Clemson vs. Florida State Prediction: Picks & Start Time – October 2022

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ACC foes will do battle when the No. 4 Clemson Tigers (6-0) battle the Florida State Seminoles (4-2) at Bobby Bowden Field at Doak Campbell Stadium in Tallahassee, Florida.

Clemson vs. Florida State Odds

Point Spread

The spread for this matchup is set at 4.5 points, with sportsbooks listing Clemson as the favorites.


As for the moneyline, Clemson has -199 odds to pick up the win, while Florida State is listed at +161 to claim victory.


Finally, the over/under for the game is set at 51 points.

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Game Info

How to Watch Clemson vs. Florida State Live?

  • Game Day: Saturday, October 15, 2022
  • Game Time: 7:30 PM ET
  • TV Channel: ABC
  • Location: Tallahassee, Florida
  • Stadium: Bobby Bowden Field at Doak Campbell Stadium

Betting Preview


On defense, Clemson has been a top-25 unit, ranking 23rd-best by allowing only 319.7 yards per game. The offense ranks 55th (426.7 yards per game). Clemson has been firing on all cylinders this season, as they rank 20th-best in scoring offense (39.3 points per game) and 24th-best in scoring defense (18.3 points allowed per game). Clemson is compiling 254.8 passing yards per game on offense, which ranks them 58th in the FBS. The defense ranks 94th, surrendering 255.5 passing yards per contest. Clemson sports the 54th-ranked offense this year in terms of rushing yards (171.8 per game), and has been better on defense, ranking second-best with only 64.2 rushing yards allowed per game. Clemson ranks 45th in third-down defense this year (34.4% third-down conversion rate allowed), but has been playing really well on offense, ranking 13th-best in the FBS with a 50.0% third-down conversion rate. Clemson owns the 24th-best turnover margin in college football at +4, forcing nine turnovers (53rd in the FBS) while turning it over five times (18th in the FBS).

Florida State

Florida State has been a top-25 unit on both offense and defense this season, as it ranks 22nd-best in total yards per game (465.8) and 25th-best in total yards allowed per game (325.7). With 31.3 points per game on the offensive side of the ball, Florida State ranks 59th in the FBS. On defense, it ranks 36th, surrendering 20.8 points per contest. Florida State ranks 47th in the FBS with 261.7 passing yards per game, but it has been lifted up by its defense, which ranks 13th-best by giving up only 170.3 passing yards per contest. Florida State’s run offense has been dominant, posting 204.2 rushing yards per game (25th-best) this season. On defense, it ranks 87th by giving up 155.3 rushing yards per game. From an offensive perspective, Florida State is generating a 46.8% third-down conversion rate (29th-ranked). It ranks 44th in the FBS on defense (34.2% third-down rate allowed). After forcing eight turnovers (72nd in the FBS) and turning the ball over seven times (43rd in the FBS) this season, Florida State has the 53rd-ranked turnover margin of +1.

Clemson vs. Florida State Betting Analysis

Clemson Betting Insights

Clemson has put together a 3-3-0 record against the spread this season. Clemson is 3-3 ATS when playing as at least 4.5-point favorites. Clemson games have finished with a final combined score above the over/under three times this season. The Tigers have not yet lost when playing as the moneyline favorite this season, going 5-0. The Tigers have played in five games as a moneyline favorite with odds of -199 or shorter and won each of them.

Seminoles Betting Insights

Florida State is 3-2-0 against the spread this season. Florida State games have gone over the total twice this year. The Seminoles lost the only game they’ve played as the underdog this season. The Seminoles have played as an underdog of +161 or more once this season and won that game.

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Clemson vs. Florida State Against The Spread & Betting Records


Overall Home Away
Point Total AVG 53.0 53.0 53.0
Implied Total AVG 38.2 41.0 35.3
ATS Record 3-3-0 1-2-0 2-1-0
Over/Under Record 3-3-0 2-1-0 1-2-0
Moneyline Favorite Record 5-0 2-0 3-0
Moneyline Underdog Record 0-0 0-0 0-0


Overall Home Away
Point Total AVG 56.3 58.0 53.8
Implied Total AVG 35.4 40.0 28.5
ATS Record 3-2-0 1-2-0 2-0-0
Over/Under Record 2-3-0 1-2-0 1-1-0
Moneyline Favorite Record 2-1 1-1 1-0
Moneyline Underdog Record 0-1 0-0 0-1

Players to Watch


  • The Tigers’ defense has been aided by Barrett Carter, who has played six games and compiled 24 tackles, 2.0 TFL, two sacks, and one interception.
  • K.J. Henry has hit the gridiron for six games, posting 19 tackles, 3.0 TFL, and one sack for the Tigers.
  • Trenton Simpson has helped spur the Tigers’ defense with 24 tackles in six games.
  • With 2.0 sacks to go along with 3.0 TFL and nine tackles, Tyler Davis has helped propel the Tigers’ defense over six games.


  • Tatum Bethune has been providing a big boost on defense, totaling 38 tackles, 5.0 TFL, one sack, and one pass defended for the Seminoles.
  • Jared Verse has been wreaking havoc on defense, posting 17 tackles, 6.0 TFL, and four sacks for the Seminoles.
  • In six games for the Seminoles, Kalen DeLoach has amassed 23 tackles, 3.0 TFL, and 2.5 sacks.
  • Renardo Green has amassed 2.0 TFL and 33 tackles in six games for the Seminoles.

Clemson vs. Florida State Predictions and Pick

Clemson vs. Florida State betting card

    Pick ATS:

    Tigers (-4.5)

    Pick OU:

    Over (51)

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How to Bet on Clemson vs. Florida State

You can bet on Clemson vs. Florida State at every legal online sportsbook. For more college football odds, including moneylines, spreads, over/under totals as well as college football prop odds, check out the latest college football lines as well as our guide to the best college football betting sites.

And if you wanted to check out how much you could win on a $10 bet if you parlayed today’s Clemson vs. Florida State picks, don’t forget to check out our free parlay calculator.

Not sure what a parlay is? Or even how to bet on college football? Check out our complete guide to sports betting.

Our prediction to win this game is Clemson, and we project that Clemson will cover the spread (Clemson -4.5). Finally, we see the scoring in this one going over the posted total of 51 points.


Dan Weiner

Hailing from Atlanta and attending college at the University of Texas, Dan is passionate about sports, particularly college football and soccer. He's a diehard Atlanta pro sports and Texas Longhorns fan. He likes every sport and will watch anything and everything the weirder the better. He joined Betsperts after an 11 year career in television production at ESPN.

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