Kentucky vs. Louisville Prediction: Picks & Start Time – November 26, 2022

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The Kentucky Wildcats (6-5) and Louisville Cardinals (7-4) will clash in a matchup at Kroger Field in Lexington, Kentucky.

Kentucky vs. Louisville Odds

Point Spread

The spread for this matchup is set at 3 points, with bookmakers listing Kentucky as the favorites.


As for the moneyline, Kentucky has -159 odds to pick up the win, while Louisville is listed at +130 to claim victory.


Finally, the over/under for the game is set at 42.5 points.

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Game Info

How to Watch Kentucky vs. Louisville Live?

  • Game Day: Saturday, November 26, 2022
  • Game Time: 3:00 PM ET
  • TV Channel: SEC Network
  • Location: Lexington, Kentucky
  • Stadium: Kroger Field

Betting Preview


Kentucky has struggled on offense, ranking 25th-worst in the FBS (335.5 yards per game) this season. However, the defense ranks 19th-best in the nation, giving up only 321.2 yards per game. Kentucky sports the 106th-ranked offense this season (21.7 points per game), and has been more effective on the other side of the ball, ranking 17th-best with only 19.6 points allowed per game. Kentucky has the 82nd-ranked offense this season in terms of passing yards (218.6 passing yards per game), and has been more effective defensively, ranking 12th-best with only 176.0 passing yards allowed per game. While Kentucky’s run defense ranks 62nd with 145.2 rushing yards allowed per game, the offense has been worse, ranking 25th-worst (116.8 rushing yards per game). Kentucky is putting up a 37.6% third-down percentage on offense (84th in the FBS), and ranks 44th on the other side of the ball with a 35.8% third-down percentage allowed. Kentucky owns the 100th-ranked turnover margin in college football at -4, forcing 13 turnovers (92nd in the FBS) while turning it over 17 times (74th in the FBS).

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From an offensive angle, Louisville is accumulating 413.7 total yards per game (47th-ranked). It ranks 38th in the FBS on the other side of the ball (347.7 total yards given up per game). Louisville has been excelling on defense, allowing only 19.6 points per contest (17th-best). Offensively, it ranks 68th by posting 28.5 points per game. From an offensive standpoint, Louisville is compiling 217.2 passing yards per game (88th-ranked). It ranks 42nd in the FBS on defense (208.3 passing yards surrendered per game). In terms of rushing, Louisville ranks 28th in the FBS on offense (196.5 rushing yards per game) and 51st defensively (139.5 rushing yards allowed per contest). Louisville is putting up a 36.4% third-down conversion percentage on offense this season (92nd-ranked). Meanwhile, it is surrendering a 34.7% third-down rate (37th-ranked) on defense. Louisville has a top-25 turnover margin this season, ranking fourth-best at +12.

Kentucky vs. Louisville Betting Analysis

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Kentucky Betting Insights

Kentucky has covered the spread seven times in 11 games with a set spread. Kentucky is 2-3 ATS when playing as at least 3-point favorites. Kentucky games have gone over the total once this season. The Wildcats have gone 3-2 in games they were favored on the moneyline (winning 60% of those games). The Wildcats have a 0-2 record (winning 60% of their games) when playing as a moneyline favorite of -159 or shorter.

Cardinals Betting Insights

Louisville have registered a 7-4-0 record against the spread this season. In games they have played as 3-point or bigger underdogs, Louisville owns an ATS record of 2-1. This year, Louisville games have hit the over four times. The Cardinals have entered the game as underdogs five times this season and won three of those games. The Cardinals have entered two games this season as the underdog by +130 or more and are 0-1 in those contests.

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Kentucky vs. Louisville Against The Spread & Betting Records


Overall Home Away
Point Total AVG 50.5 49.4 52.5
Implied Total AVG 31.7 33.3 29.0
ATS Record 7-4-0 4-3-0 3-1-0
Over/Under Record 1-10-0 1-6-0 0-4-0
Moneyline Favorite Record 3-2 3-2 0-0
Moneyline Underdog Record 3-3 1-1 2-2


Overall Home Away
Point Total AVG 54.9 56.3 53.3
Implied Total AVG 30.6 31.0 30.2
ATS Record 7-4-0 5-1-0 2-3-0
Over/Under Record 4-7-0 2-4-0 2-3-0
Moneyline Favorite Record 4-2 4-0 0-2
Moneyline Underdog Record 3-2 1-1 2-1

Players to Watch


  • The Wildcats’ defensive unit has been aided by the contributions of J.J. Weaver, who has suited up for 11 games and compiled 34 tackles, 3.0 TFL, and two sacks.
  • The Wildcats’ defense has been helped by the play of Carrington Valentine, who has suited up for 11 games and posted 1.0 sack to go with 1.0 TFL, 34 tackles, and one interception.
  • Jordan Wright has helped lead the Wildcats’ defense with one interception to go along with 33 tackles, 4.0 TFL, one sack, and one pass defended in 11 games.
  • With 1.0 TFL, 32 tackles, and two interceptions, Keidron Smith has helped propel the Wildcats’ defense over 11 games.


  • Yasir Abdullah has been providing a big boost on defense, delivering two interceptions to go with 40 tackles, 8.0 TFL, eight sacks, and two passes defended for the Cardinals.
  • Monty Montgomery has been causing chaos on defense, collecting two interceptions to go with 42 tackles, 4.0 TFL, five sacks, and two passes defended for the Cardinals.
  • MoMo Sanogo has 3.5 sacks to go with 6.0 TFL and 58 tackles in 11 games.
  • YaYa Diaby has delivered 5.5 sacks to go with 7.0 TFL and 24 tackles in 11 games for the Cardinals.

Kentucky vs. Louisville Predictions and Pick

Kentucky vs. Louisville betting card

    Pick ATS:

    Cardinals (+3)

    Pick OU:

    Over (42.5)

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How to Bet on Kentucky vs. Louisville

You can bet on Kentucky vs. Louisville at every legal online sportsbook. For more college football odds, including moneylines, spreads, over/under totals as well as college football prop odds, check out the latest college football lines as well as our guide to the best college football betting sites.

And if you wanted to check out how much you could win on a $10 bet if you parlayed today’s Kentucky vs. Louisville picks, don’t forget to check out our free parlay calculator.

Not sure what a parlay is? Or even how to bet on college football? Check out our complete guide to sports betting.

Our prediction to win this game is Louisville, and we predict that Louisville will cover the spread (Kentucky -3). Finally, we see the scoring in this one going over the posted total of 42.5 points.


Dan Weiner

Hailing from Atlanta and attending college at the University of Texas, Dan is passionate about sports, particularly college football and soccer. He's a diehard Atlanta pro sports and Texas Longhorns fan. He likes every sport and will watch anything and everything the weirder the better. He joined Betsperts after an 11 year career in television production at ESPN.

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