0 TFL, 21 tackles, and one interception in six games, Monty Montgomery has been a key piece of the Cardinals’ defense in 2022.
  • YaYa Diaby has helped lead the Cardinals’ defense with 4.0 sacks to go along with 4.0 TFL and 16 tackles in six games.
  • Yasir Abdullah has played six games, amassing 14 tackles, 5.0 TFL, 2.5 sacks, and one interception for the Cardinals.
  • An important part of the Cardinals’ defense, MoMo Sanogo has 24 tackles, 3.0 TFL, and 1.5 sacks in six games.


  • Sirvocea Dennis has totaled 22 tackles, 3.0 TFL, and 3.5 sacks in six games for the Panthers.
  • The Panthers’ Erick Hallett has delivered 1.0 TFL, 13 tackles, and three interceptions in six games.
  • Calijah Kancey has 3.5 sacks to go with 5.0 TFL and 14 tackles in six games.
  • With 22 tackles, 1.0 TFL, and one sack in six games, Bangally Kamara has been doing his part on defense for the Panthers.

Louisville vs. Pittsburgh Predictions and Pick

Louisville vs. Pittsburgh betting card

    Pick ATS:

    Cardinals (-2)

    Pick OU:

    Under (55)

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How to Bet on Louisville vs. Pittsburgh

You can bet on Louisville vs. Pittsburgh at every legal online sportsbook. For more college football odds, including moneylines, spreads, over/under totals as well as college football prop odds, check out the latest college football lines as well as our guide to the best college football betting sites.

And if you wanted to check out how much you could win on a $10 bet if you parlayed today’s Louisville vs. Pittsburgh picks, don’t forget to check out our free parlay calculator.

Not sure what a parlay is? Or even how to bet on college football? Check out our complete guide to sports betting.

Our pick to win this matchup is Louisville, and we expect that Louisville will cover the spread (Louisville -2). Finally, we see the scoring in this one going under the posted total of 55 points.


Dan Weiner

Hailing from Atlanta and attending college at the University of Texas, Dan is passionate about sports, particularly college football and soccer. He's a diehard Atlanta pro sports and Texas Longhorns fan. He likes every sport and will watch anything and everything the weirder the better. He joined Betsperts after an 11 year career in television production at ESPN.

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