ACC foes will meet when the Louisville Cardinals (3-3) meet the Pittsburgh Panthers (4-2).
Louisville vs. Pittsburgh Odds
Point Spread
The spread for this matchup is set at 2 points, with sportsbooks listing Louisville as the favorites.
Moneyline
As for the moneyline, Louisville has -127 odds to pick up the win, while Pittsburgh is listed at +104 to claim victory.
Over/Under
Finally, the over/under for the game is set at 55 points.

Game Info
How to Watch Louisville vs. Pittsburgh Live?
- Game Day: Saturday, October 22, 2022
- Game Time: 8:00 PM ET
- TV Channel: ACC Network
- Location: Louisville, Kentucky
- Stadium: Cardinal Stadium
Betting Preview
Louisville
Louisville is totaling 436.2 yards per game on offense this year (42nd in the FBS), and are giving up 362.3 yards per game (53rd) on the defensive side of the ball. Louisville is compiling 27.7 points per game on offense, which ranks them 76th in the FBS. On defense, the defense ranks 40th, giving up 22.3 points per contest. Louisville is totaling 229.0 passing yards per game offensively this year (79th in the FBS), and is surrendering 227.7 passing yards per game (67th) on the defensive side of the ball. Louisville ranks 52nd in run defense this season (134.7 rushing yards allowed per game), but has been thriving on offense, ranking 22nd-best in the FBS with 207.2 rushing yards per game. Louisville is putting up a 38.6% third-down percentage on offense, which ranks them 78th in the FBS. On defense, the defense ranks 34th, allowing a 33.3% third-down conversion rate. Louisville owns the 60th-ranked turnover margin in college football at +1, forcing 12 turnovers (28th in the FBS) while turning it over 11 times (88th in the FBS).
Pittsburgh
With 430.5 total yards per game on the offensive side of the ball, Pittsburgh ranks 51st in the FBS in 2022. On defense, it ranks 28th, allowing 337.2 total yards per contest. In terms of points scored Pittsburgh ranks 34th in the FBS (35.0 points per game), and it is 66th defensively (26.2 points allowed per game). From an offensive angle, Pittsburgh is compiling 237.5 passing yards per game (70th-ranked). It ranks 44th in the FBS defensively (211.8 passing yards surrendered per game). With 193.0 rushing yards per game on offense, Pittsburgh ranks 33rd in the FBS. On defense it ranks 40th, surrendering 125.3 rushing yards per game. From an offensive perspective, Pittsburgh is putting up a 39.0% third-down conversion percentage (71st-ranked). It ranks 36th in the FBS on the other side of the ball (33.7% third-down rate allowed). After forcing nine turnovers (69th in the FBS) and turning the ball over eight times (39th in the FBS) this season, Pittsburgh has the 60th-ranked turnover margin of +1.
Louisville vs. Pittsburgh Betting Analysis
Louisville Betting Insights
Louisville has covered the spread three times in six games with a set spread. In games it has played as 2-point favorites or more, Louisville has an ATS record of 1-2. Games involving Louisville have hit the over three times this season. The Cardinals have been the moneyline favorite three total times this season. They’ve finished 1-2 in those games. The Cardinals have a 0-2 record (winning just 33.3% of their games) when playing as a moneyline favorite of -127 or shorter.
Panthers Betting Insights
Pittsburgh has covered the spread two times over six games with a set number. Pittsburgh has yet to cover the spread when playing as at least 2-point underdogs (0-1). This year, four Pittsburgh games have gone over the point total. The Panthers lost the only game they’ve played as the underdog this season. The Panthers have played as an underdog of +104 or more once this season and lost that game.

Louisville vs. Pittsburgh Against The Spread & Betting Records
Louisville
Overall | Home | Away | |
---|---|---|---|
Point Total AVG | 55.8 | 60.0 | 53.6 |
Implied Total AVG | 31.7 | 34.5 | 30.3 |
ATS Record | 3-3-0 | 1-1-0 | 2-2-0 |
Over/Under Record | 3-3-0 | 1-1-0 | 2-2-0 |
Moneyline Favorite Record | 1-2 | 1-0 | 0-2 |
Moneyline Underdog Record | 2-1 | 0-1 | 2-0 |
Panthers
Overall | Home | Away | |
---|---|---|---|
Point Total AVG | 51.5 | 52.5 | 46.5 |
Implied Total AVG | 33.7 | 34.6 | 29.0 |
ATS Record | 2-4-0 | 1-4-0 | 1-0-0 |
Over/Under Record | 4-1-1 | 3-1-1 | 1-0-0 |
Moneyline Favorite Record | 4-1 | 3-1 | 1-0 |
Moneyline Underdog Record | 0-1 | 0-1 | 0-0 |
Players to Watch
Louisville
- With 3.5 sacks to go with 2.0 TFL, 21 tackles, and one interception in six games, Monty Montgomery has been a key piece of the Cardinals’ defense in 2022.
- YaYa Diaby has helped lead the Cardinals’ defense with 4.0 sacks to go along with 4.0 TFL and 16 tackles in six games.
- Yasir Abdullah has played six games, amassing 14 tackles, 5.0 TFL, 2.5 sacks, and one interception for the Cardinals.
- An important part of the Cardinals’ defense, MoMo Sanogo has 24 tackles, 3.0 TFL, and 1.5 sacks in six games.
Panthers
- Sirvocea Dennis has totaled 22 tackles, 3.0 TFL, and 3.5 sacks in six games for the Panthers.
- The Panthers’ Erick Hallett has delivered 1.0 TFL, 13 tackles, and three interceptions in six games.
- Calijah Kancey has 3.5 sacks to go with 5.0 TFL and 14 tackles in six games.
- With 22 tackles, 1.0 TFL, and one sack in six games, Bangally Kamara has been doing his part on defense for the Panthers.
Louisville vs. Pittsburgh Predictions and Pick
Louisville vs. Pittsburgh betting card
- Pick ATS:
Cardinals (-2)
Pick OU:
Under (55)

How to Bet on Louisville vs. Pittsburgh
You can bet on Louisville vs. Pittsburgh at every legal online sportsbook. For more college football odds, including moneylines, spreads, over/under totals as well as college football prop odds, check out the latest college football lines as well as our guide to the best college football betting sites.
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Our pick to win this matchup is Louisville, and we expect that Louisville will cover the spread (Louisville -2). Finally, we see the scoring in this one going under the posted total of 55 points.