Clemson vs. South Carolina Prediction: Picks & Start Time – November 26, 2022

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The No. 7 Clemson Tigers (10-1) and the South Carolina Gamecocks (7-4) clash in the Palmetto Bowl.

Clemson vs. South Carolina Odds

Point Spread

The spread for this matchup is set at 14.5 points, with bookmakers listing Clemson as the favorites.


As for the moneyline, Clemson has -631 odds to pick up the win, while South Carolina is listed at +448 to claim victory.


Finally, the over/under for the game is set at 53 points.

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Game Info

How to Watch Clemson vs. South Carolina Live?

  • Game Day: Saturday, November 26, 2022
  • Game Time: 12:00 PM ET
  • TV Channel: ABC
  • Location: Berkeley, California
  • Stadium: Memorial Stadium

Betting Preview


On the defensive side of the ball, Clemson has been a top-25 unit, ranking 18th-best by allowing just 319.5 yards per game. The offense ranks 48th (413.4 yards per game). Clemson has been making things happen on both sides of the ball this year, as they rank 25th-best in scoring offense (34.7 points per game) and 23rd-best in scoring defense (20.0 points allowed per game). Offensively, Clemson ranks 68th in the FBS with 228.3 passing yards per game. Meanwhile, the defense ranks 52nd in passing yards allowed per contest (214.3). Clemson sports the 43rd-ranked offense this year in terms of rushing yards (185.1 per game), and has been better defensively, ranking 14th-best with only 105.3 rushing yards allowed per game. On the offensive side of the ball, Clemson has been a top-25 unit in terms of third-down efficiency, ranking 10th-best in the FBS by averaging a 49.7% third-down conversion rate. The defense ranks 40th on defense (35.1% third-down conversion rate allowed). Clemson ranks 100th in college football with a -2 turnover margin after forcing 15 turnovers (78th in the FBS) and committing 17 (74th in the FBS).

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South Carolina

In terms of total offense, South Carolina ranks 77th in the FBS (377.9 total yards per game) and 85th on defense (397.0 total yards allowed per contest). South Carolina is accumulating 31.7 points per game on offense this season (43rd-ranked). Meanwhile, it is surrendering 27.3 points per game (79th-ranked) on defense. From an offensive standpoint, South Carolina is accumulating 248.4 passing yards per game (48th-ranked). It ranks 43rd in the FBS on the other side of the ball (208.6 passing yards allowed per game). South Carolina ranks 96th in rushing yards per game (129.5), but it has been worse on the defensive side of the ball, ranking 23rd-worst in the FBS with 188.4 rushing yards surrendered per contest. With a 40.9% third-down conversion rate on offense, South Carolina ranks 54th in the FBS. On defense, it ranks 97th, allowing a 41.8% third-down rate. After forcing 17 turnovers (47th in the FBS) and turning the ball over 23 times (123rd in the FBS) this season, South Carolina has the 100th-ranked turnover margin of -6.

Clemson vs. South Carolina Betting Analysis

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Clemson Betting Insights

Clemson has put together a 6-5-0 record against the spread this season. In games this season when favored by 14.5 points or more, Clemson are 3-2 against the spread. This season, six Clemson games have gone over the point total. The Tigers have put together a 9-1 record in games they were favored on the moneyline (winning 90% of those games). The Tigers have won all five games they have played as a moneyline favorite with odds of -631 or shorter.

Gamecocks Betting Insights

South Carolina has covered the spread six times this year (6-5-0). In games they have played as 14.5-point underdogs or more, the Gamecocks have an ATS record of 1-1. Games involving South Carolina have hit the over on six occasions this season. The Gamecocks have won three of the six games they’ve played as underdogs this season. This season, the Gamecocks have won two of their three games when they’re the underdog by at least +448 on the moneyline.

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Clemson vs. South Carolina Against The Spread & Betting Records


Overall Home Away
Point Total AVG 51.0 51.3 50.7
Implied Total AVG 34.3 36.5 31.6
ATS Record 6-5-0 3-3-0 3-2-0
Over/Under Record 6-5-0 3-3-0 3-2-0
Moneyline Favorite Record 9-1 5-0 4-1
Moneyline Underdog Record 0-0 0-0 0-0


Overall Home Away
Point Total AVG 54.5 55.9 51.9
Implied Total AVG 34.6 37.6 29.5
ATS Record 6-5-0 4-3-0 2-2-0
Over/Under Record 6-5-0 4-3-0 2-2-0
Moneyline Favorite Record 3-1 2-1 1-0
Moneyline Underdog Record 3-3 2-1 1-2

Players to Watch


  • As part of the Tigers’ defensive unit, Barrett Carter has totaled 44 tackles, 6.0 TFL, four sacks, and two interceptions in 11 games.
  • Jeremiah Trotter Jr. has helped carry the Tigers’ defense with 2.0 sacks to go along with 3.0 TFL, 53 tackles, and one interception in 11 games.
  • With 36 tackles, 5.0 TFL, and three sacks in 11 games, K.J. Henry has been a big contributor to the Tigers’ defense in 2022.
  • The Tigers’ defense has been helped by the play of Trenton Simpson, who has played 11 games, compiling 2.5 sacks to go with 1.0 TFL and 46 tackles.


  • Jordan Burch has compiled 41 tackles, 6.0 TFL, and 3.5 sacks in 11 games for the Gamecocks.
  • Tonka Hemingway has registered 23 tackles, 5.0 TFL, and four sacks in 11 games for the Gamecocks.
  • Sherrod Greene has 1.5 sacks to go with 1.0 TFL, 41 tackles, and one interception in 11 games.
  • The Gamecocks’ DQ Smith has posted 32 tackles, one sack, and one interception in 11 games.

Clemson vs. South Carolina Predictions and Pick

Clemson vs. South Carolina betting card

    Pick ATS:

    Gamecocks (+14.5)

    Pick OU:

    Over (53)

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How to Bet on Clemson vs. South Carolina

You can bet on Clemson vs. South Carolina at every legal online sportsbook. For more college football odds, including moneylines, spreads, over/under totals as well as college football prop odds, check out the latest college football lines as well as our guide to the best college football betting sites.

And if you wanted to check out how much you could win on a $10 bet if you parlayed today’s Clemson vs. South Carolina picks, don’t forget to check out our free parlay calculator.

Not sure what a parlay is? Or even how to bet on college football? Check out our complete guide to sports betting.

Our prediction to win this matchup is Clemson, and we expect that South Carolina will cover the spread (Clemson -14.5). Finally, we see the scoring in this one going over the posted total of 53 points.


Dan Weiner

Hailing from Atlanta and attending college at the University of Texas, Dan is passionate about sports, particularly college football and soccer. He's a diehard Atlanta pro sports and Texas Longhorns fan. He likes every sport and will watch anything and everything the weirder the better. He joined Betsperts after an 11 year career in television production at ESPN.

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