Iowa State vs. Ohio Prediction: Picks & Start Time – September 17

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The Iowa State Cyclones (2-0) hit the field against the Ohio Bobcats (1-1) in college football action at Jack Trice Stadium in Ames, Iowa.

Iowa State vs. Ohio Odds

Point Spread

The spread for this matchup is set at 18.5 points, with sportsbooks listing Iowa State as the favorites.


As for the moneyline, Iowa State has -1181 odds to pick up the win, while Ohio is listed at +699 to claim victory.


Finally, the over/under for the game is set at 47.5 points.


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Game Info

How to Watch Iowa State vs. Ohio Live?

  • Game Day: Saturday, September 17, 2022
  • Game Time: 2:00 PM ET
  • TV Channel: ESPN+
  • Location: Ames, Iowa
  • Stadium: Jack Trice Stadium

Betting Preview

Iowa State

  • Iowa State racked up just 1.0 more point per game (31.3) than Ohio surrendered (30.3) last year.
  • The Cyclones were 4-2 against the spread and 4-2 overall in games when they scored over 30.3 points last season.
  • Iowa State collected just 5.3 fewer yards per game (424.5) than Ohio allowed per matchup (429.8) last season.
  • The Cyclones were 4-2 against the spread and 4-2 overall when the team picked up more than 429.8 yards last season.
  • Last year Iowa State averaged 160.7 yards per game on the ground, 29.5 fewer than Ohio allowed per outing (190.2).
  • When the Cyclones ran for over 190.2 yards last season, they compiled a 3-2 ATS record and a 3-2 overall record.


  • Last season Ohio put up just 2.1 more points per game (22.6) than Iowa State allowed (20.5).
  • The Bobcats were 5-3 against the spread and 3-5 overall last year when the team recorded more than 20.5 points.
  • Ohio averaged 61.2 more yards per game (371.4) than Iowa State gave up per contest (310.2) last season.
  • The Bobcats were 5-4 against the spread and 3-6 overall when the team piled up more than 310.2 yards last season.
  • Ohio rushed for 187.4 yards per game last year, 65.4 more than the 122.0 Iowa State allowed per contest.
  • Last year the Bobcats had a 5-5 ATS record and a 3-7 overall record in games the team rushed for over 122.0 yards.

Iowa State vs. Ohio Betting Analysis

Iowa State Betting Insights

  • Iowa State was 5-8-0 against the spread last season.
  • Iowa State had two wins ATS (2-1) as 18.5-point or greater favorites last season.
  • The Cyclones went 7-4 in games they were favored on the moneyline last season (winning 63.6% of those games).
  • The Cyclones won all three games they played as a moneyline favorite with odds of -1181 or shorter.
  • Last year, six of Iowa State’s 13 games hit the over.

Bobcats Betting Insights

  • Ohio’s record against the spread last season was 5-7-0.
  • Ohio had no wins ATS (0-1) as underdogs of 18.5 points or more last season.
  • The Bobcats were underdogs in eight games last season and won two (25%) of those contests.
  • Last season, the Bobcats were at least a +699 underdog on the moneyline two times, losing each of those contests.
  • Out of 12 Ohio games last year, four hit the over.

Iowa State vs. Ohio Against The Spread & Betting Records

Iowa State

Overall Home Away
Point Total AVG 52.1 52.1 52.2
Implied Total AVG 32.7 33.3 32.0
ATS Record 5-8-0 3-4-0 2-4-0
Over/Under Record 6-7-0 2-5-0 4-2-0
Moneyline Favorite Record 7-4 5-1 2-3
Moneyline Underdog Record 0-2 0-1 0-1


Overall Home Away
Point Total AVG 55.5 57.0 54.0
Implied Total AVG 32.8 33.3 32.3
ATS Record 5-7-0 2-4-0 3-3-0
Over/Under Record 4-8-0 3-3-0 1-5-0
Moneyline Favorite Record 1-2 0-1 1-1
Moneyline Underdog Record 2-6 1-3 1-3

Last Season’s Leaders

Iowa State

  • As a tone-setter on defense, Will McDonald IV totaled 35 tackles, 6.0 TFL, and 11.5 sacks in 13 games last year.
  • Jake Hummel delivered 77 tackles, 6.0 TFL, one sack, and two interceptions in 13 games.
  • Eyioma Uwazurike registered 9.0 sacks to go with 10.0 TFL and 42 tackles in 13 games played a season ago.
  • On defense in 2021, Mike Rose piled up 70 tackles, 9.0 TFL, and three sacks through 13 games.


  • On defense Bryce Houston, who played in 12 games, amassed 78 tackles, 5.0 TFL, and 1.5 sacks.
  • Cannon Blauser, who was on the field for 12 games, amassed 2.0 sacks to go with 5.0 TFL and 60 tackles.
  • Alvin Floyd helped on defense with one interception to go along with 46 tackles, 2.0 TFL, and one pass defended in 12 games.
  • Will Evans collected 3.5 sacks to go with 3.0 TFL and 27 tackles in 12 games.

Iowa State vs. Ohio Predictions and Pick

Iowa State vs. Ohio betting card

    Pick ATS:

    Cyclones (-18.5)

    Pick OU:

    Over (47.5)

How to Bet on Iowa State vs. Ohio

You can bet on Iowa State vs. Ohio at every legal online sportsbook. For more college football odds, including moneylines, spreads, over/under totals as well as college football prop odds, check out the latest college football lines as well as our guide to the best college football betting sites.

And if you wanted to check out how much you could win on a $10 bet if you parlayed today’s Iowa State vs. Ohio picks, don’t forget to check out our free parlay calculator.

Not sure what a parlay is? Or even how to bet on college football? Check out our complete guide to sports betting.

Our pick to win this matchup is Iowa State, and we expect that Iowa State will cover the spread (Iowa State -18.5). Finally, we see the scoring in this one going over the posted total of 47.5 points.


Matt Rooney

Matt comes from Chicago and has lived in the area his whole life. Graduated from and played football at Illinois Wesleyan University in Bloomington, IL while also serving as the director of student sports broadcasting. He writes for Betsperts as well as appears on several shows across the network.

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