Louisville vs. Boston College Prediction: Picks & Start Time – October 2022

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The Louisville Cardinals (2-2) face an ACC matchup against the Boston College Eagles (1-3).

Louisville vs. Boston College Odds

Point Spread

The spread for this matchup is set at 13.5 points, with bookmakers listing Louisville as the favorites.


As for the moneyline, Louisville has -559 odds to pick up the win, while Boston College is listed at +394 to claim victory.


Finally, the total for the game is set at 51 points.

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Game Info

How to Watch Louisville vs. Boston College Live?

  • Game Day: Saturday, October 1, 2022
  • Game Time: 12:00 PM ET
  • TV Channel: ACC Network
  • Location: Boston, Massachusetts
  • Stadium: Alumni Stadium

Betting Preview


Louisville is putting up 448.0 yards per game on offense, which ranks 44th in the FBS. Defensively, the Cardinals rank 53rd, allowing 350.3 yards per contest. Louisville is putting up 24.8 points per game on offense this year (95th in the FBS), and is surrendering 20.8 points per game (48th) on the defensive side of the ball. Louisville ranks 85th in pass offense (223.5 passing yards per game) and 31st in pass defense (187.3 passing yards allowed per game) this year. On the offensive side of the ball, Louisville has been a top-25 unit in terms of rushing yards, ranking 14th-best in the FBS by averaging 224.5 per game. The Cardinals rank 93rd on defense (163.0 rushing yards allowed per game). Louisville ranks 22nd-worst in third-down conversion rate (32.7%), but has played better on defense, ranking 64th with a 36.8% third-down conversion rate allowed. With six forced turnovers (56th in the FBS) against eight turnovers committed (100th in the FBS), Louisville’s -2-2 turnover margin ranks 100th in college football.

Boston College

Boston College’s offense has been a bottom-25 unit in total offense this season, compiling 283.3 total yards per game, which ranks 11th-worst in the FBS. On defense, it ranks 73rd with 378.5 total yards allowed per contest. Boston College has not been getting things done on offense, ranking 22nd-worst in the FBS with 20.8 points per game. It has been more productive on the other side of the ball, surrendering 27.5 points per contest (86th-ranked). Boston College ranks 85th in the FBS with 223.5 passing yards per contest on offense, and it ranks 68th with 222.3 passing yards ceded per contest on defense. Boston College’s rushing offense has been bottom-25 this season, registering 59.8 rushing yards per game, which ranks fourth-worst in the FBS. On the defensive side of the ball, it ranks 84th with 156.3 rushing yards conceded per contest. Boston College’s offense has been sputtering on third down, ranking 24th-worst in the FBS with a 32.8% third-down conversion percentage. It has been better defensively, giving up a 34.5% third-down rate (53rd-ranked). Boston College has registered four forced turnovers (99th in the FBS) and committed six turnovers (68th in the FBS) this season for a -2 turnover margin that ranks 100th in the FBS.

Louisville vs. Boston College Betting Analysis

Louisville Betting Insights

Louisville has covered the spread twice in four games with a set spread. Louisville is a perfect 1-0 ATS when playing as at least 13.5-point favorites. Games involving Louisville have hit the over once this season. The Cardinals have been the moneyline favorite just two other times so far this season, and they split the two games. The Cardinals have played as a moneyline favorite of -559 or shorter in just one game this season, which they won.

Eagles Betting Insights

Boston College has not covered the spread this year (0-4-0). Boston College has not covered the spread (0-1) when it is at least 13.5-point underdogs. Boston College games have gone over the total twice this season. The Eagles have lost both games they’ve played as underdogs this season. The Eagles have a record of 0-1 when they’re set as an underdog of +394 or more by bookmakers this season.

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Louisville vs. Boston College Against The Spread & Betting Records


Overall Home Away
Point Total AVG 59.5 60.0 59.0
Implied Total AVG 33.5 34.5 32.5
ATS Record 2-2-0 1-1-0 1-1-0
Over/Under Record 1-3-0 1-1-0 0-2-0
Moneyline Favorite Record 1-1 1-0 0-1
Moneyline Underdog Record 1-1 0-1 1-0


Overall Home Away
Point Total AVG 47.9 48.5 47.3
Implied Total AVG 31.8 34.5 29.0
ATS Record 0-4-0 0-2-0 0-2-0
Over/Under Record 2-2-0 1-1-0 1-1-0
Moneyline Favorite Record 0-1 0-1 0-0
Moneyline Underdog Record 0-2 0-0 0-2

Players to Watch


  • The Cardinals’ defense has been aided by the play of YaYa Diaby, who has suited up for four games and amassed 14 tackles, 4.0 TFL, and four sacks.
  • Yasir Abdullah has helped carry the Cardinals’ defense with 1.5 sacks to go along with 4.0 TFL, 13 tackles, and one interception in four games.
  • With 24 tackles in four games, Kenderick Duncan Jr. has been a key part of the Cardinals’ defense in 2022.
  • Benjamin Perry has been an important piece of the Cardinals’ defense in 2022, with 19 tackles and 1.0 TFL in four games.


  • As a key defensive contributor, the Eagles’ Donovan Ezeiruaku has collected 15 tackles, 1.0 TFL, and two sacks in four games.
  • The Eagles’ Jaylen Blackwell has amassed 2.0 sacks to go with 3.0 TFL and 11 tackles in four games.
  • Vinny DePalma has been wreaking havoc on defense, posting 2.0 TFL and 14 tackles for the Eagles.
  • With one interception to go with 17 tackles and one pass defended in four games, Kam Arnold has been making a big difference on defense for the Eagles.

Louisville vs. Boston College Predictions and Pick

Louisville vs. Boston College betting card

    Pick ATS:

    Cardinals (-13.5)

    Pick OU:

    Under (51)

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How to Bet on Louisville vs. Boston College

You can bet on Louisville vs. Boston College at every legal online sportsbook. For more college football odds, including moneylines, spreads, over/under totals as well as college football prop odds, check out the latest college football lines as well as our guide to the best college football betting sites.

And if you wanted to check out how much you could win on a $10 bet if you parlayed today’s Louisville vs. Boston College picks, don’t forget to check out our free parlay calculator.

Not sure what a parlay is? Or even how to bet on college football? Check out our complete guide to sports betting.

Our pick to win this game is Louisville, and we predict that Louisville will cover the spread (Louisville -13.5). Finally, we see the scoring in this one going under the posted total of 51 points.


Matt Rooney

Matt comes from Chicago and has lived in the area his whole life. Graduated from and played football at Illinois Wesleyan University in Bloomington, IL while also serving as the director of student sports broadcasting. He writes for Betsperts as well as appears on several shows across the network.

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