Clemson vs. Wake Forest Prediction: Picks & Start Time – September 2022

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ACC foes will do battle when the No. 5 Clemson Tigers (3-0) battle the No. 21 Wake Forest Demon Deacons (3-0) at Truist Field in Winston-Salem, North Carolina.

Clemson vs. Wake Forest Odds

Point Spread

The spread for this matchup is set at 7.5 points, with oddsmakers listing Clemson as the favorites.


As for the moneyline, Clemson has -289 odds to pick up the win, while Wake Forest is listed at +227 to claim victory.


Finally, the total for the game is set at 55.5 points.

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Game Info

How to Watch Clemson vs. Wake Forest Live?

  • Game Day: Saturday, September 24, 2022
  • Game Time: 12:00 PM ET
  • TV Channel: ABC
  • Location: Winston-Salem, North Carolina
  • Stadium: Truist Field

Betting Preview


Clemson ranks 61st in total offense (427.7 yards per game) and 36th in total defense (312.7 yards allowed per game) this season. Clemson has been a handful for opposing teams, as they rank top-25 in both scoring offense (25th-best with 41.3 points per game) and scoring defense (20th-best with 14.0 points allowed per game) this year. Clemson ranks 75th in pass offense (243.0 passing yards per game) and 87th in pass defense (243.7 passing yards allowed per game) this season. Clemson has the 57th-ranked offense this year in terms of rushing yards (184.7 per game), and has been more effective on the other side of the ball, ranking seventh-best with only 69.0 rushing yards allowed per game. Clemson is putting up a 46.3% third-down conversion rate on offense (43rd in the FBS), and ranks 59th on defense with a 34.7% third-down conversion rate allowed. Clemson has the 35th-ranked turnover margin in college football at +2, forcing six turnovers (25th in the FBS) while turning it over four times (49th in the FBS).

Wake Forest

With 435.7 total yards per game on the offensive side of the ball, Wake Forest ranks 56th in the FBS in 2022. On defense, it ranks 39th, allowing 316.3 total yards per contest. Wake Forest’s offense has been excelling, putting up 42.0 points per contest (21st-best) this season. Defensively, it ranks 62nd by allowing 23.7 points per game. Wake Forest’s pass defense ranks 38th in the FBS with 192.0 passing yards allowed per contest, but it has been bolstered by its offense, which ranks 23rd-best by compiling 306.3 passing yards per game. In terms of rushing, Wake Forest ranks 96th in the FBS on offense (129.3 rushing yards per game) and 53rd on the other side of the ball (124.3 rushing yards allowed per contest). Wake Forest ranks 65th in the FBS with a 40.0% third-down conversion rate, but it has been carried by its defense, which ranks sixth-best by surrendering a 21.3% third-down rate. Wake Forest has a top-25 turnover margin this season, ranking 10th-best at +5.

Clemson vs. Wake Forest Betting Analysis

Clemson Betting Insights

Clemson is 1-2-0 against the spread this season. Clemson has 1-2 ATS when playing as at least 7.5-point favorites. Games involving Clemson have hit the over once this season. The Tigers have been the moneyline favorite only two other times so far this season, and they won both of the games. The Tigers have played as a moneyline favorite of -289 or shorter in only two games this season, and they won both.

Demon Deacons Betting Insights

Wake Forest has put together a record of 1-1-1 against the spread this season. This season, Wake Forest games have hit the over twice. The Demon Deacons have not played a game this season while listed as the underdog. The Demon Deacons have played as an underdog of +227 or more once this season and won that game.

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Clemson vs. Wake Forest Against The Spread & Betting Records


Overall Home Away
Point Total AVG 55.2 56.8 52.0
Implied Total AVG 45.0 48.5 38.0
ATS Record 1-2-0 0-2-0 1-0-0
Over/Under Record 1-2-0 1-1-0 0-1-0
Moneyline Favorite Record 2-0 1-0 1-0
Moneyline Underdog Record 0-0 0-0 0-0

Demon Deacons

Overall Home Away
Point Total AVG 65.0 65.0 65.0
Implied Total AVG 43.0 45.0 39.0
ATS Record 1-1-1 0-1-1 1-0-0
Over/Under Record 2-1-0 1-1-0 1-0-0
Moneyline Favorite Record 2-0 1-0 1-0
Moneyline Underdog Record 0-0 0-0 0-0

Players to Watch


  • Barrett Carter has helped spur the Tigers’ defense with 12 tackles, 1.0 TFL, and one interception in three games.
  • With nine tackles, 1.0 TFL, and one sack in three games, K.J. Henry has been a key piece of the Tigers’ defense in 2022.
  • Jeremiah Trotter Jr. has suited up for three games, posting six tackles, 1.0 TFL, one sack, and one interception for the Tigers.
  • The Tigers’ defensive unit has been helped by LaVonta Bentley, who has played three games, recording 1.0 sack to go with 2.0 TFL and nine tackles.

Demon Deacons

  • As a playmaker on defense, the Demon Deacons’ Rondell Bothroyd has posted four tackles, 1.0 TFL, and two sacks in three games.
  • The Demon Deacons’ Kobie Turner has recorded 1.0 sack to go with 1.0 TFL and seven tackles in three games.
  • In three games for the Demon Deacons, Malik Mustapha has delivered four tackles, 1.0 TFL, and two sacks.
  • JaCorey Johns has delivered 1.0 sack to go with 1.0 TFL and five tackles in three games for the Demon Deacons.

Clemson vs. Wake Forest Predictions and Pick

Clemson vs. Wake Forest betting card

    Pick ATS:

    Demon Deacons (+7.5)

    Pick OU:

    Over (55.5)

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How to Bet on Clemson vs. Wake Forest

You can bet on Clemson vs. Wake Forest at every legal online sportsbook. For more college football odds, including moneylines, spreads, over/under totals as well as college football prop odds, check out the latest college football lines as well as our guide to the best college football betting sites.

And if you wanted to check out how much you could win on a $10 bet if you parlayed today’s Clemson vs. Wake Forest picks, don’t forget to check out our free parlay calculator.

Not sure what a parlay is? Or even how to bet on college football? Check out our complete guide to sports betting.

Our prediction to win this contest is Wake Forest, and we predict that Wake Forest will cover the spread (Clemson -7.5). Finally, we see the scoring in this one going over the posted total of 55.5 points.


Matt Rooney

Matt comes from Chicago and has lived in the area his whole life. Graduated from and played football at Illinois Wesleyan University in Bloomington, IL while also serving as the director of student sports broadcasting. He writes for Betsperts as well as appears on several shows across the network.

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