Clemson vs. Syracuse Prediction: Picks & Start Time – October 2022

httpscdn.dataskrive.comapiassetZI4rPbNclemson tigers vs syracuse orange Betsperts Media & Technology

ACC opponents will do battle when the No. 5 Clemson Tigers (7-0) face the No. 14 Syracuse Orange (6-0) at Memorial Stadium in Berkeley, California.

Clemson vs. Syracuse Odds

Point Spread

The spread for this matchup is set at 14 points, with oddsmakers listing Clemson as the favorites.


As for the moneyline, Clemson has -636 odds to pick up the win, while Syracuse is listed at +428 to claim victory.


Finally, the total for the game is set at 49.5 points.

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Game Info

How to Watch Clemson vs. Syracuse Live?

  • Game Day: Saturday, October 22, 2022
  • Game Time: 12:00 PM ET
  • TV Channel: ABC
  • Location: Berkeley, California
  • Stadium: Memorial Stadium

Betting Preview


On offense, Clemson ranks 59th in the FBS with 418.6 yards per game. Meanwhile, its defense ranks 31st in total defense (339.7 yards allowed per contest). Clemson owns the 26th-ranked defense this season (19.7 points allowed per game), and has been more effective on offense, ranking 21st-best with 38.6 points per game. Clemson is totaling 247.4 passing yards per game offensively this season (63rd in the FBS), and is giving up 255.3 passing yards per game (96th) on defense. Clemson ranks 52nd in rushing yards this year (171.1 rushing yards per game), but has been thriving on the defensive side of the ball, ranking fifth-best in the FBS with 84.4 rushing yards allowed per game. Clemson sports the 59th-ranked defense this year in terms of third-down efficiency (36.8% third-down conversion rate allowed), and has been better on offense, ranking 14th-best with a 50.5% third-down percentage. With 10 forced turnovers (55th in the FBS) against five turnovers committed (11th in the FBS), Clemson’s +5 turnover margin is the 22nd-best in college football.


Syracuse’s defense has been leading the charge for the team, as it ranks eighth-best in the FBS with 268.8 total yards allowed per game. In terms of offense, it is putting up 432.0 total yards per game, which ranks 47th. Syracuse ranks 30th in the FBS with 36.0 points per contest, but it has been lifted up by its defense, which ranks sixth-best by giving up just 13.2 points per game. Syracuse’s pass defense has been leading the way for the team, as it ranks 12th-best in the FBS with 173.8 passing yards surrendered per game. In terms of offense, it is compiling 243.7 passing yards per game, which ranks 65th. Syracuse’s run defense has been leading the way for the team, as it ranks 11th-best in the FBS with 95.0 rushing yards surrendered per contest. In terms of offense, it is putting up 188.3 rushing yards per game, which ranks 37th. In terms of third-down efficiency, Syracuse ranks 30th in the FBS (46.3% third-down conversion percentage) and 58th on defense (36.7% third-down rate allowed). Syracuse has recorded nine forced turnovers (69th in the FBS) and committed six turnovers (19th in the FBS) this season for a +3 turnover margin that ranks 34th in the FBS.

Clemson vs. Syracuse Betting Analysis

Clemson Betting Insights

Clemson is 4-3-0 against the spread this season. Clemson has an ATS record of 2-2 when playing as at least 14-point favorites. Clemson games have finished with a final combined score above the over/under four times this season. The Tigers have been the moneyline favorite a total of six times this season, and they’ve won all of those games. The Tigers have played in three games as a moneyline favorite with odds of -636 or shorter and won every time.

Orange Betting Insights

Syracuse have compiled a 5-1-0 record against the spread this season. Games involving Syracuse have hit the over twice this season. The Orange won the only game they’ve played as the underdog this season. The Orange have played as an underdog of +428 or more once this season and won that game.

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Clemson vs. Syracuse Against The Spread & Betting Records


Overall Home Away
Point Total AVG 52.7 53.0 52.5
Implied Total AVG 36.7 41.0 33.5
ATS Record 4-3-0 1-2-0 3-1-0
Over/Under Record 4-3-0 2-1-0 2-2-0
Moneyline Favorite Record 6-0 2-0 4-0
Moneyline Underdog Record 0-0 0-0 0-0


Overall Home Away
Point Total AVG 53.9 54.7 50.0
Implied Total AVG 35.3 35.0 37.0
ATS Record 5-1-0 4-1-0 1-0-0
Over/Under Record 2-4-0 1-4-0 1-0-0
Moneyline Favorite Record 4-0 3-0 1-0
Moneyline Underdog Record 1-0 1-0 0-0

Players to Watch


  • As part of the Tigers’ defensive unit, Barrett Carter has registered 28 tackles, 2.0 TFL, two sacks, and one interception in seven games.
  • Myles Murphy has helped carry the Tigers’ defense with 4.0 sacks to go along with 3.0 TFL and 18 tackles in seven games.
  • K.J. Henry has suited up for seven games, delivering 22 tackles, 3.0 TFL, and one sack for the Tigers.
  • With 32 tackles, Trenton Simpson has helped propel the Tigers’ defense over seven games.


  • Marlowe Wax has posted 19 tackles, 5.0 TFL, and 2.5 sacks in six games for the Orange.
  • In six games for the Orange, Mikel Jones has compiled 17 tackles, 2.0 TFL, and three sacks.
  • Steve Linton has compiled 3.0 sacks to go with 3.0 TFL and nine tackles in six games for the Orange.
  • The Orange’s Garrett Williams has totaled 12 tackles, 1.0 TFL, one sack, and two interceptions in six games.

Clemson vs. Syracuse Predictions and Pick

Clemson vs. Syracuse betting card

    Pick ATS:

    Orange (+14)

    Pick OU:

    Over (49.5)

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How to Bet on Clemson vs. Syracuse

You can bet on Clemson vs. Syracuse at every legal online sportsbook. For more college football odds, including moneylines, spreads, over/under totals as well as college football prop odds, check out the latest college football lines as well as our guide to the best college football betting sites.

And if you wanted to check out how much you could win on a $10 bet if you parlayed today’s Clemson vs. Syracuse picks, don’t forget to check out our free parlay calculator.

Not sure what a parlay is? Or even how to bet on college football? Check out our complete guide to sports betting.

Our pick to win this matchup is Clemson, and we expect that Syracuse will cover the spread (Clemson -14). Finally, we see the scoring in this one going over the posted total of 49.5 points.


Dan Weiner

Hailing from Atlanta and attending college at the University of Texas, Dan is passionate about sports, particularly college football and soccer. He's a diehard Atlanta pro sports and Texas Longhorns fan. He likes every sport and will watch anything and everything the weirder the better. He joined Betsperts after an 11 year career in television production at ESPN.

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