Cincinnati vs. Indiana Prediction: Picks & Start Time – September 2022

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It’ll be the Cincinnati Bearcats (2-1) against the Indiana Hoosiers (3-0) in college football play at Nippert Stadium in Cincinnati, Ohio.

Cincinnati vs. Indiana Odds

Point Spread

The spread for this matchup is set at 16.5 points, with bookmakers listing Cincinnati as the favorites.


As for the moneyline, Cincinnati has -776 odds to pick up the win, while Indiana is listed at +514 to claim victory.


Finally, the total for the game is set at 57 points.


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Game Info

How to Watch Cincinnati vs. Indiana Live?

  • Game Day: Saturday, September 24, 2022
  • Game Time: 3:30 PM ET
  • TV Channel: ESPN2
  • Location: Cincinnati, Ohio
  • Stadium: Nippert Stadium

Betting Preview


Offensively, Cincinnati ranks 35th in the FBS with 473.3 yards per game. Meanwhile, its defense ranks 29th in total defense (294.3 yards allowed per contest). Cincinnati ranks 43rd in scoring defense this season (19.3 points allowed per game), but has been shining on the other side of the ball, ranking 23rd-best in the FBS with 41.7 points per game. Cincinnati has been making things happen on both sides of the ball in the passing game this year, ranking 16th-best in passing (318.3 passing yards per game) and 12th-best in passing defense (150.0 passing yards allowed per game). Cincinnati is averaging 155.0 rushing yards per game on offense this year (81st in the FBS), and is allowing 144.3 rushing yards per game (73rd) on defense. Offensively, Cincinnati has been a top-25 unit in terms of third-down efficiency, ranking 17th-best in the FBS by putting up a 52.6% third-down conversion rate. The defense ranks 64th on defense (36.2% third-down percentage allowed). Cincinnati ranks 100th in college football with a -2 turnover margin after forcing 4 turnovers (71st in the FBS) while committing six (95th in the FBS).


Indiana has been struggling on defense, ranking 18th-worst with 441.0 total yards given up per game. It has been better on the other side of the ball, compiling 427.3 total yards per contest (62nd-ranked). With 30.3 points per game on the offensive side of the ball, Indiana ranks 79th in the FBS. On defense, it ranks 64th, allowing 24.0 points per game. Indiana’s pass defense ranks 94th in the FBS with 255.0 passing yards surrendered per contest, but it has been carried by its offense, which ranks 24th-best by posting 297.0 passing yards per contest. Indiana’s defense has been a bottom-25 unit in run defense this season, allowing 186.0 rushing yards per game, which ranks 25th-worst in the FBS. Offensively, it ranks 95th with 130.3 rushing yards per contest. Indiana’s defense has been a bottom-25 unit on third down this season, surrendering a 44.7% third-down conversion rate, which ranks 23rd-worst in the FBS. On the offensive side of the ball, it ranks 40th with a 44.7% third-down rate. Indiana owns a 0 turnover margin this season, which ranks 100th in the FBS.

Cincinnati vs. Indiana Betting Analysis

Cincinnati Betting Insights

Cincinnati has covered the spread one time this season (1-2-0). Cincinnati has an ATS record of 1-1 when playing as at least 16.5-point favorites. Every game involving Cincinnati has hit the over so far this season. The Bearcats have been listed as the moneyline favorite just two other times so far this season, and they won both of the games. The Bearcats have played as a moneyline favorite of -776 or shorter in just two games this season, and they won both.

Hoosiers Betting Insights

Indiana has covered the spread in a game one time this season (1-2-0). This season, Indiana games have hit the over twice. This is the first time the Hoosiers will play as underdogs this season. The Hoosiers have not entered a game this season with longer moneyline odds than +514.


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Cincinnati vs. Indiana Against The Spread & Betting Records


Overall Home Away
Point Total AVG 52.3 51.5 52.8
Implied Total AVG 36.3 40.0 34.5
ATS Record 1-2-0 1-0-0 0-2-0
Over/Under Record 3-0-0 1-0-0 2-0-0
Moneyline Favorite Record 2-0 1-0 1-0
Moneyline Underdog Record 0-1 0-0 0-1


Overall Home Away
Point Total AVG 52.7 52.7
Implied Total AVG 31.7 31.7
ATS Record 1-2-0 1-2-0 0-0-0
Over/Under Record 2-1-0 2-1-0 0-0-0
Moneyline Favorite Record 3-0 3-0 0-0
Moneyline Underdog Record 0-0 0-0 0-0

Players to Watch


  • As part of the Bearcats’ defensive unit, Ivan Pace Jr. has totaled 23 tackles, 5.0 TFL, and two sacks in three games.
  • Jaquan Sheppard has hit the gridiron for three games, collecting nine tackles, 1.0 TFL, and one sack for the Bearcats.
  • Jowon Briggs has helped carry the Bearcats’ defense with 13 tackles, 1.0 TFL, and one sack in three games.
  • With nine tackles, Jabari Taylor has helped lead the Bearcats’ defense over three games.


  • In three games for the Hoosiers, Cam Jones has amassed 1.0 sack to go with 1.0 TFL and 19 tackles.
  • In three games for the Hoosiers, Dasan McCullough has compiled 11 tackles, 3.0 TFL, and three sacks.
  • The Hoosiers’ Noah Pierre has delivered eight tackles and one sack in three games.
  • On defense, Jaylin Williams has piled up 14 tackles in three games.

Cincinnati vs. Indiana Predictions and Pick

Cincinnati vs. Indiana betting card

    Pick ATS:

    Hoosiers (+16.5)

    Pick OU:

    Under (57)


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How to Bet on Cincinnati vs. Indiana

You can bet on Cincinnati vs. Indiana at every legal online sportsbook. For more college football odds, including moneylines, spreads, over/under totals as well as college football prop odds, check out the latest college football lines as well as our guide to the best college football betting sites.

And if you wanted to check out how much you could win on a $10 bet if you parlayed today’s Cincinnati vs. Indiana picks, don’t forget to check out our free parlay calculator.

Not sure what a parlay is? Or even how to bet on college football? Check out our complete guide to sports betting.

Our prediction to win this contest is Indiana, and we predict that Indiana will cover the spread (Cincinnati -16.5). Finally, we see the scoring in this one going under the posted total of 57 points.


Dan Weiner

Hailing from Atlanta and attending college at the University of Texas, Dan is passionate about sports, particularly college football and soccer. He's a diehard Atlanta pro sports and Texas Longhorns fan. He likes every sport and will watch anything and everything the weirder the better. He joined Betsperts after an 11 year career in television production at ESPN.

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